CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = P723L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3723P723LP1541LnonsyncCtcTt7417390.9973014886-4888
ORF1ab/nsp3723P723LP1541LnonsyncCTcTA74120.002699064886-4888

Details of the mutation P723L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3723P723LcCtcTt739741All0.000141
ORF1ab/nsp3723P723LcCTcTA2741All0
ORF1ab/nsp3723P723LcCtcTt306306AY.50.006319
ORF1ab/nsp3723P723LcCtcTt120120B.1.1.70.000107
ORF1ab/nsp3723P723LcCtcTt7575AY.40.000117
ORF1ab/nsp3723P723LcCtcTt3940B.1.617.20.000147
ORF1ab/nsp3723P723LcCTcTA140B.1.617.20.000004
ORF1ab/nsp3723P723LcCtcTt1515AY.250.00009
ORF1ab/nsp3723P723LcCtcTt1212AY.30.000119
ORF1ab/nsp3723P723LcCtcTt1010AY.440.000061
ORF1ab/nsp3723P723LcCtcTt88AY.420.000322
ORF1ab/nsp3723P723LcCtcTt77AY.1030.000043
ORF1ab/nsp3723P723LcCtcTt77Q.30.001015
ORF1ab/nsp3723P723LcCtcTt66AY.1020.000159
ORF1ab/nsp3723P723LcCtcTt55AY.1110.000916
ORF1ab/nsp3723P723LcCtcTt55AY.1190.000177
ORF1ab/nsp3723P723LcCtcTt55AY.140.00044
ORF1ab/nsp3723P723LcCtcTt55AY.430.000022
ORF1ab/nsp3723P723LcCtcTt55B.10.000046
ORF1ab/nsp3723P723LcCtcTt55B.1.20.000044
ORF1ab/nsp3723P723LcCtcTt55D.20.000375
ORF1ab/nsp3723P723LcCtcTt44AY.39.10.000158
ORF1ab/nsp3723P723LcCtcTt44AY.98.10.000194
ORF1ab/nsp3723P723LcCtcTt44B.1.1600.000125
ORF1ab/nsp3723P723LcCtcTt44P.10.000063
ORF1ab/nsp3723P723LcCtcTt33AY.980.000237
ORF1ab/nsp3723P723LcCtcTt33B.1.1.2140.000166
ORF1ab/nsp3723P723LcCtcTt33B.1.1770.00004
ORF1ab/nsp3723P723LcCtcTt33B.1.177.750.003122
ORF1ab/nsp3723P723LcCtcTt33B.1.177.810.000568
ORF1ab/nsp3723P723LcCtcTt22AY.1170.000169
ORF1ab/nsp3723P723LcCtcTt22AY.380.000999
ORF1ab/nsp3723P723LcCtcTt22AY.4.20.000043
ORF1ab/nsp3723P723LcCtcTt22AY.700.000417
ORF1ab/nsp3723P723LcCtcTt22AY.90.000135
ORF1ab/nsp3723P723LcCtcTt12B0.000128
ORF1ab/nsp3723P723LcCTcTA12B0.000128
ORF1ab/nsp3723P723LcCtcTt22B.1.10.000036
ORF1ab/nsp3723P723LcCtcTt22B.1.1.2790.002242
ORF1ab/nsp3723P723LcCtcTt22B.1.4290.000047
ORF1ab/nsp3723P723LcCtcTt22Q.10.000253
ORF1ab/nsp3723P723LcCtcTt11AY.10.000396
ORF1ab/nsp3723P723LcCtcTt11AY.1060.000335
ORF1ab/nsp3723P723LcCtcTt11AY.1180.000063
ORF1ab/nsp3723P723LcCtcTt11AY.1200.000037
ORF1ab/nsp3723P723LcCtcTt11AY.120.10.000321
ORF1ab/nsp3723P723LcCtcTt11AY.130.000161
ORF1ab/nsp3723P723LcCtcTt11AY.200.000039
ORF1ab/nsp3723P723LcCtcTt11AY.290.000016
ORF1ab/nsp3723P723LcCtcTt11AY.3.10.000085
ORF1ab/nsp3723P723LcCtcTt11AY.330.000067
ORF1ab/nsp3723P723LcCtcTt11AY.350.000233
ORF1ab/nsp3723P723LcCtcTt11AY.390.000025
ORF1ab/nsp3723P723LcCtcTt11AY.39.1.10.000725
ORF1ab/nsp3723P723LcCtcTt11AY.4.2.10.000149
ORF1ab/nsp3723P723LcCtcTt11AY.5.40.000277
ORF1ab/nsp3723P723LcCtcTt11AY.540.000095
ORF1ab/nsp3723P723LcCtcTt11AY.550.000917
ORF1ab/nsp3723P723LcCtcTt11AY.60.000041
ORF1ab/nsp3723P723LcCtcTt11AY.880.000884
ORF1ab/nsp3723P723LcCtcTt11AY.910.00073
ORF1ab/nsp3723P723LcCtcTt11B.1.1.280.000311
ORF1ab/nsp3723P723LcCtcTt11B.1.1.2890.002083
ORF1ab/nsp3723P723LcCtcTt11B.1.1.4190.007407
ORF1ab/nsp3723P723LcCtcTt11B.1.1.5190.00004
ORF1ab/nsp3723P723LcCtcTt11B.1.177.160.000664
ORF1ab/nsp3723P723LcCtcTt11B.1.177.40.000211
ORF1ab/nsp3723P723LcCtcTt11B.1.177.410.0025
ORF1ab/nsp3723P723LcCtcTt11B.1.1820.007246
ORF1ab/nsp3723P723LcCtcTt11B.1.2210.000071
ORF1ab/nsp3723P723LcCtcTt11B.1.2320.000537
ORF1ab/nsp3723P723LcCtcTt11B.1.2340.000132
ORF1ab/nsp3723P723LcCtcTt11B.1.2390.001221
ORF1ab/nsp3723P723LcCtcTt11B.1.2430.00007
ORF1ab/nsp3723P723LcCtcTt11B.1.3110.000275
ORF1ab/nsp3723P723LcCtcTt11B.1.3510.00003
ORF1ab/nsp3723P723LcCtcTt11B.1.36.170.000494
ORF1ab/nsp3723P723LcCtcTt11B.1.3690.000285
ORF1ab/nsp3723P723LcCtcTt11B.1.4000.000429
ORF1ab/nsp3723P723LcCtcTt11B.1.4270.00005
ORF1ab/nsp3723P723LcCtcTt11B.1.438.10.000107
ORF1ab/nsp3723P723LcCtcTt11B.1.4530.003236
ORF1ab/nsp3723P723LcCtcTt11B.1.5250.000113
ORF1ab/nsp3723P723LcCtcTt11B.1.5760.000907
ORF1ab/nsp3723P723LcCtcTt11B.1.5820.000491
ORF1ab/nsp3723P723LcCtcTt11B.1.5950.000261
ORF1ab/nsp3723P723LcCtcTt11B.1.617.10.000129
ORF1ab/nsp3723P723LcCtcTt11B.30.000831
ORF1ab/nsp3723P723LcCtcTt11P.1.170.000162
ORF1ab/nsp3723P723LcCtcTt11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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