CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = V253V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3253V253VV1071VsyngtTgtA162810240.6289933476-3478
ORF1ab/nsp3253V253VV1071VsyngtTgtC16284490.2757993476-3478
ORF1ab/nsp3253V253VV1071VsyngtTgtG16281550.09520883476-3478

Details of the mutation V253V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3253V253VgtTgtA10241628All0.000196
ORF1ab/nsp3253V253VgtTgtC4491628All0.000086
ORF1ab/nsp3253V253VgtTgtG1551628All0.00003
ORF1ab/nsp3253V253VgtTgtA777826AY.40.001209
ORF1ab/nsp3253V253VgtTgtC49826AY.40.000076
ORF1ab/nsp3253V253VgtTgtG131131B.1.1.5250.715847
ORF1ab/nsp3253V253VgtTgtC9494AY.460.009784
ORF1ab/nsp3253V253VgtTgtC5782B.1.1.70.000051
ORF1ab/nsp3253V253VgtTgtA2482B.1.1.70.000021
ORF1ab/nsp3253V253VgtTgtG182B.1.1.70.000001
ORF1ab/nsp3253V253VgtTgtA2649B.1.617.20.000098
ORF1ab/nsp3253V253VgtTgtC2349B.1.617.20.000087
ORF1ab/nsp3253V253VgtTgtA3236AY.30.000318
ORF1ab/nsp3253V253VgtTgtC436AY.30.00004
ORF1ab/nsp3253V253VgtTgtA3434B.1.1.2840.003652
ORF1ab/nsp3253V253VgtTgtA2626B.1.160.80.033505
ORF1ab/nsp3253V253VgtTgtC2424AY.330.001603
ORF1ab/nsp3253V253VgtTgtA2424B.1.1.5190.000953
ORF1ab/nsp3253V253VgtTgtC1522B.1.10.000272
ORF1ab/nsp3253V253VgtTgtG422B.1.10.000073
ORF1ab/nsp3253V253VgtTgtA322B.1.10.000054
ORF1ab/nsp3253V253VgtTgtC1321AY.50.000268
ORF1ab/nsp3253V253VgtTgtG821AY.50.000165
ORF1ab/nsp3253V253VgtTgtC1920AY.250.000114
ORF1ab/nsp3253V253VgtTgtA120AY.250.000006
ORF1ab/nsp3253V253VgtTgtC1116AY.430.000049
ORF1ab/nsp3253V253VgtTgtA516AY.430.000022
ORF1ab/nsp3253V253VgtTgtC915B.1.5960.000784
ORF1ab/nsp3253V253VgtTgtA615B.1.5960.000523
ORF1ab/nsp3253V253VgtTgtC814B.10.000073
ORF1ab/nsp3253V253VgtTgtA414B.10.000037
ORF1ab/nsp3253V253VgtTgtG214B.10.000018
ORF1ab/nsp3253V253VgtTgtC1112AY.440.000067
ORF1ab/nsp3253V253VgtTgtA112AY.440.000006
ORF1ab/nsp3253V253VgtTgtA612B.1.20.000053
ORF1ab/nsp3253V253VgtTgtC412B.1.20.000035
ORF1ab/nsp3253V253VgtTgtG212B.1.20.000018
ORF1ab/nsp3253V253VgtTgtC1010AY.4.20.000217
ORF1ab/nsp3253V253VgtTgtC99AY.1180.000564
ORF1ab/nsp3253V253VgtTgtA99B.1.2980.019027
ORF1ab/nsp3253V253VgtTgtC88AY.1210.001083
ORF1ab/nsp3253V253VgtTgtA88B.1.1110.009401
ORF1ab/nsp3253V253VgtTgtC77D.20.000525
ORF1ab/nsp3253V253VgtTgtC66A.2.50.002994
ORF1ab/nsp3253V253VgtTgtC55AY.740.000578
ORF1ab/nsp3253V253VgtTgtC45B.1.1.3060.001754
ORF1ab/nsp3253V253VgtTgtA15B.1.1.3060.000438
ORF1ab/nsp3253V253VgtTgtC55B.1.258.170.00052
ORF1ab/nsp3253V253VgtTgtC34AY.1030.000019
ORF1ab/nsp3253V253VgtTgtA14AY.1030.000006
ORF1ab/nsp3253V253VgtTgtA24AY.450.000243
ORF1ab/nsp3253V253VgtTgtC24AY.450.000243
ORF1ab/nsp3253V253VgtTgtC23AY.390.000049
ORF1ab/nsp3253V253VgtTgtA13AY.390.000025
ORF1ab/nsp3253V253VgtTgtC33AY.46.60.000217
ORF1ab/nsp3253V253VgtTgtA33B.1.1.2310.009288
ORF1ab/nsp3253V253VgtTgtC23B.1.1770.000026
ORF1ab/nsp3253V253VgtTgtA13B.1.1770.000013
ORF1ab/nsp3253V253VgtTgtG23B.1.2340.000264
ORF1ab/nsp3253V253VgtTgtC13B.1.2340.000132
ORF1ab/nsp3253V253VgtTgtA33B.1.4290.000071
ORF1ab/nsp3253V253VgtTgtC120.055556
ORF1ab/nsp3253V253VgtTgtA120.055556
ORF1ab/nsp3253V253VgtTgtC22AY.240.000862
ORF1ab/nsp3253V253VgtTgtC22AY.260.000057
ORF1ab/nsp3253V253VgtTgtC22AY.290.000032
ORF1ab/nsp3253V253VgtTgtC22AY.3.10.000171
ORF1ab/nsp3253V253VgtTgtG22AY.470.000062
ORF1ab/nsp3253V253VgtTgtC22AY.570.001312
ORF1ab/nsp3253V253VgtTgtA22AY.680.000547
ORF1ab/nsp3253V253VgtTgtA22AY.980.000158
ORF1ab/nsp3253V253VgtTgtC22B.1.1.1410.004024
ORF1ab/nsp3253V253VgtTgtC22B.1.1.630.000772
ORF1ab/nsp3253V253VgtTgtA22B.1.177.860.000367
ORF1ab/nsp3253V253VgtTgtC22B.1.2430.000139
ORF1ab/nsp3253V253VgtTgtC22B.1.2580.000133
ORF1ab/nsp3253V253VgtTgtA22B.1.5260.000047
ORF1ab/nsp3253V253VgtTgtA22P.1.140.000096
ORF1ab/nsp3253V253VgtTgtA22P.20.000373
ORF1ab/nsp3253V253VgtTgtA11A0.000387
ORF1ab/nsp3253V253VgtTgtC11AY.1000.000046
ORF1ab/nsp3253V253VgtTgtC11AY.1020.000027
ORF1ab/nsp3253V253VgtTgtG11AY.130.000161
ORF1ab/nsp3253V253VgtTgtA11AY.320.000532
ORF1ab/nsp3253V253VgtTgtA11AY.340.000097
ORF1ab/nsp3253V253VgtTgtC11AY.380.000499
ORF1ab/nsp3253V253VgtTgtA11AY.39.10.00004
ORF1ab/nsp3253V253VgtTgtC11AY.46.40.000165
ORF1ab/nsp3253V253VgtTgtC11AY.520.000814
ORF1ab/nsp3253V253VgtTgtA11AY.60.000041
ORF1ab/nsp3253V253VgtTgtA11AY.610.000105
ORF1ab/nsp3253V253VgtTgtC11AY.620.000436
ORF1ab/nsp3253V253VgtTgtC11AY.710.000475
ORF1ab/nsp3253V253VgtTgtA11AY.840.000437
ORF1ab/nsp3253V253VgtTgtG11AY.9.20.000037
ORF1ab/nsp3253V253VgtTgtC11B.1.1.3070.002532
ORF1ab/nsp3253V253VgtTgtA11B.1.1.370.000193
ORF1ab/nsp3253V253VgtTgtC11B.1.1.3890.006061
ORF1ab/nsp3253V253VgtTgtC11B.1.1.3980.003226
ORF1ab/nsp3253V253VgtTgtC11B.1.1.4170.002703
ORF1ab/nsp3253V253VgtTgtG11B.1.1.50.008333
ORF1ab/nsp3253V253VgtTgtC11B.1.130.002375
ORF1ab/nsp3253V253VgtTgtA11B.1.177.600.000218
ORF1ab/nsp3253V253VgtTgtA11B.1.2210.000071
ORF1ab/nsp3253V253VgtTgtC11B.1.3300.028571
ORF1ab/nsp3253V253VgtTgtC11B.1.3380.008621
ORF1ab/nsp3253V253VgtTgtA11B.1.3910.001127
ORF1ab/nsp3253V253VgtTgtC11B.1.4030.003268
ORF1ab/nsp3253V253VgtTgtA11B.1.4700.001404
ORF1ab/nsp3253V253VgtTgtC11B.1.4990.00105
ORF1ab/nsp3253V253VgtTgtC11B.1.5080.025641
ORF1ab/nsp3253V253VgtTgtC11B.1.5610.000397
ORF1ab/nsp3253V253VgtTgtC11B.1.617.10.000129
ORF1ab/nsp3253V253VgtTgtC11B.1.6370.000073
ORF1ab/nsp3253V253VgtTgtC11B.310.003731
ORF1ab/nsp3253V253VgtTgtC11C.36.3.10.002717
ORF1ab/nsp3253V253VgtTgtA11C.370.000116

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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