CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = E81D

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp381E81DE899DnonsyngaGgaT4324290.9930562960-2962
ORF1ab/nsp381E81DE899DnonsyngaGgaC43230.006944442960-2962

Details of the mutation E81D within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp381E81DgaGgaT429432All0.000082
ORF1ab/nsp381E81DgaGgaC3432All0.000001
ORF1ab/nsp381E81DgaGgaT109110B.1.1.70.000098
ORF1ab/nsp381E81DgaGgaC1110B.1.1.70.000001
ORF1ab/nsp381E81DgaGgaT4042B.1.617.20.000151
ORF1ab/nsp381E81DgaGgaC242B.1.617.20.000008
ORF1ab/nsp381E81DgaGgaT3030AY.40.000047
ORF1ab/nsp381E81DgaGgaT2222B.1.177.610.956522
ORF1ab/nsp381E81DgaGgaT2121AY.150.046667
ORF1ab/nsp381E81DgaGgaT2121AY.430.000093
ORF1ab/nsp381E81DgaGgaT1616AY.750.000896
ORF1ab/nsp381E81DgaGgaT1515AY.1050.009646
ORF1ab/nsp381E81DgaGgaT1313P.10.000205
ORF1ab/nsp381E81DgaGgaT1212AY.9.10.001005
ORF1ab/nsp381E81DgaGgaT88B.1.177.150.005047
ORF1ab/nsp381E81DgaGgaT77AY.440.000043
ORF1ab/nsp381E81DgaGgaT66B.1.1.3020.012448
ORF1ab/nsp381E81DgaGgaT66B.1.3670.004754
ORF1ab/nsp381E81DgaGgaT66B.1.621.10.003035
ORF1ab/nsp381E81DgaGgaT55B.1.1770.000066
ORF1ab/nsp381E81DgaGgaT55B.1.258.170.00052
ORF1ab/nsp381E81DgaGgaT44AY.1020.000106
ORF1ab/nsp381E81DgaGgaT44AY.1030.000025
ORF1ab/nsp381E81DgaGgaT44AY.250.000024
ORF1ab/nsp381E81DgaGgaT44B.1.10.000073
ORF1ab/nsp381E81DgaGgaT44B.1.20.000035
ORF1ab/nsp381E81DgaGgaT44B.1.3690.001141
ORF1ab/nsp381E81DgaGgaT33AY.1170.000254
ORF1ab/nsp381E81DgaGgaT33AY.9.20.00011
ORF1ab/nsp381E81DgaGgaT33B.1.5260.000071
ORF1ab/nsp381E81DgaGgaT22AD.20.000438
ORF1ab/nsp381E81DgaGgaT22AY.100.00106
ORF1ab/nsp381E81DgaGgaT22AY.1190.000071
ORF1ab/nsp381E81DgaGgaT22AY.260.000057
ORF1ab/nsp381E81DgaGgaT22AY.290.000032
ORF1ab/nsp381E81DgaGgaT22AY.50.000041
ORF1ab/nsp381E81DgaGgaT22AY.980.000158
ORF1ab/nsp381E81DgaGgaT22B.1.1.2690.002706
ORF1ab/nsp381E81DgaGgaT22B.1.177.820.000955
ORF1ab/nsp381E81DgaGgaT22B.1.4250.005988
ORF1ab/nsp381E81DgaGgaT22B.1.4290.000047
ORF1ab/nsp381E81DgaGgaT22B.1.6210.000177
ORF1ab/nsp381E81DgaGgaT22D.20.00015
ORF1ab/nsp381E81DgaGgaT11AY.1140.000231
ORF1ab/nsp381E81DgaGgaT11AY.130.000161
ORF1ab/nsp381E81DgaGgaT11AY.190.00114
ORF1ab/nsp381E81DgaGgaT11AY.270.000065
ORF1ab/nsp381E81DgaGgaT11AY.30.00001
ORF1ab/nsp381E81DgaGgaT11AY.34.10.00051
ORF1ab/nsp381E81DgaGgaT11AY.380.000499
ORF1ab/nsp381E81DgaGgaT11AY.410.000294
ORF1ab/nsp381E81DgaGgaT11AY.46.20.000635
ORF1ab/nsp381E81DgaGgaT11AY.540.000095
ORF1ab/nsp381E81DgaGgaT11B.10.000009
ORF1ab/nsp381E81DgaGgaT11B.1.1.2160.00089
ORF1ab/nsp381E81DgaGgaT11B.1.1.3760.005952
ORF1ab/nsp381E81DgaGgaT11B.1.1.4640.001473
ORF1ab/nsp381E81DgaGgaT11B.1.1.470.005348
ORF1ab/nsp381E81DgaGgaT11B.1.1.500.000679
ORF1ab/nsp381E81DgaGgaT11B.1.177.210.000076
ORF1ab/nsp381E81DgaGgaT11B.1.2340.000132
ORF1ab/nsp381E81DgaGgaT11B.1.2350.002519
ORF1ab/nsp381E81DgaGgaT11B.1.2390.001221
ORF1ab/nsp381E81DgaGgaT11B.1.36.80.001
ORF1ab/nsp381E81DgaGgaT11B.1.3960.000706
ORF1ab/nsp381E81DgaGgaT11B.1.5610.000397
ORF1ab/nsp381E81DgaGgaT11B.1.617.10.000129
ORF1ab/nsp381E81DgaGgaT11B.1.9.50.005682
ORF1ab/nsp381E81DgaGgaT11P.1.170.000162
ORF1ab/nsp381E81DgaGgaT11P.30.001595
ORF1ab/nsp381E81DgaGgaT11Q.10.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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