CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = P512L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3512P512LP1330LnonsyncCgcTg37260.7027034253-4255
ORF1ab/nsp3512P512LP1330LnonsyncCGcTT3740.1081084253-4255
ORF1ab/nsp3512P512LP1330LnonsyncCGcTA3740.1081084253-4255
ORF1ab/nsp3512P512LP1330LnonsynCCGTTA3720.05405414253-4255
ORF1ab/nsp3512P512LP1330LnonsyncCGcTC3710.0270274253-4255

Details of the mutation P512L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3512P512LcCgcTg2637All0.000005
ORF1ab/nsp3512P512LcCGcTA437All0.000001
ORF1ab/nsp3512P512LcCGcTT437All0.000001
ORF1ab/nsp3512P512LCCGTTA237All0
ORF1ab/nsp3512P512LcCGcTC137All0
ORF1ab/nsp3512P512LcCGcTA490.222222
ORF1ab/nsp3512P512LcCgcTg290.111111
ORF1ab/nsp3512P512LCCGTTA290.111111
ORF1ab/nsp3512P512LcCGcTC190.055556
ORF1ab/nsp3512P512LcCgcTg45B.10.000037
ORF1ab/nsp3512P512LcCGcTT15B.10.000009
ORF1ab/nsp3512P512LcCgcTg44B.1.1.70.000004
ORF1ab/nsp3512P512LcCgcTg23B.1.20.000018
ORF1ab/nsp3512P512LcCGcTT13B.1.20.000009
ORF1ab/nsp3512P512LcCgcTg33B.1.617.20.000011
ORF1ab/nsp3512P512LcCgcTg22AY.1030.000012
ORF1ab/nsp3512P512LcCgcTg22AY.1200.000074
ORF1ab/nsp3512P512LcCgcTg22AY.430.000009
ORF1ab/nsp3512P512LcCgcTg22AY.440.000012
ORF1ab/nsp3512P512LcCgcTg11AY.540.000095
ORF1ab/nsp3512P512LcCGcTT11AY.610.000105
ORF1ab/nsp3512P512LcCgcTg11B.1.1.2140.000055
ORF1ab/nsp3512P512LcCgcTg11B.1.1600.000031
ORF1ab/nsp3512P512LcCGcTT11B.1.177.70.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.