CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = E70X

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp3	70	E70X	E888X	nonsyn	Gaa	Taa	11	9	0.818182	2927-2929
ORF1ab/nsp3	70	E70X	E888X	nonsyn	GaA	TaG	11	1	0.0909091	2927-2929
ORF1ab/nsp3	70	E70X	E888X	nonsyn	GAa	TGa	11	1	0.0909091	2927-2929

Details of the mutation E70X within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp3	70	E70X	Gaa	Taa	9	11	All	0.000002
ORF1ab/nsp3	70	E70X	GaA	TaG	1	11	All	0
ORF1ab/nsp3	70	E70X	GAa	TGa	1	11	All	0
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	2	B.1.177	0.000013
ORF1ab/nsp3	70	E70X	GAa	TGa	1	2	B.1.177	0.000013
ORF1ab/nsp3	70	E70X	Gaa	Taa	2	2	B.6	0.00182
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	AY.1	0.000396
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	AY.69	0.000187
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	B.1	0.000009
ORF1ab/nsp3	70	E70X	GaA	TaG	1	1	B.1.1	0.000018
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	B.1.1.7	0.000001
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	B.1.243	0.00007
ORF1ab/nsp3	70	E70X	Gaa	Taa	1	1	B.1.466.2	0.000391

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.