CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = V1243I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 1243 | V1243I | V2061I | nonsyn | Gtt | Att | 1128 | 1127 | 0.999114 | 6446-6448 |
| ORF1ab/nsp3 | 1243 | V1243I | V2061I | nonsyn | GtT | AtC | 1128 | 1 | 0.000886525 | 6446-6448 |
Details of the mutation V1243I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1127 | 1128 | All | 0.000216 |
| ORF1ab/nsp3 | 1243 | V1243I | GtT | AtC | 1 | 1128 | All | 0 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 326 | 326 | AY.4 | 0.000507 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 248 | 248 | B.1.1.7 | 0.000222 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 87 | 87 | B.1.575 | 0.026396 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 62 | 62 | B.1 | 0.000568 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 29 | 29 | B.1.617.2 | 0.000109 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 23 | 23 | AY.103 | 0.000143 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 22 | 22 | B.1.2 | 0.000194 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 20 | 20 | AY.4.4 | 0.008183 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 19 | 19 | AY.25 | 0.000114 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 18 | 18 | AY.39 | 0.000445 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 13 | 13 | AY.43 | 0.000058 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 12 | 12 | B.1.420 | 0.125 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 11 | 11 | AY.27 | 0.000712 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 11 | 11 | AY.3 | 0.000109 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 11 | 11 | AY.47 | 0.000342 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 10 | 10 | AY.4.2 | 0.000217 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 9 | 9 | B.1.427 | 0.000454 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 8 | 8 | AY.102 | 0.000212 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 8 | 8 | B.1.177 | 0.000105 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 8 | 8 | P.1 | 0.000126 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 7 | 7 | AY.106 | 0.002344 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 7 | 7 | AY.29 | 0.00011 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 6 | 6 | B.1.1 | 0.000109 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 5 | 5 | AY.26 | 0.000142 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 5 | 5 | AY.42 | 0.000201 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 5 | 5 | AY.5 | 0.000103 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | AY.100 | 0.000184 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | AY.33 | 0.000267 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | AY.44 | 0.000024 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | AY.75.1 | 0.000721 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | AY.9 | 0.00027 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | B.1.568 | 0.004444 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 4 | 4 | N.5 | 0.007067 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.108 | 0.003308 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.2 | 0.001068 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.20 | 0.000117 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | AY.70 | 0.000626 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | B.1.243 | 0.000209 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | B.1.429 | 0.000071 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 3 | 3 | B.1.466.2 | 0.001174 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | A.23.1 | 0.001408 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.114 | 0.000462 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.118 | 0.000125 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.119 | 0.000071 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.36 | 0.000296 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.4.5 | 0.000215 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.5.3 | 0.000675 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.67 | 0.000929 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | AY.81 | 0.003984 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.1.159 | 0.009346 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.160 | 0.000062 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.224 | 0.05 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | B.1.621 | 0.000177 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | P.1.15 | 0.000465 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | P.1.4 | 0.001953 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 2 | 2 | Q.8 | 0.00033 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.109 | 0.00074 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.23.1 | 0.000417 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.29.1 | 0.000221 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.40 | 0.000964 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.5.4 | 0.000277 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.1.207 | 0.001182 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.1.27 | 0.00565 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.1.369 | 0.000446 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.1.435 | 0.034483 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.128 | 0.000635 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.213 | 0.014925 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.214.1 | 0.02 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.264 | 0.012346 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.302 | 0.013333 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.36.10 | 0.004785 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.36.17 | 0.000494 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.36.38 | 0.001642 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.564 | 0.000426 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.580 | 0.004065 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.620 | 0.000946 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.623 | 0.000536 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp3 | 1243 | V1243I | GtT | AtC | 1 | 1 | C.35 | 0.000774 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | P.2 | 0.000187 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | Q.3 | 0.000145 |
| ORF1ab/nsp3 | 1243 | V1243I | Gtt | Att | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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