CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = K1241R
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 1241 | K1241R | K2059R | nonsyn | aAa | aGa | 8230 | 8228 | 0.999757 | 6440-6442 |
| ORF1ab/nsp3 | 1241 | K1241R | K2059R | nonsyn | aAA | aGG | 8230 | 2 | 0.000243013 | 6440-6442 |
Details of the mutation K1241R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 8228 | 8230 | All | 0.001574 |
| ORF1ab/nsp3 | 1241 | K1241R | aAA | aGG | 2 | 8230 | All | 0 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 7420 | 7420 | B.1.234 | 0.979021 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 334 | 334 | B.1 | 0.003059 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 165 | 165 | B.1.2 | 0.001453 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 40 | 40 | AY.25 | 0.000241 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 40 | 40 | B.1.596 | 0.003486 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 30 | 30 | AY.75 | 0.001681 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 21 | 21 | AY.4 | 0.000033 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 16 | 16 | B.1.1.7 | 0.000014 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 12 | 12 | B.1.575.2 | 0.057692 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 10 | 10 | B.1.617.2 | 0.000038 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 9 | 9 | B.1.1 | 0.000163 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 9 | 9 | B.1.240 | 0.00194 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 8 | 8 | B.1.243 | 0.000557 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 8 | 8 | B.1.595 | 0.002088 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 7 | 7 | B.1.221 | 0.000497 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 7 | 7 | B.1.396 | 0.00494 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 5 | 5 | B.1.541 | 0.022124 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 5 | 5 | B.1.580 | 0.020325 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 4 | 4 | AY.44 | 0.000024 |
| ORF1ab/nsp3 | 1241 | K1241R | aAA | aGG | 2 | 4 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 4 | B.1.1.519 | 0.000079 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 4 | 4 | B.1.349 | 0.002859 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 3 | 3 | AY.3 | 0.00003 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 3 | 3 | B.1.1.231 | 0.009288 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 3 | 3 | B.1.206 | 0.002447 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.324 | 0.00321 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.36.10 | 0.009569 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.417 | 0.057143 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.569 | 0.028986 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | B.1.612 | 0.005305 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 2 | 2 | P.2 | 0.000373 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | A.2 | 0.000662 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.103 | 0.000006 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.118 | 0.000063 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.222 | 0.000204 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.244 | 0.015385 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.329 | 0.003846 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.448 | 0.002033 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.507 | 0.008696 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.1.518 | 0.006329 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.139 | 0.000733 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.179 | 0.003759 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.239 | 0.001221 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.248 | 0.029412 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.265 | 0.001271 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.305 | 0.002151 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.325 | 0.006897 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.36.26 | 0.002857 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.375 | 0.00082 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.443 | 0.004673 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.521 | 0.004975 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.556 | 0.007519 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.566 | 0.019231 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.567 | 0.003333 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.577 | 0.000687 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.581 | 0.009434 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.590 | 0.004545 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | B.1.78 | 0.008547 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | C.35 | 0.000774 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | P.1 | 0.000016 |
| ORF1ab/nsp3 | 1241 | K1241R | aAa | aGa | 1 | 1 | P.1.1 | 0.000318 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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