CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = L327F

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3327L327FL1145FnonsynCttTtt57657613698-3700

Details of the mutation L327F within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3327L327FCttTtt576576All0.00011
ORF1ab/nsp3327L327FCttTtt7878B.1.36.330.590909
ORF1ab/nsp3327L327FCttTtt6969B.1.1.70.000062
ORF1ab/nsp3327L327FCttTtt4242AY.40.000065
ORF1ab/nsp3327L327FCttTtt3939P.20.007279
ORF1ab/nsp3327L327FCttTtt3131B.1.177.210.002371
ORF1ab/nsp3327L327FCttTtt2929B.1.10.000526
ORF1ab/nsp3327L327FCttTtt2929B.1.617.20.000109
ORF1ab/nsp3327L327FCttTtt2222B.1.5260.000517
ORF1ab/nsp3327L327FCttTtt2121AY.430.000093
ORF1ab/nsp3327L327FCttTtt1515AY.250.00009
ORF1ab/nsp3327L327FCttTtt1313AY.1030.000081
ORF1ab/nsp3327L327FCttTtt1313B.1.20.000114
ORF1ab/nsp3327L327FCttTtt1212Q.10.001516
ORF1ab/nsp3327L327FCttTtt1010AZ.30.015198
ORF1ab/nsp3327L327FCttTtt1010B.1.1.2220.00204
ORF1ab/nsp3327L327FCttTtt99B.10.000082
ORF1ab/nsp3327L327FCttTtt88B.1.1600.00025
ORF1ab/nsp3327L327FCttTtt77B.1.1770.000092
ORF1ab/nsp3327L327FCttTtt66AY.440.000037
ORF1ab/nsp3327L327FCttTtt66P.10.000095
ORF1ab/nsp3327L327FCttTtt55AY.1020.000133
ORF1ab/nsp3327L327FCttTtt55AY.610.000524
ORF1ab/nsp3327L327FCttTtt44AY.1190.000141
ORF1ab/nsp3327L327FCttTtt44AY.4.20.000087
ORF1ab/nsp3327L327FCttTtt44B.1.6370.000292
ORF1ab/nsp3327L327FCttTtt33AY.200.000117
ORF1ab/nsp3327L327FCttTtt33B.1.1.2770.002276
ORF1ab/nsp3327L327FCttTtt33B.1.4290.000071
ORF1ab/nsp3327L327FCttTtt22AY.1010.000981
ORF1ab/nsp3327L327FCttTtt22AY.290.000032
ORF1ab/nsp3327L327FCttTtt22AY.330.000134
ORF1ab/nsp3327L327FCttTtt22AY.390.000049
ORF1ab/nsp3327L327FCttTtt22AY.450.000243
ORF1ab/nsp3327L327FCttTtt22B.1.1.1250.020408
ORF1ab/nsp3327L327FCttTtt22B.1.177.350.001382
ORF1ab/nsp3327L327FCttTtt22B.1.177.420.001789
ORF1ab/nsp3327L327FCttTtt11AL.10.012987
ORF1ab/nsp3327L327FCttTtt11AP.10.001502
ORF1ab/nsp3327L327FCttTtt11AY.1050.000643
ORF1ab/nsp3327L327FCttTtt11AY.1060.000335
ORF1ab/nsp3327L327FCttTtt11AY.1100.000113
ORF1ab/nsp3327L327FCttTtt11AY.1140.000231
ORF1ab/nsp3327L327FCttTtt11AY.1200.000037
ORF1ab/nsp3327L327FCttTtt11AY.120.10.000321
ORF1ab/nsp3327L327FCttTtt11AY.140.000088
ORF1ab/nsp3327L327FCttTtt11AY.370.000316
ORF1ab/nsp3327L327FCttTtt11AY.39.10.00004
ORF1ab/nsp3327L327FCttTtt11AY.4.2.10.000149
ORF1ab/nsp3327L327FCttTtt11AY.420.00004
ORF1ab/nsp3327L327FCttTtt11AY.46.30.000934
ORF1ab/nsp3327L327FCttTtt11AY.470.000031
ORF1ab/nsp3327L327FCttTtt11AY.50.000021
ORF1ab/nsp3327L327FCttTtt11AY.60.000041
ORF1ab/nsp3327L327FCttTtt11AY.750.000056
ORF1ab/nsp3327L327FCttTtt11AY.790.001211
ORF1ab/nsp3327L327FCttTtt11AY.9.10.000084
ORF1ab/nsp3327L327FCttTtt11AY.9.20.000037
ORF1ab/nsp3327L327FCttTtt11AY.910.00073
ORF1ab/nsp3327L327FCttTtt11AY.99.20.000092
ORF1ab/nsp3327L327FCttTtt11B.1.1.1530.001095
ORF1ab/nsp3327L327FCttTtt11B.1.1.1630.007634
ORF1ab/nsp3327L327FCttTtt11B.1.1.280.000311
ORF1ab/nsp3327L327FCttTtt11B.1.1.3260.001761
ORF1ab/nsp3327L327FCttTtt11B.1.1.3700.012658
ORF1ab/nsp3327L327FCttTtt11B.1.1.3880.045455
ORF1ab/nsp3327L327FCttTtt11B.1.1.4340.000349
ORF1ab/nsp3327L327FCttTtt11B.1.1.5190.00004
ORF1ab/nsp3327L327FCttTtt11B.1.1.5230.001563
ORF1ab/nsp3327L327FCttTtt11B.1.1.630.000386
ORF1ab/nsp3327L327FCttTtt11B.1.160.200.008929
ORF1ab/nsp3327L327FCttTtt11B.1.160.330.004425
ORF1ab/nsp3327L327FCttTtt11B.1.177.530.002392
ORF1ab/nsp3327L327FCttTtt11B.1.177.600.000218
ORF1ab/nsp3327L327FCttTtt11B.1.177.830.001481
ORF1ab/nsp3327L327FCttTtt11B.1.2340.000132
ORF1ab/nsp3327L327FCttTtt11B.1.2400.000216
ORF1ab/nsp3327L327FCttTtt11B.1.243.20.014493
ORF1ab/nsp3327L327FCttTtt11B.1.2580.000067
ORF1ab/nsp3327L327FCttTtt11B.1.258.170.000104
ORF1ab/nsp3327L327FCttTtt11B.1.3050.002151
ORF1ab/nsp3327L327FCttTtt11B.1.3240.001605
ORF1ab/nsp3327L327FCttTtt11B.1.3490.000715
ORF1ab/nsp3327L327FCttTtt11B.1.3510.00003
ORF1ab/nsp3327L327FCttTtt11B.1.438.10.000107
ORF1ab/nsp3327L327FCttTtt11B.1.4800.002488
ORF1ab/nsp3327L327FCttTtt11B.1.5240.001406
ORF1ab/nsp3327L327FCttTtt11B.1.5250.000113
ORF1ab/nsp3327L327FCttTtt11B.1.5900.004545
ORF1ab/nsp3327L327FCttTtt11B.1.6210.000089
ORF1ab/nsp3327L327FCttTtt11B.1.6320.006711
ORF1ab/nsp3327L327FCttTtt11C.36.3.10.002717
ORF1ab/nsp3327L327FCttTtt11C.370.000116
ORF1ab/nsp3327L327FCttTtt11C.80.004464
ORF1ab/nsp3327L327FCttTtt11P.1.140.000048
ORF1ab/nsp3327L327FCttTtt11P.1.150.000232
ORF1ab/nsp3327L327FCttTtt11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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