CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = V1897I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 1897 | V1897I | V2715I | nonsyn | Gtt | Att | 659 | 653 | 0.990895 | 8408-8410 |
| ORF1ab/nsp3 | 1897 | V1897I | V2715I | nonsyn | GtT | AtA | 659 | 5 | 0.00758725 | 8408-8410 |
| ORF1ab/nsp3 | 1897 | V1897I | V2715I | nonsyn | GtT | AtC | 659 | 1 | 0.00151745 | 8408-8410 |
Details of the mutation V1897I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 653 | 659 | All | 0.000125 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtA | 5 | 659 | All | 0.000001 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtC | 1 | 659 | All | 0 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 76 | 77 | B.1.617.2 | 0.000286 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtC | 1 | 77 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 76 | 76 | B.1.1.218 | 0.584615 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 55 | 55 | P.2 | 0.010265 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 48 | 48 | B.1.1.7 | 0.000043 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 32 | 32 | B.1.177.4 | 0.006754 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 32 | 32 | P.1.7 | 0.010217 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 29 | 29 | AY.4 | 0.000045 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 28 | 28 | B.1.1.72 | 0.848485 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 23 | 23 | AY.43 | 0.000102 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 20 | 20 | B.1.637 | 0.001461 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 18 | 18 | B.1.36.33 | 0.136364 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 14 | 14 | AY.25 | 0.000084 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 13 | 13 | B.1.160.29 | 0.054852 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 12 | 12 | AY.29 | 0.000189 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 11 | 12 | B.1.2 | 0.000097 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtA | 1 | 12 | B.1.2 | 0.000009 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 11 | 11 | AY.26 | 0.000311 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 11 | 11 | AY.3 | 0.000109 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 11 | 11 | B.1 | 0.000101 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 9 | 9 | AY.103 | 0.000056 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 9 | 9 | AY.121 | 0.001218 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 8 | 8 | B.1.177 | 0.000105 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 6 | 6 | AY.23 | 0.000418 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 6 | 6 | B.1.258 | 0.000399 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 5 | 5 | AY.113 | 0.000712 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | AY.39 | 0.000099 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | AY.46 | 0.000416 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | AY.6 | 0.000165 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | B.1.1 | 0.000073 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 4 | 4 | B.1.1.464 | 0.005891 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | AY.117 | 0.000254 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | AY.14 | 0.000264 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | AY.92 | 0.000862 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | AY.98.1 | 0.000145 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | B.1.1.28 | 0.000934 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | B.1.93 | 0.002801 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 3 | 3 | P.1 | 0.000047 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtA | 2 | 2 | 0.111111 | |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | B.1.258.7 | 0.003824 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | B.1.298 | 0.004228 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | B.1.595 | 0.000522 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | B.1.617.1 | 0.000258 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 2 | 2 | P.1.8 | 0.009569 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.12 | 0.000316 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.23.1 | 0.000417 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.42 | 0.00004 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.44 | 0.000006 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.49 | 0.003195 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.8 | 0.000606 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtA | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | AY.85 | 0.000427 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.1.48 | 0.002874 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.177.74 | 0.015152 |
| ORF1ab/nsp3 | 1897 | V1897I | GtT | AtA | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.399 | 0.001934 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | B.1.9.5 | 0.005682 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | C.35 | 0.000774 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | L.2 | 0.011364 |
| ORF1ab/nsp3 | 1897 | V1897I | Gtt | Att | 1 | 1 | P.1.15 | 0.000232 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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