CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = Y978Y
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 978 | Y978Y | Y1796Y | syn | taT | taC | 5472 | 5472 | 1 | 5651-5653 |
Details of the mutation Y978Y within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 5472 | 5472 | All | 0.001047 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2644 | 2644 | AY.4 | 0.004115 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1309 | 1309 | B.1.36.27 | 0.999237 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 637 | 637 | B.1.36 | 0.092938 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 246 | 246 | B.1.1.7 | 0.00022 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 154 | 154 | AY.43 | 0.000682 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 66 | 66 | AY.103 | 0.00041 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 64 | 64 | B.1 | 0.000586 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 43 | 43 | B.1.617.2 | 0.000162 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 36 | 36 | B.1.36.22 | 0.043478 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 31 | 31 | AY.9.1 | 0.002595 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 18 | 18 | B.1.1 | 0.000327 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 11 | 11 | C.37 | 0.001277 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 9 | 9 | B.1.260 | 0.0301 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 8 | 8 | B.1.1.526 | 0.028369 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 8 | 8 | B.1.177.60 | 0.001747 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 7 | 7 | AY.25 | 0.000042 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 7 | 7 | AY.39 | 0.000173 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 7 | 7 | AY.61 | 0.000733 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 7 | 7 | B.1.221 | 0.000497 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 7 | 7 | B.1.36.38 | 0.011494 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 6 | 6 | AY.26 | 0.00017 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 6 | 6 | AY.42 | 0.000241 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 6 | 6 | AY.44 | 0.000037 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 6 | 6 | B.1.2 | 0.000053 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 6 | 6 | B.1.468 | 0.034286 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 5 | 5 | AY.29 | 0.000079 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 5 | 5 | B.1.177.53 | 0.011962 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 5 | 5 | B.1.456 | 0.01634 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 5 | 5 | P.1 | 0.000079 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | AY.118 | 0.000251 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | AY.4.3 | 0.003367 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | AY.5 | 0.000083 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | B.1.160 | 0.000125 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 4 | 4 | B.1.36.16 | 0.005698 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 3 | 3 | B.1.36.17 | 0.001482 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 3 | 3 | B.1.462 | 0.021739 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 3 | 3 | B.1.533 | 0.028846 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 3 | 3 | P.1.15 | 0.000697 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.14 | 0.000176 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.28 | 0.003781 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.4.2.1 | 0.000298 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.74 | 0.000231 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.84 | 0.000875 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | B.1.1.273 | 0.013514 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | B.39 | 0.004662 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 2 | 2 | C.1 | 0.004785 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AU.2 | 0.002421 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.10 | 0.00053 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.38 | 0.000499 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.4.2 | 0.000022 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.46.1 | 0.001027 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.47 | 0.000031 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.1.139 | 0.022727 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.1.291 | 0.000742 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.111 | 0.001175 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.147 | 0.000756 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.164 | 0.014925 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.177.31 | 0.011494 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.337 | 0.005587 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.33 | 0.007576 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.34 | 0.021277 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.7 | 0.004 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.36.8 | 0.001 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.408 | 0.00369 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.517 | 0.000427 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.523 | 0.002451 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | B.1.623 | 0.000536 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | L.3 | 0.003546 |
| ORF1ab/nsp3 | 978 | Y978Y | taT | taC | 1 | 1 | P.3 | 0.001595 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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