CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = G251R

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3251G251RG1069RnonsynGgaAga6466320.9783283470-3472
ORF1ab/nsp3251G251RG1069RnonsynGgaCga64690.01393193470-3472
ORF1ab/nsp3251G251RG1069RnonsynGgAAgG64650.007739943470-3472

Details of the mutation G251R within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3251G251RGgaAga632646All0.000121
ORF1ab/nsp3251G251RGgaCga9646All0.000002
ORF1ab/nsp3251G251RGgAAgG5646All0.000001
ORF1ab/nsp3251G251RGgaAga8080B.1.1770.001053
ORF1ab/nsp3251G251RGgaAga7274B.1.1.70.000064
ORF1ab/nsp3251G251RGgaCga274B.1.1.70.000002
ORF1ab/nsp3251G251RGgaAga6060B.1.1.2240.857143
ORF1ab/nsp3251G251RGgaAga5353AY.40.000082
ORF1ab/nsp3251G251RGgaAga4849B.1.20.000423
ORF1ab/nsp3251G251RGgaCga149B.1.20.000009
ORF1ab/nsp3251G251RGgaAga3636AY.1030.000224
ORF1ab/nsp3251G251RGgaAga3535B.1.617.20.000132
ORF1ab/nsp3251G251RGgaAga3232AY.470.000995
ORF1ab/nsp3251G251RGgaAga1616AY.650.008529
ORF1ab/nsp3251G251RGgaAga1212P.10.000189
ORF1ab/nsp3251G251RGgaAga1010B.1.1.3170.004117
ORF1ab/nsp3251G251RGgaAga99AY.250.000054
ORF1ab/nsp3251G251RGgaAga89B.10.000073
ORF1ab/nsp3251G251RGgaCga19B.10.000009
ORF1ab/nsp3251G251RGgaAga89B.1.10.000145
ORF1ab/nsp3251G251RGgaCga19B.1.10.000018
ORF1ab/nsp3251G251RGgaAga88B.1.4000.003432
ORF1ab/nsp3251G251RGgaAga77AY.290.00011
ORF1ab/nsp3251G251RGgaAga67B.1.2210.000426
ORF1ab/nsp3251G251RGgAAgG17B.1.2210.000071
ORF1ab/nsp3251G251RGgAAgG360.166667
ORF1ab/nsp3251G251RGgaAga360.166667
ORF1ab/nsp3251G251RGgaAga66AY.330.000401
ORF1ab/nsp3251G251RGgaAga66AY.430.000027
ORF1ab/nsp3251G251RGgaAga66AY.440.000037
ORF1ab/nsp3251G251RGgaAga66B.1.5960.000523
ORF1ab/nsp3251G251RGgaAga55AY.30.00005
ORF1ab/nsp3251G251RGgaAga55B.1.2430.000348
ORF1ab/nsp3251G251RGgaAga55B.1.5260.000118
ORF1ab/nsp3251G251RGgaAga45Q.80.00066
ORF1ab/nsp3251G251RGgAAgG15Q.80.000165
ORF1ab/nsp3251G251RGgaAga44AY.340.000388
ORF1ab/nsp3251G251RGgaAga44AY.4.20.000087
ORF1ab/nsp3251G251RGgaAga44B.1.1.5190.000159
ORF1ab/nsp3251G251RGgaAga44R.10.00036
ORF1ab/nsp3251G251RGgaAga33AY.390.000074
ORF1ab/nsp3251G251RGgaAga33AY.50.000062
ORF1ab/nsp3251G251RGgaAga33AY.75.10.000541
ORF1ab/nsp3251G251RGgaAga33AY.90.000203
ORF1ab/nsp3251G251RGgaAga33AY.99.10.004658
ORF1ab/nsp3251G251RGgaAga23B.1.258.170.000208
ORF1ab/nsp3251G251RGgaCga13B.1.258.170.000104
ORF1ab/nsp3251G251RGgaAga33B.1.258.20.013514
ORF1ab/nsp3251G251RGgaAga33B.1.3510.000089
ORF1ab/nsp3251G251RGgaAga22AY.1100.000225
ORF1ab/nsp3251G251RGgaAga22AY.1130.000285
ORF1ab/nsp3251G251RGgaAga22AY.200.000078
ORF1ab/nsp3251G251RGgaAga22AY.590.001059
ORF1ab/nsp3251G251RGgaAga22AY.730.001331
ORF1ab/nsp3251G251RGgaAga22B.1.1.1590.009346
ORF1ab/nsp3251G251RGgaAga22B.1.4290.000047
ORF1ab/nsp3251G251RGgaAga22B.1.5250.000226
ORF1ab/nsp3251G251RGgaAga11AY.1020.000027
ORF1ab/nsp3251G251RGgaAga11AY.1180.000063
ORF1ab/nsp3251G251RGgaAga11AY.230.00007
ORF1ab/nsp3251G251RGgaAga11AY.260.000028
ORF1ab/nsp3251G251RGgaAga11AY.350.000233
ORF1ab/nsp3251G251RGgaAga11AY.380.000499
ORF1ab/nsp3251G251RGgaAga11AY.39.10.00004
ORF1ab/nsp3251G251RGgaAga11AY.450.000122
ORF1ab/nsp3251G251RGgaAga11AY.46.60.000072
ORF1ab/nsp3251G251RGgaAga11AY.480.000465
ORF1ab/nsp3251G251RGgaAga11AY.5.40.000277
ORF1ab/nsp3251G251RGgaAga11AY.580.000907
ORF1ab/nsp3251G251RGgaAga11AY.780.001541
ORF1ab/nsp3251G251RGgaAga11B.1.1.1890.001513
ORF1ab/nsp3251G251RGgaAga11B.1.1.2070.001182
ORF1ab/nsp3251G251RGgaAga11B.1.1.2800.003086
ORF1ab/nsp3251G251RGgaAga11B.1.1.330.000421
ORF1ab/nsp3251G251RGgaAga11B.1.1.370.000193
ORF1ab/nsp3251G251RGgaAga11B.1.1260.001276
ORF1ab/nsp3251G251RGgaAga11B.1.1600.000031
ORF1ab/nsp3251G251RGgaAga11B.1.177.820.000477
ORF1ab/nsp3251G251RGgaAga11B.1.2580.000067
ORF1ab/nsp3251G251RGgaAga11B.1.360.000146
ORF1ab/nsp3251G251RGgaAga11B.1.36.10.00114
ORF1ab/nsp3251G251RGgaCga11B.1.4270.00005
ORF1ab/nsp3251G251RGgaAga11B.1.438.10.000107
ORF1ab/nsp3251G251RGgaAga11B.1.4650.003802
ORF1ab/nsp3251G251RGgaCga11B.1.466.20.000391
ORF1ab/nsp3251G251RGgaAga11B.1.5540.004405
ORF1ab/nsp3251G251RGgaCga11B.1.5610.000397
ORF1ab/nsp3251G251RGgaAga11B.1.617.10.000129
ORF1ab/nsp3251G251RGgaAga11C.370.000116
ORF1ab/nsp3251G251RGgaAga11P.1.140.000048
ORF1ab/nsp3251G251RGgaAga11P.1.150.000232

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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