CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : CodonNum = 35 & Codon = aTT

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp4	35	K35I	K2798I	nonsyn	aAA	aTT	348	162	0.465517	8657-8659

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp4	35	K35I	aAA	aTT	162	348	All	0.000031
ORF1ab/nsp4	35	K35I	aAA	aTT	148	310	B.1.1.7	0.000132
ORF1ab/nsp4	35	K35I	aAA	aTT	6	12	P.1	0.000095
ORF1ab/nsp4	35	K35I	aAA	aTT	2	5	B.1	0.000018
ORF1ab/nsp4	35	K35I	aAA	aTT	2	4	B.1.1	0.000036
ORF1ab/nsp4	35	K35I	aAA	aTT	1	4	B.1.617.2	0.000004
ORF1ab/nsp4	35	K35I	aAA	aTT	1	2	AY.110	0.000113
ORF1ab/nsp4	35	K35I	aAA	aTT	1	2	AY.25	0.000006
ORF1ab/nsp4	35	K35I	aAA	aTT	1	2	B.1.576	0.000907

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.