CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp4 : CodonNum = 189

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp4189T189IT2952InonsynaCaaTa6503650319119-9121
ORF1ab/nsp4189T189TT2952TsynacAacG1971710.868029119-9121
ORF1ab/nsp4189T189TT2952TsynacAacC197230.1167519119-9121
ORF1ab/nsp4189T189TT2952TsynacAacT19730.01522849119-9121
ORF1ab/nsp4189T189delT2952deldelACA---636319119-9121
ORF1ab/nsp4189T189AT2952AnonsynAcaGca515119119-9121
ORF1ab/nsp4189T189KT2952KnonsynaCaaAa9919119-9121
ORF1ab/nsp4189T189XT2952XnonsynACaTAa530.69119-9121
ORF1ab/nsp4189T189XT2952XnonsynACaTGa520.49119-9121
ORF1ab/nsp4189T189LT2952LnonsynACaTTa4419119-9121
ORF1ab/nsp4189T189ST2952SnonsynAcaTca3319119-9121
ORF1ab/nsp4189T189RT2952RnonsynaCaaGa1119119-9121
ORF1ab/nsp4189T189NT2952NnonsynaCAaAC1119119-9121
ORF1ab/nsp4189T189del2T2952del2delaCAa--1119119-9121

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp4189T189IaCaaTa65036503All0.001244
ORF1ab/nsp4189T189IaCaaTa19581958B.1.621.10.990389
ORF1ab/nsp4189T189IaCaaTa17091709B.1.6230.916845
ORF1ab/nsp4189T189IaCaaTa479479B.1.1.3020.993776
ORF1ab/nsp4189T189IaCaaTa459459B.1.5740.987097
ORF1ab/nsp4189T189IaCaaTa214214B.1.1.1591
ORF1ab/nsp4189T189TacAacG171197All0.000033
ORF1ab/nsp4189T189TacAacC23197All0.000004
ORF1ab/nsp4189T189TacAacT3197All0.000001
ORF1ab/nsp4189T189IaCaaTa152152B.1.1.70.000136
ORF1ab/nsp4189T189IaCaaTa145145B.1.1770.001909
ORF1ab/nsp4189T189IaCaaTa141141B.1.1.5190.005599
ORF1ab/nsp4189T189IaCaaTa138138AY.40.000215
ORF1ab/nsp4189T189IaCaaTa120120B.1.5960.010457
ORF1ab/nsp4189T189IaCaaTa115115B.10.001053
ORF1ab/nsp4189T189IaCaaTa8686B.1.6210.007613
ORF1ab/nsp4189T189IaCaaTa8383B.1.110.30.059626
ORF1ab/nsp4189T189IaCaaTa6868AY.30.000676
ORF1ab/nsp4189T189delACA---6363All0.000012
ORF1ab/nsp4189T189AAcaGca5151All0.00001
ORF1ab/nsp4189T189IaCaaTa4242AY.1030.000261
ORF1ab/nsp4189T189IaCaaTa4242B.1.617.20.000158
ORF1ab/nsp4189T189IaCaaTa4141AY.250.000247
ORF1ab/nsp4189T189IaCaaTa3636P.10.000567
ORF1ab/nsp4189T189IaCaaTa3434AY.430.000151
ORF1ab/nsp4189T189IaCaaTa3030AY.710.014252
ORF1ab/nsp4189T189TacAacG2329B.1.1.70.000021
ORF1ab/nsp4189T189TacAacC529B.1.1.70.000004
ORF1ab/nsp4189T189TacAacT129B.1.1.70.000001
ORF1ab/nsp4189T189IaCaaTa2929B.1.20.000255
ORF1ab/nsp4189T189TacAacG2828AY.440.00017
ORF1ab/nsp4189T189IaCaaTa2525AY.440.000152
ORF1ab/nsp4189T189TacAacG2525B.1.617.20.000094
ORF1ab/nsp4189T189delACA---2121B.1.1.70.000019
ORF1ab/nsp4189T189IaCaaTa1919B.1.2940.612903
ORF1ab/nsp4189T189TacAacG1818AY.40.000028
ORF1ab/nsp4189T189IaCaaTa1818B.1.10.000327
ORF1ab/nsp4189T189IaCaaTa1818B.1.1.2220.003672
ORF1ab/nsp4189T189IaCaaTa1616B.1.3240.025682
ORF1ab/nsp4189T189IaCaaTa1515B.1.4040.019531
ORF1ab/nsp4189T189TacAacC1414AY.420.000563
ORF1ab/nsp4189T189IaCaaTa1313B.1.360.001897
ORF1ab/nsp4189T189IaCaaTa1313B.1.5260.000306
ORF1ab/nsp4189T189AAcaGca1212B.10.00011
ORF1ab/nsp4189T189IaCaaTa1212B.1.1.4060.077922
ORF1ab/nsp4189T189KaCaaAa99All0.000002
ORF1ab/nsp4189T189IaCaaTa99B.1.1600.000281
ORF1ab/nsp4189T189TacAacG88AY.1020.000212
ORF1ab/nsp4189T189IaCaaTa88AY.1020.000212
ORF1ab/nsp4189T189IaCaaTa88AY.4.20.000174
ORF1ab/nsp4189T189AAcaGca88B.1.1.70.000007
ORF1ab/nsp4189T189TacAacG88B.1.2650.010165
ORF1ab/nsp4189T189TacAacG88R.10.00072
ORF1ab/nsp4189T189delACA---77AY.4.50.000752
ORF1ab/nsp4189T189IaCaaTa77B.1.2210.000497
ORF1ab/nsp4189T189IaCaaTa77B.1.3510.000208
ORF1ab/nsp4189T189TacAacG66AY.1030.000037
ORF1ab/nsp4189T189TacAacG66AY.250.000036
ORF1ab/nsp4189T189IaCaaTa66AY.260.00017
ORF1ab/nsp4189T189delACA---66AY.430.000027
ORF1ab/nsp4189T189IaCaaTa66AY.470.000187
ORF1ab/nsp4189T189XACaTAa35All0.000001
ORF1ab/nsp4189T189XACaTGa25All0
ORF1ab/nsp4189T189AAcaGca55AY.1100.000563
ORF1ab/nsp4189T189IaCaaTa55AY.1170.000423
ORF1ab/nsp4189T189IaCaaTa55B.1.1.280.001556
ORF1ab/nsp4189T189delACA---55B.1.1770.000066
ORF1ab/nsp4189T189IaCaaTa55B.1.3670.003962
ORF1ab/nsp4189T189IaCaaTa55B.1.4270.000252
ORF1ab/nsp4189T189IaCaaTa55B.1.5250.000566
ORF1ab/nsp4189T189IaCaaTa55B.1.617.10.000645
ORF1ab/nsp4189T189IaCaaTa55B.1.6370.000365
ORF1ab/nsp4189T189IaCaaTa55D.20.000375
ORF1ab/nsp4189T189LACaTTa440.222222
ORF1ab/nsp4189T189XACaTAa240.111111
ORF1ab/nsp4189T189XACaTGa240.111111
ORF1ab/nsp4189T189LACaTTa44All0.000001
ORF1ab/nsp4189T189AAcaGca44AY.1030.000025
ORF1ab/nsp4189T189AAcaGca44AY.40.000006
ORF1ab/nsp4189T189IaCaaTa44AY.46.30.003735
ORF1ab/nsp4189T189IaCaaTa44AY.530.00115
ORF1ab/nsp4189T189TacAacG44B.1.4290.000094
ORF1ab/nsp4189T189IaCaaTa44B.1.4700.005618
ORF1ab/nsp4189T189SAcaTca33All0.000001
ORF1ab/nsp4189T189IaCaaTa33AY.1190.000106
ORF1ab/nsp4189T189IaCaaTa33AY.230.000209
ORF1ab/nsp4189T189TacAacG33AY.290.000047
ORF1ab/nsp4189T189TacAacG33AY.350.000699
ORF1ab/nsp4189T189IaCaaTa33AY.390.000074
ORF1ab/nsp4189T189AAcaGca33AY.4.2.10.000447
ORF1ab/nsp4189T189IaCaaTa33AY.610.000314
ORF1ab/nsp4189T189IaCaaTa33AY.730.001996
ORF1ab/nsp4189T189TacAacG33B.1.10.000054
ORF1ab/nsp4189T189IaCaaTa33B.1.1.3120.005736
ORF1ab/nsp4189T189TacAacG33B.1.1.4320.003797
ORF1ab/nsp4189T189IaCaaTa33B.1.1.4340.001046
ORF1ab/nsp4189T189TacAacG33B.1.1.5190.000119
ORF1ab/nsp4189T189IaCaaTa33B.1.2320.001612
ORF1ab/nsp4189T189AAcaGca33B.1.2320.001612
ORF1ab/nsp4189T189AAcaGca33B.1.3510.000089
ORF1ab/nsp4189T189IaCaaTa33B.1.3610.003866
ORF1ab/nsp4189T189IaCaaTa33B.1.466.20.001174
ORF1ab/nsp4189T189IaCaaTa33P.20.00056
ORF1ab/nsp4189T189SAcaTca220.111111
ORF1ab/nsp4189T189IaCaaTa22AY.140.000176
ORF1ab/nsp4189T189IaCaaTa22AY.16.10.00094
ORF1ab/nsp4189T189IaCaaTa22AY.290.000032
ORF1ab/nsp4189T189IaCaaTa22AY.46.40.000329
ORF1ab/nsp4189T189IaCaaTa22AY.46.60.000144
ORF1ab/nsp4189T189TacAacG22AY.50.000041
ORF1ab/nsp4189T189IaCaaTa22AY.75.10.000361
ORF1ab/nsp4189T189IaCaaTa22AY.90.000135
ORF1ab/nsp4189T189TacAacT12AY.99.20.000092
ORF1ab/nsp4189T189TacAacG12AY.99.20.000092
ORF1ab/nsp4189T189IaCaaTa22B.1.1.2200.003717
ORF1ab/nsp4189T189IaCaaTa22B.1.1.2410.004141
ORF1ab/nsp4189T189IaCaaTa22B.1.1.3260.003521
ORF1ab/nsp4189T189IaCaaTa22B.1.1.4850.033333
ORF1ab/nsp4189T189TacAacG12B.1.1600.000031
ORF1ab/nsp4189T189TacAacC12B.1.1600.000031
ORF1ab/nsp4189T189delACA---22B.1.177.180.00232
ORF1ab/nsp4189T189delACA---22B.1.177.40.000422
ORF1ab/nsp4189T189IaCaaTa22B.1.2430.000139
ORF1ab/nsp4189T189IaCaaTa22B.1.2580.000133
ORF1ab/nsp4189T189IaCaaTa22B.1.36.170.000988
ORF1ab/nsp4189T189IaCaaTa22B.1.36.240.012346
ORF1ab/nsp4189T189IaCaaTa22B.1.4290.000047
ORF1ab/nsp4189T189IaCaaTa22B.1.6090.000959
ORF1ab/nsp4189T189KaCaaAa22B.1.617.20.000008
ORF1ab/nsp4189T189AAcaGca22B.1.617.20.000008
ORF1ab/nsp4189T189IaCaaTa22P.1.120.000968
ORF1ab/nsp4189T189TacAacC110.055556
ORF1ab/nsp4189T189NaCAaAC110.055556
ORF1ab/nsp4189T189KaCaaAa110.055556
ORF1ab/nsp4189T189KaCaaAa11A.20.000662
ORF1ab/nsp4189T189IaCaaTa11A.23.10.000704
ORF1ab/nsp4189T189del2aCAa--11All0
ORF1ab/nsp4189T189RaCaaGa11All0
ORF1ab/nsp4189T189NaCAaAC11All0
ORF1ab/nsp4189T189IaCaaTa11AY.1050.000643
ORF1ab/nsp4189T189AAcaGca11AY.1130.000142
ORF1ab/nsp4189T189IaCaaTa11AY.1180.000063
ORF1ab/nsp4189T189TacAacG11AY.1190.000035
ORF1ab/nsp4189T189IaCaaTa11AY.120.000316
ORF1ab/nsp4189T189delACA---11AY.1200.000037
ORF1ab/nsp4189T189IaCaaTa11AY.1200.000037
ORF1ab/nsp4189T189IaCaaTa11AY.160.00038
ORF1ab/nsp4189T189TacAacG11AY.190.00114
ORF1ab/nsp4189T189IaCaaTa11AY.200.000039
ORF1ab/nsp4189T189TacAacG11AY.30.00001
ORF1ab/nsp4189T189delACA---11AY.30.00001
ORF1ab/nsp4189T189IaCaaTa11AY.320.000532
ORF1ab/nsp4189T189delACA---11AY.330.000067
ORF1ab/nsp4189T189IaCaaTa11AY.330.000067
ORF1ab/nsp4189T189TacAacG11AY.390.000025
ORF1ab/nsp4189T189KaCaaAa11AY.40.000002
ORF1ab/nsp4189T189delACA---11AY.40.000002
ORF1ab/nsp4189T189TacAacG11AY.4.20.000022
ORF1ab/nsp4189T189IaCaaTa11AY.4.50.000107
ORF1ab/nsp4189T189IaCaaTa11AY.420.00004
ORF1ab/nsp4189T189KaCaaAa11AY.430.000004
ORF1ab/nsp4189T189TacAacG11AY.430.000004
ORF1ab/nsp4189T189del2aCAa--11AY.440.000006
ORF1ab/nsp4189T189AAcaGca11AY.440.000006
ORF1ab/nsp4189T189IaCaaTa11AY.450.000122
ORF1ab/nsp4189T189TacAacG11AY.470.000031
ORF1ab/nsp4189T189IaCaaTa11AY.50.000021
ORF1ab/nsp4189T189IaCaaTa11AY.520.000814
ORF1ab/nsp4189T189IaCaaTa11AY.540.000095
ORF1ab/nsp4189T189AAcaGca11AY.60.000041
ORF1ab/nsp4189T189AAcaGca11AY.610.000105
ORF1ab/nsp4189T189IaCaaTa11AY.660.00107
ORF1ab/nsp4189T189TacAacG11AY.690.000187
ORF1ab/nsp4189T189TacAacG11AY.7.10.000113
ORF1ab/nsp4189T189TacAacG11AY.710.000475
ORF1ab/nsp4189T189IaCaaTa11AY.750.000056
ORF1ab/nsp4189T189IaCaaTa11AY.770.001127
ORF1ab/nsp4189T189IaCaaTa11AY.790.001211
ORF1ab/nsp4189T189IaCaaTa11AY.830.001724
ORF1ab/nsp4189T189IaCaaTa11AY.870.000833
ORF1ab/nsp4189T189IaCaaTa11AY.880.000884
ORF1ab/nsp4189T189delACA---11AY.90.000068
ORF1ab/nsp4189T189IaCaaTa11AY.9.10.000084
ORF1ab/nsp4189T189IaCaaTa11AY.9.20.000037
ORF1ab/nsp4189T189delACA---11AY.950.000761
ORF1ab/nsp4189T189IaCaaTa11AY.980.000079
ORF1ab/nsp4189T189IaCaaTa11AY.98.10.000048
ORF1ab/nsp4189T189delACA---11B.10.000009
ORF1ab/nsp4189T189XACaTAa11B.1.10.000018
ORF1ab/nsp4189T189KaCaaAa11B.1.10.000018
ORF1ab/nsp4189T189delACA---11B.1.10.000018
ORF1ab/nsp4189T189IaCaaTa11B.1.1.10.000327
ORF1ab/nsp4189T189IaCaaTa11B.1.1.1280.007092
ORF1ab/nsp4189T189TacAacG11B.1.1.1570.000913
ORF1ab/nsp4189T189IaCaaTa11B.1.1.1890.001513
ORF1ab/nsp4189T189IaCaaTa11B.1.1.2140.000055
ORF1ab/nsp4189T189IaCaaTa11B.1.1.250.000569
ORF1ab/nsp4189T189IaCaaTa11B.1.1.2530.002506
ORF1ab/nsp4189T189IaCaaTa11B.1.1.3060.000438
ORF1ab/nsp4189T189delACA---11B.1.1.3060.000438
ORF1ab/nsp4189T189delACA---11B.1.1.390.00051
ORF1ab/nsp4189T189delACA---11B.1.1.4090.002833
ORF1ab/nsp4189T189AAcaGca11B.1.1.5260.003546
ORF1ab/nsp4189T189IaCaaTa11B.1.1.630.000386
ORF1ab/nsp4189T189IaCaaTa11B.1.1110.001175
ORF1ab/nsp4189T189KaCaaAa11B.1.1600.000031
ORF1ab/nsp4189T189IaCaaTa11B.1.177.210.000076
ORF1ab/nsp4189T189TacAacG11B.1.177.210.000076
ORF1ab/nsp4189T189delACA---11B.1.177.630.002703
ORF1ab/nsp4189T189IaCaaTa11B.1.177.730.000566
ORF1ab/nsp4189T189IaCaaTa11B.1.177.810.000189
ORF1ab/nsp4189T189delACA---11B.1.20.000009
ORF1ab/nsp4189T189TacAacC11B.1.20.000009
ORF1ab/nsp4189T189IaCaaTa11B.1.2340.000132
ORF1ab/nsp4189T189AAcaGca11B.1.2340.000132
ORF1ab/nsp4189T189IaCaaTa11B.1.2370.004975
ORF1ab/nsp4189T189IaCaaTa11B.1.2400.000216
ORF1ab/nsp4189T189delACA---11B.1.2420.018868
ORF1ab/nsp4189T189TacAacG11B.1.2430.00007
ORF1ab/nsp4189T189IaCaaTa11B.1.30.002618
ORF1ab/nsp4189T189TacAacG11B.1.3510.00003
ORF1ab/nsp4189T189IaCaaTa11B.1.351.50.0006
ORF1ab/nsp4189T189delACA---11B.1.36.170.000494
ORF1ab/nsp4189T189delACA---11B.1.36.180.00042
ORF1ab/nsp4189T189IaCaaTa11B.1.36.220.001208
ORF1ab/nsp4189T189IaCaaTa11B.1.36.290.000517
ORF1ab/nsp4189T189IaCaaTa11B.1.36.380.001642
ORF1ab/nsp4189T189IaCaaTa11B.1.3660.004878
ORF1ab/nsp4189T189delACA---11B.1.3670.000792
ORF1ab/nsp4189T189IaCaaTa11B.1.3690.000285
ORF1ab/nsp4189T189IaCaaTa11B.1.3750.00082
ORF1ab/nsp4189T189IaCaaTa11B.1.3890.001002
ORF1ab/nsp4189T189IaCaaTa11B.1.3950.007042
ORF1ab/nsp4189T189IaCaaTa11B.1.3990.001934
ORF1ab/nsp4189T189delACA---11B.1.4150.014286
ORF1ab/nsp4189T189TacAacG11B.1.466.20.000391
ORF1ab/nsp4189T189IaCaaTa11B.1.4850.014925
ORF1ab/nsp4189T189IaCaaTa11B.1.5060.02381
ORF1ab/nsp4189T189SAcaTca11B.1.5640.000426
ORF1ab/nsp4189T189IaCaaTa11B.1.5760.000907
ORF1ab/nsp4189T189IaCaaTa11B.1.5790.011236
ORF1ab/nsp4189T189TacAacG11B.1.5900.004545
ORF1ab/nsp4189T189TacAacC11B.1.5960.000087
ORF1ab/nsp4189T189AAcaGca11B.1.5960.000087
ORF1ab/nsp4189T189TacAacG11B.1.6050.005952
ORF1ab/nsp4189T189delACA---11B.1.617.20.000004
ORF1ab/nsp4189T189KaCaaAa11B.1.6230.000536
ORF1ab/nsp4189T189IaCaaTa11B.1.810.021277
ORF1ab/nsp4189T189delACA---11B.150.017544
ORF1ab/nsp4189T189IaCaaTa11B.4.20.066667
ORF1ab/nsp4189T189RaCaaGa11C.350.000774
ORF1ab/nsp4189T189IaCaaTa11C.370.000116
ORF1ab/nsp4189T189TacAacT11C.370.000116
ORF1ab/nsp4189T189TacAacG11P.10.000016
ORF1ab/nsp4189T189IaCaaTa11P.1.140.000048
ORF1ab/nsp4189T189IaCaaTa11P.1.150.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.