CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = D112Y
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 112 | D112Y | D930Y | nonsyn | Gat | Tat | 950 | 950 | 1 | 3053-3055 |
Details of the mutation D112Y within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 950 | 950 | All | 0.000182 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 189 | 189 | C.35 | 0.146285 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 159 | 159 | AY.4 | 0.000247 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 105 | 105 | P.1 | 0.001654 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 81 | 81 | B.1.177 | 0.001067 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 72 | 72 | B.1.1.7 | 0.000064 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 53 | 53 | B.1.617.2 | 0.0002 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 36 | 36 | B.1.2 | 0.000317 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 32 | 32 | AY.43 | 0.000142 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 18 | 18 | AY.25 | 0.000108 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 15 | 15 | B.1 | 0.000137 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 11 | 11 | AY.103 | 0.000068 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 11 | 11 | AY.39 | 0.000272 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 11 | 11 | B.1.1.434 | 0.003834 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 10 | 10 | AY.77 | 0.011274 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 7 | 7 | AY.98 | 0.000553 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 7 | 7 | B.1.160.14 | 0.014831 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 6 | 6 | B.1.1.37 | 0.001157 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 5 | 5 | AY.120 | 0.000186 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 5 | 5 | AY.44 | 0.00003 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 5 | 5 | B.1.1.316 | 0.004625 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 5 | 5 | B.1.241 | 0.004058 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | AY.106 | 0.00134 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | AY.29 | 0.000063 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | AY.4.4 | 0.001637 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | B.1.1.241 | 0.008282 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | B.1.1.297 | 0.008949 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 4 | 4 | B.1.351.2 | 0.00121 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 3 | 3 | AY.37 | 0.000948 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 3 | 3 | B.1.1.25 | 0.001706 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 3 | 3 | B.1.1.519 | 0.000119 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 3 | 3 | P.1.12 | 0.001452 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | AY.23 | 0.000139 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | AY.45 | 0.000243 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | AY.5 | 0.000041 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.1 | 0.000036 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.1.216 | 0.001781 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.36.8 | 0.002 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | B.1.617.1 | 0.000258 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 2 | 2 | R.1 | 0.00018 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | A.2.2 | 0.001689 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.121 | 0.000135 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.4.2.1 | 0.000149 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.51 | 0.000909 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.7 | 0.000196 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.78 | 0.001541 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | AZ.2 | 0.000821 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.282 | 0.011628 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.372 | 0.000689 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.1.70 | 0.000341 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.147 | 0.000756 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.177.7 | 0.000165 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36.1 | 0.00114 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36.16 | 0.001425 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36.17 | 0.000494 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.36.29 | 0.000517 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.367 | 0.000792 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.396 | 0.000706 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.399 | 0.001934 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.524 | 0.001406 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.576 | 0.000907 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | B.1.610 | 0.003546 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp3 | 112 | D112Y | Gat | Tat | 1 | 1 | Q.1 | 0.000126 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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