CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : CodonNum = 35 & Codon = aTa

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp4	35	K35I	K2798I	nonsyn	aAa	aTa	348	181	0.520115	8657-8659

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp4	35	K35I	aAa	aTa	181	348	All	0.000035
ORF1ab/nsp4	35	K35I	aAa	aTa	157	310	B.1.1.7	0.000141
ORF1ab/nsp4	35	K35I	aAa	aTa	6	12	P.1	0.000095
ORF1ab/nsp4	35	K35I	aAa	aTa	3	5	B.1	0.000027
ORF1ab/nsp4	35	K35I	aAa	aTa	2	4	B.1.1	0.000036
ORF1ab/nsp4	35	K35I	aAa	aTa	3	4	B.1.617.2	0.000011
ORF1ab/nsp4	35	K35I	aAa	aTa	1	2	AY.110	0.000113
ORF1ab/nsp4	35	K35I	aAa	aTa	1	2	AY.25	0.000006
ORF1ab/nsp4	35	K35I	aAa	aTa	2	2	AY.4	0.000003
ORF1ab/nsp4	35	K35I	aAa	aTa	1	2	B.1.576	0.000907
ORF1ab/nsp4	35	K35I	aAa	aTa	1	1	AY.103	0.000006
ORF1ab/nsp4	35	K35I	aAa	aTa	1	1	B.1.1.39	0.00051
ORF1ab/nsp4	35	K35I	aAa	aTa	1	1	B.1.234	0.000132
ORF1ab/nsp4	35	K35I	aAa	aTa	1	1	B.1.595	0.000261
ORF1ab/nsp4	35	K35I	aAa	aTa	1	1	D.2	0.000075

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.