CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = P74L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp374P74LP892LnonsyncCacTa8057980.9913042939-2941
ORF1ab/nsp374P74LP892LnonsynCCaTTa80540.004968942939-2941
ORF1ab/nsp374P74LP892LnonsyncCAcTG80530.003726712939-2941

Details of the mutation P74L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp374P74LcCacTa798805All0.000153
ORF1ab/nsp374P74LCCaTTa4805All0.000001
ORF1ab/nsp374P74LcCAcTG3805All0.000001
ORF1ab/nsp374P74LcCacTa176176B.1.2011
ORF1ab/nsp374P74LcCacTa104104B.1.1.70.000093
ORF1ab/nsp374P74LcCacTa4848B.1.617.20.000181
ORF1ab/nsp374P74LcCacTa3939AY.420.001569
ORF1ab/nsp374P74LcCacTa3334AY.40.000051
ORF1ab/nsp374P74LCCaTTa134AY.40.000002
ORF1ab/nsp374P74LcCacTa3030B.10.000275
ORF1ab/nsp374P74LcCacTa2727AY.1000.001242
ORF1ab/nsp374P74LcCacTa2727C.370.003134
ORF1ab/nsp374P74LcCacTa2323B.1.1.330.00968
ORF1ab/nsp374P74LcCacTa1616AY.1030.000099
ORF1ab/nsp374P74LcCacTa1515B.1.20.000132
ORF1ab/nsp374P74LcCacTa1414AY.30.000139
ORF1ab/nsp374P74LcCacTa1414AY.440.000085
ORF1ab/nsp374P74LcCacTa1313AY.60.000535
ORF1ab/nsp374P74LcCacTa1313B.1.36.160.018519
ORF1ab/nsp374P74LcCacTa1111B.400.004007
ORF1ab/nsp374P74LcCacTa1010Z.10.028902
ORF1ab/nsp374P74LcCacTa68AY.430.000027
ORF1ab/nsp374P74LcCAcTG28AY.430.000009
ORF1ab/nsp374P74LcCacTa88B.1.5260.000188
ORF1ab/nsp374P74LcCacTa77AY.250.000042
ORF1ab/nsp374P74LcCacTa77AY.4.20.000152
ORF1ab/nsp374P74LcCacTa77B.1.1.2220.001428
ORF1ab/nsp374P74LcCacTa66AY.260.00017
ORF1ab/nsp374P74LcCacTa66B.1.160.160.005576
ORF1ab/nsp374P74LcCacTa55AY.1190.000177
ORF1ab/nsp374P74LcCacTa55AY.220.01046
ORF1ab/nsp374P74LcCacTa55AY.230.000349
ORF1ab/nsp374P74LcCacTa55B.1.10.000091
ORF1ab/nsp374P74LcCacTa55B.1.1770.000066
ORF1ab/nsp374P74LcCacTa55B.1.617.10.000645
ORF1ab/nsp374P74LcCacTa55P.10.000079
ORF1ab/nsp374P74LcCacTa44AY.120.10.001284
ORF1ab/nsp374P74LcCacTa44B.1.3510.000119
ORF1ab/nsp374P74LcCacTa33AY.140.000264
ORF1ab/nsp374P74LcCacTa33AY.270.000194
ORF1ab/nsp374P74LcCacTa33AY.390.000074
ORF1ab/nsp374P74LcCacTa33AY.740.000347
ORF1ab/nsp374P74LcCacTa33AY.840.001312
ORF1ab/nsp374P74LcCacTa33AY.90.000203
ORF1ab/nsp374P74LcCacTa33B.1.1.630.001157
ORF1ab/nsp374P74LcCacTa33B.1.466.20.001174
ORF1ab/nsp374P74LcCacTa33B.1.4700.004213
ORF1ab/nsp374P74LcCacTa22AM.40.007143
ORF1ab/nsp374P74LcCacTa22AY.10.000791
ORF1ab/nsp374P74LcCacTa22AY.160.000759
ORF1ab/nsp374P74LcCacTa22AY.340.000194
ORF1ab/nsp374P74LcCacTa22AY.460.000208
ORF1ab/nsp374P74LcCAcTG12AY.670.000464
ORF1ab/nsp374P74LcCacTa12AY.670.000464
ORF1ab/nsp374P74LcCacTa22AY.710.00095
ORF1ab/nsp374P74LcCacTa22AY.750.000112
ORF1ab/nsp374P74LcCacTa22AY.9.10.000167
ORF1ab/nsp374P74LcCacTa22AY.99.20.000184
ORF1ab/nsp374P74LcCacTa22B.1.1.2840.000215
ORF1ab/nsp374P74LcCacTa22B.1.1.2940.002532
ORF1ab/nsp374P74LcCacTa22B.1.1600.000062
ORF1ab/nsp374P74LcCacTa22B.1.2580.000133
ORF1ab/nsp374P74LcCacTa22B.1.4270.000101
ORF1ab/nsp374P74LcCacTa22B.1.4290.000047
ORF1ab/nsp374P74LcCacTa11A.20.000662
ORF1ab/nsp374P74LcCacTa11AE.80.000489
ORF1ab/nsp374P74LcCacTa11AY.1060.000335
ORF1ab/nsp374P74LcCacTa11AY.130.000161
ORF1ab/nsp374P74LcCacTa11AY.200.000039
ORF1ab/nsp374P74LcCacTa11AY.240.000431
ORF1ab/nsp374P74LcCacTa11AY.290.000016
ORF1ab/nsp374P74LcCacTa11AY.3.10.000085
ORF1ab/nsp374P74LcCacTa11AY.380.000499
ORF1ab/nsp374P74LcCacTa11AY.4.50.000107
ORF1ab/nsp374P74LcCacTa11AY.46.60.000072
ORF1ab/nsp374P74LcCacTa11AY.470.000031
ORF1ab/nsp374P74LcCacTa11AY.50.000021
ORF1ab/nsp374P74LcCacTa11AY.540.000095
ORF1ab/nsp374P74LcCacTa11AY.600.000938
ORF1ab/nsp374P74LcCacTa11AY.650.000533
ORF1ab/nsp374P74LcCacTa11AY.7.10.000113
ORF1ab/nsp374P74LcCacTa11AY.9.20.000037
ORF1ab/nsp374P74LcCacTa11AY.980.000079
ORF1ab/nsp374P74LcCacTa11B.1.1.10.000327
ORF1ab/nsp374P74LcCacTa11B.1.1.1110.014706
ORF1ab/nsp374P74LCCaTTa11B.1.1.1890.001513
ORF1ab/nsp374P74LcCacTa11B.1.1.250.000569
ORF1ab/nsp374P74LcCacTa11B.1.1.3110.000358
ORF1ab/nsp374P74LcCacTa11B.1.1.3180.000302
ORF1ab/nsp374P74LcCacTa11B.1.1.3620.005618
ORF1ab/nsp374P74LcCacTa11B.1.1.5190.00004
ORF1ab/nsp374P74LcCacTa11B.1.1.5240.020833
ORF1ab/nsp374P74LcCacTa11B.1.2320.000537
ORF1ab/nsp374P74LcCacTa11B.1.3330.010526
ORF1ab/nsp374P74LcCacTa11B.1.360.000146
ORF1ab/nsp374P74LCCaTTa11B.1.4160.001269
ORF1ab/nsp374P74LcCacTa11B.1.4590.004082
ORF1ab/nsp374P74LcCacTa11B.1.5820.000491
ORF1ab/nsp374P74LCCaTTa11B.1.6210.000089
ORF1ab/nsp374P74LcCacTa11C.360.000911
ORF1ab/nsp374P74LcCacTa11N.30.005814
ORF1ab/nsp374P74LcCacTa11P.1.140.000048
ORF1ab/nsp374P74LcCacTa11P.1.150.000232
ORF1ab/nsp374P74LcCacTa11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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