CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = L1277L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp31277L1277LL2095LsynCtaTta182216500.9055986548-6550
ORF1ab/nsp31277L1277LL2095LsynctActG18221490.08177836548-6550
ORF1ab/nsp31277L1277LL2095LsynctActC1822170.009330416548-6550
ORF1ab/nsp31277L1277LL2095LsynctActT182260.003293086548-6550

Details of the mutation L1277L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp31277L1277LCtaTta16501822All0.000316
ORF1ab/nsp31277L1277LctActG1491822All0.000028
ORF1ab/nsp31277L1277LctActC171822All0.000003
ORF1ab/nsp31277L1277LctActT61822All0.000001
ORF1ab/nsp31277L1277LCtaTta390466B.1.1.70.000349
ORF1ab/nsp31277L1277LctActG75466B.1.1.70.000067
ORF1ab/nsp31277L1277LctActT1466B.1.1.70.000001
ORF1ab/nsp31277L1277LCtaTta190202AY.40.000296
ORF1ab/nsp31277L1277LctActG12202AY.40.000019
ORF1ab/nsp31277L1277LCtaTta9495P.10.001481
ORF1ab/nsp31277L1277LctActG195P.10.000016
ORF1ab/nsp31277L1277LCtaTta8787AY.230.006068
ORF1ab/nsp31277L1277LCtaTta6668AY.430.000292
ORF1ab/nsp31277L1277LctActT168AY.430.000004
ORF1ab/nsp31277L1277LctActG168AY.430.000004
ORF1ab/nsp31277L1277LCtaTta5960AY.1020.001564
ORF1ab/nsp31277L1277LctActG160AY.1020.000027
ORF1ab/nsp31277L1277LCtaTta5358B.1.617.20.0002
ORF1ab/nsp31277L1277LctActG458B.1.617.20.000015
ORF1ab/nsp31277L1277LctActT158B.1.617.20.000004
ORF1ab/nsp31277L1277LCtaTta5456AY.250.000325
ORF1ab/nsp31277L1277LctActG256AY.250.000012
ORF1ab/nsp31277L1277LCtaTta5355B.1.20.000467
ORF1ab/nsp31277L1277LctActG255B.1.20.000018
ORF1ab/nsp31277L1277LCtaTta4343B.1.2210.003054
ORF1ab/nsp31277L1277LCtaTta4040B.1.1600.001248
ORF1ab/nsp31277L1277LCtaTta2829AY.440.00017
ORF1ab/nsp31277L1277LctActC129AY.440.000006
ORF1ab/nsp31277L1277LCtaTta2929B.1.5940.90625
ORF1ab/nsp31277L1277LCtaTta2727B.1.1.3070.068354
ORF1ab/nsp31277L1277LctActG1623AY.30.000159
ORF1ab/nsp31277L1277LCtaTta723AY.30.00007
ORF1ab/nsp31277L1277LCtaTta2223B.1.10.000399
ORF1ab/nsp31277L1277LctActC123B.1.10.000018
ORF1ab/nsp31277L1277LCtaTta2222A.2.5.20.034591
ORF1ab/nsp31277L1277LCtaTta1922B.10.000174
ORF1ab/nsp31277L1277LctActC122B.10.000009
ORF1ab/nsp31277L1277LctActG122B.10.000009
ORF1ab/nsp31277L1277LctActT122B.10.000009
ORF1ab/nsp31277L1277LCtaTta2020AY.470.000622
ORF1ab/nsp31277L1277LCtaTta2020B.1.177.40.004221
ORF1ab/nsp31277L1277LCtaTta2020B.1.4290.000471
ORF1ab/nsp31277L1277LCtaTta1718AY.3.10.001449
ORF1ab/nsp31277L1277LctActG118AY.3.10.000085
ORF1ab/nsp31277L1277LCtaTta1718AY.46.60.001228
ORF1ab/nsp31277L1277LctActC118AY.46.60.000072
ORF1ab/nsp31277L1277LCtaTta1717AY.1110.003114
ORF1ab/nsp31277L1277LCtaTta1215AY.1030.000075
ORF1ab/nsp31277L1277LctActG315AY.1030.000019
ORF1ab/nsp31277L1277LCtaTta1213B.1.1770.000158
ORF1ab/nsp31277L1277LctActC113B.1.1770.000013
ORF1ab/nsp31277L1277LctActG1112AY.450.001339
ORF1ab/nsp31277L1277LCtaTta112AY.450.000122
ORF1ab/nsp31277L1277LCtaTta1212B.1.4270.000606
ORF1ab/nsp31277L1277LCtaTta1011B.1.3510.000297
ORF1ab/nsp31277L1277LctActG111B.1.3510.00003
ORF1ab/nsp31277L1277LCtaTta710B.1.5260.000165
ORF1ab/nsp31277L1277LctActG310B.1.5260.000071
ORF1ab/nsp31277L1277LCtaTta99AY.290.000142
ORF1ab/nsp31277L1277LctActG88B.1.1.2770.00607
ORF1ab/nsp31277L1277LCtaTta77AY.260.000198
ORF1ab/nsp31277L1277LCtaTta77AY.390.000173
ORF1ab/nsp31277L1277LCtaTta57AY.50.000103
ORF1ab/nsp31277L1277LctActC27AY.50.000041
ORF1ab/nsp31277L1277LCtaTta66B.1.1.2220.001224
ORF1ab/nsp31277L1277LCtaTta66B.1.351.30.005259
ORF1ab/nsp31277L1277LCtaTta55AY.140.00044
ORF1ab/nsp31277L1277LCtaTta55AY.4.20.000108
ORF1ab/nsp31277L1277LCtaTta55AY.610.000524
ORF1ab/nsp31277L1277LCtaTta55B.1.1.2630.007788
ORF1ab/nsp31277L1277LCtaTta44AY.16.10.00188
ORF1ab/nsp31277L1277LCtaTta44AY.330.000267
ORF1ab/nsp31277L1277LCtaTta44AY.360.000593
ORF1ab/nsp31277L1277LCtaTta44AY.46.40.000658
ORF1ab/nsp31277L1277LCtaTta44AY.60.000165
ORF1ab/nsp31277L1277LctActC44B.1.1.460.017467
ORF1ab/nsp31277L1277LCtaTta44B.1.6210.000354
ORF1ab/nsp31277L1277LCtaTta44C.36.30.002269
ORF1ab/nsp31277L1277LCtaTta33A.280.007937
ORF1ab/nsp31277L1277LCtaTta33AY.1160.00086
ORF1ab/nsp31277L1277LCtaTta33AY.740.000347
ORF1ab/nsp31277L1277LCtaTta33AY.98.10.000145
ORF1ab/nsp31277L1277LCtaTta33B.1.1620.015075
ORF1ab/nsp31277L1277LCtaTta33B.1.36.10.003421
ORF1ab/nsp31277L1277LCtaTta33B.1.3710.003367
ORF1ab/nsp31277L1277LCtaTta33B.1.4460.06
ORF1ab/nsp31277L1277LctActG33B.1.6090.001438
ORF1ab/nsp31277L1277LCtaTta33P.1.140.000143
ORF1ab/nsp31277L1277LCtaTta22A.2.50.000998
ORF1ab/nsp31277L1277LCtaTta22AY.1000.000092
ORF1ab/nsp31277L1277LCtaTta22AY.1170.000169
ORF1ab/nsp31277L1277LCtaTta22AY.1200.000074
ORF1ab/nsp31277L1277LCtaTta22AY.300.000791
ORF1ab/nsp31277L1277LCtaTta22AY.380.000999
ORF1ab/nsp31277L1277LCtaTta22AY.39.10.000079
ORF1ab/nsp31277L1277LCtaTta22AY.530.000575
ORF1ab/nsp31277L1277LCtaTta22AY.620.000871
ORF1ab/nsp31277L1277LCtaTta22AY.660.002139
ORF1ab/nsp31277L1277LCtaTta22AY.7.10.000225
ORF1ab/nsp31277L1277LCtaTta22AY.790.002421
ORF1ab/nsp31277L1277LCtaTta12AY.840.000437
ORF1ab/nsp31277L1277LctActC12AY.840.000437
ORF1ab/nsp31277L1277LctActC12AY.9.20.000037
ORF1ab/nsp31277L1277LCtaTta12AY.9.20.000037
ORF1ab/nsp31277L1277LCtaTta22B0.000256
ORF1ab/nsp31277L1277LCtaTta22B.1.160.280.005848
ORF1ab/nsp31277L1277LCtaTta22B.1.2340.000264
ORF1ab/nsp31277L1277LCtaTta22B.1.2430.000139
ORF1ab/nsp31277L1277LCtaTta12R.10.00009
ORF1ab/nsp31277L1277LctActG12R.10.00009
ORF1ab/nsp31277L1277LCtaTta11AE.80.000489
ORF1ab/nsp31277L1277LCtaTta11AY.100.00053
ORF1ab/nsp31277L1277LCtaTta11AY.1090.00074
ORF1ab/nsp31277L1277LCtaTta11AY.1190.000035
ORF1ab/nsp31277L1277LCtaTta11AY.1210.000135
ORF1ab/nsp31277L1277LCtaTta11AY.150.002222
ORF1ab/nsp31277L1277LctActG11AY.200.000039
ORF1ab/nsp31277L1277LCtaTta11AY.350.000233
ORF1ab/nsp31277L1277LCtaTta11AY.370.000316
ORF1ab/nsp31277L1277LctActG11AY.39.20.001541
ORF1ab/nsp31277L1277LCtaTta11AY.420.00004
ORF1ab/nsp31277L1277LCtaTta11AY.500.000799
ORF1ab/nsp31277L1277LCtaTta11AY.540.000095
ORF1ab/nsp31277L1277LCtaTta11AY.700.000209
ORF1ab/nsp31277L1277LCtaTta11AY.750.000056
ORF1ab/nsp31277L1277LCtaTta11AY.75.10.00018
ORF1ab/nsp31277L1277LCtaTta11AY.870.000833
ORF1ab/nsp31277L1277LCtaTta11AY.90.000068
ORF1ab/nsp31277L1277LCtaTta11AY.900.000684
ORF1ab/nsp31277L1277LCtaTta11AY.980.000079
ORF1ab/nsp31277L1277LCtaTta11AZ.10.000867
ORF1ab/nsp31277L1277LCtaTta11B.1.1.10.000327
ORF1ab/nsp31277L1277LCtaTta11B.1.1.1530.001095
ORF1ab/nsp31277L1277LctActG11B.1.1.2140.000055
ORF1ab/nsp31277L1277LCtaTta11B.1.1.2410.00207
ORF1ab/nsp31277L1277LCtaTta11B.1.1.250.000569
ORF1ab/nsp31277L1277LCtaTta11B.1.1.280.000311
ORF1ab/nsp31277L1277LctActC11B.1.1.3000.010753
ORF1ab/nsp31277L1277LCtaTta11B.1.1.3180.000302
ORF1ab/nsp31277L1277LctActC11B.1.1.370.000193
ORF1ab/nsp31277L1277LCtaTta11B.1.1.3720.000689
ORF1ab/nsp31277L1277LCtaTta11B.1.1.3970.002252
ORF1ab/nsp31277L1277LCtaTta11B.1.1.500.000679
ORF1ab/nsp31277L1277LCtaTta11B.1.1.5230.001563
ORF1ab/nsp31277L1277LCtaTta11B.1.1.700.000341
ORF1ab/nsp31277L1277LCtaTta11B.1.1470.000756
ORF1ab/nsp31277L1277LCtaTta11B.1.177.190.001431
ORF1ab/nsp31277L1277LCtaTta11B.1.177.440.000519
ORF1ab/nsp31277L1277LCtaTta11B.1.177.570.000281
ORF1ab/nsp31277L1277LctActC11B.1.177.60.000977
ORF1ab/nsp31277L1277LCtaTta11B.1.177.600.000218
ORF1ab/nsp31277L1277LCtaTta11B.1.177.820.000477
ORF1ab/nsp31277L1277LCtaTta11B.1.2400.000216
ORF1ab/nsp31277L1277LctActT11B.1.2580.000067
ORF1ab/nsp31277L1277LCtaTta11B.1.2770.02381
ORF1ab/nsp31277L1277LctActT11B.1.3200.001245
ORF1ab/nsp31277L1277LCtaTta11B.1.351.20.000303
ORF1ab/nsp31277L1277LCtaTta11B.1.360.000146
ORF1ab/nsp31277L1277LCtaTta11B.1.36.290.000517
ORF1ab/nsp31277L1277LCtaTta11B.1.3960.000706
ORF1ab/nsp31277L1277LCtaTta11B.1.4010.008197
ORF1ab/nsp31277L1277LCtaTta11B.1.466.20.000391
ORF1ab/nsp31277L1277LctActC11B.1.5610.000397
ORF1ab/nsp31277L1277LCtaTta11B.1.5970.00463
ORF1ab/nsp31277L1277LCtaTta11B.1.6340.003425
ORF1ab/nsp31277L1277LCtaTta11B.1.6370.000073
ORF1ab/nsp31277L1277LCtaTta11B.1.930.000934
ORF1ab/nsp31277L1277LCtaTta11B.100.008264
ORF1ab/nsp31277L1277LCtaTta11P.1.150.000232
ORF1ab/nsp31277L1277LCtaTta11P.1.170.000162
ORF1ab/nsp31277L1277LCtaTta11P.50.013699

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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