CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = S371L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3371S371LS1189LnonsynAGCTTA66450.6818183830-3832
ORF1ab/nsp3371S371LS1189LnonsynAGCTTG6670.1060613830-3832
ORF1ab/nsp3371S371LS1189LnonsynAGCCTA6670.1060613830-3832
ORF1ab/nsp3371S371LS1189LnonsynAGCCTT6670.1060613830-3832

Details of the mutation S371L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3371S371LAGCTTA4566All0.000009
ORF1ab/nsp3371S371LAGCTTG766All0.000001
ORF1ab/nsp3371S371LAGCCTA766All0.000001
ORF1ab/nsp3371S371LAGCCTT766All0.000001
ORF1ab/nsp3371S371LAGCTTA4160B.1.1.70.000037
ORF1ab/nsp3371S371LAGCTTG760B.1.1.70.000006
ORF1ab/nsp3371S371LAGCCTA660B.1.1.70.000005
ORF1ab/nsp3371S371LAGCCTT660B.1.1.70.000005
ORF1ab/nsp3371S371LAGCCTA13B.10.000009
ORF1ab/nsp3371S371LAGCTTA13B.10.000009
ORF1ab/nsp3371S371LAGCCTT13B.10.000009
ORF1ab/nsp3371S371LAGCTTA11AY.250.000006
ORF1ab/nsp3371S371LAGCTTA11B.1.5760.000907
ORF1ab/nsp3371S371LAGCTTA11P.10.000016

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.