CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = T1714I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 1714 | T1714I | T2532I | nonsyn | aCt | aTt | 1656 | 1656 | 1 | 7859-7861 |
Details of the mutation T1714I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1656 | 1656 | All | 0.000317 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 672 | 672 | B.1.1.7 | 0.000602 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 253 | 253 | P.1 | 0.003986 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 135 | 135 | B.1.243 | 0.009394 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 72 | 72 | AY.4 | 0.000112 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 61 | 61 | AY.26 | 0.001727 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 48 | 48 | AY.44 | 0.000292 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 33 | 33 | AY.102 | 0.000875 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 32 | 32 | AY.25 | 0.000192 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 29 | 29 | B.1.594 | 0.90625 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 28 | 28 | AZ.4 | 0.09396 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 23 | 23 | B.1.617.2 | 0.000087 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 21 | 21 | B.1.625 | 0.049412 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 18 | 18 | B.1 | 0.000165 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 14 | 14 | AY.103 | 0.000087 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 14 | 14 | B.1.1.519 | 0.000556 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 13 | 13 | AY.46.6 | 0.000939 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 9 | 9 | B.1.1.466 | 0.078261 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 9 | 9 | B.1.2 | 0.000079 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 9 | 9 | B.1.526 | 0.000212 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 8 | 8 | A.2 | 0.005295 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 6 | 6 | B.1.1 | 0.000109 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 6 | 6 | B.1.1.284 | 0.000644 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 5 | 5 | AY.29.1 | 0.001103 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 5 | 5 | B.1.177.35 | 0.003455 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 5 | 5 | B.1.429 | 0.000118 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 5 | 5 | C.37 | 0.00058 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 4 | 4 | AY.39 | 0.000099 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 4 | 4 | B.1.177 | 0.000053 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 4 | 4 | P.1.15 | 0.000929 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | AY.3 | 0.00003 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | AY.39.2 | 0.004622 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | AY.43 | 0.000013 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | AY.58 | 0.002722 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.1.318 | 0.000905 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.221 | 0.000213 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.36 | 0.000438 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.438.1 | 0.000322 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.446 | 0.06 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | B.1.588 | 0.00273 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 3 | 3 | C.32 | 0.069767 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.121 | 0.000271 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.9 | 0.000135 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | B.1.1.214 | 0.000111 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | B.6.6 | 0.001778 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 2 | 2 | P.1.14 | 0.000096 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | 0.055556 | |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | A.1 | 0.000282 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | A.2.5 | 0.000499 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | A.23.1 | 0.000704 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.20 | 0.000039 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.57 | 0.000656 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.60 | 0.000938 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.91 | 0.00073 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AY.99.2 | 0.000092 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | AZ.3 | 0.00152 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.216 | 0.00089 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.263 | 0.001558 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.33 | 0.000421 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.363 | 0.005988 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.37 | 0.000193 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.389 | 0.006061 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.397 | 0.002252 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.434 | 0.000349 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.1.44 | 0.00241 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.110.3 | 0.000718 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.177.65 | 0.000665 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.213 | 0.014925 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.258.3 | 0.001675 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.3 | 0.002618 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.362 | 0.001541 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | P.1.12 | 0.000484 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | Q.2 | 0.000613 |
| ORF1ab/nsp3 | 1714 | T1714I | aCt | aTt | 1 | 1 | Q.8 | 0.000165 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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