CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = A274V

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3274A274VA1092VnonsyngCtgTt104010390.9990383539-3541
ORF1ab/nsp3274A274VA1092VnonsyngCTgTC104010.0009615383539-3541

Details of the mutation A274V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3274A274VgCtgTt10391040All0.000199
ORF1ab/nsp3274A274VgCTgTC11040All0
ORF1ab/nsp3274A274VgCtgTt153153B.1.1.70.000137
ORF1ab/nsp3274A274VgCtgTt147147AY.40.000229
ORF1ab/nsp3274A274VgCtgTt117117AY.430.000518
ORF1ab/nsp3274A274VgCtgTt6767AY.590.035487
ORF1ab/nsp3274A274VgCtgTt4545B.10.000412
ORF1ab/nsp3274A274VgCtgTt4444B.1.3510.001308
ORF1ab/nsp3274A274VgCtgTt4242AY.200.001632
ORF1ab/nsp3274A274VgCtgTt3333B.1.617.20.000124
ORF1ab/nsp3274A274VgCtgTt2727B.1.177.810.005112
ORF1ab/nsp3274A274VgCtgTt2626B.1.1600.000811
ORF1ab/nsp3274A274VgCtgTt2424AY.1200.000892
ORF1ab/nsp3274A274VgCtgTt2424B.1.1770.000316
ORF1ab/nsp3274A274VgCtgTt2222AY.1030.000137
ORF1ab/nsp3274A274VgCtgTt2121B.1.20.000185
ORF1ab/nsp3274A274VgCtgTt1717AY.440.000103
ORF1ab/nsp3274A274VgCtgTt1717AY.470.000529
ORF1ab/nsp3274A274VgCtgTt1414B.1.10.000254
ORF1ab/nsp3274A274VgCtgTt1313AY.30.000129
ORF1ab/nsp3274A274VgCtgTt1111B.1.1.1590.051402
ORF1ab/nsp3274A274VgCtgTt1010AY.260.000283
ORF1ab/nsp3274A274VgCtgTt1010AY.39.10.000396
ORF1ab/nsp3274A274VgCtgTt88B.1.2340.001056
ORF1ab/nsp3274A274VgCtgTt88P.1.40.007812
ORF1ab/nsp3274A274VgCtgTt66AY.75.10.001082
ORF1ab/nsp3274A274VgCtgTt66AY.790.007264
ORF1ab/nsp3274A274VgCtgTt66B0.000767
ORF1ab/nsp3274A274VgCtgTt66B.1.466.20.002347
ORF1ab/nsp3274A274VgCtgTt66B.1.5260.000141
ORF1ab/nsp3274A274VgCtgTt55AY.140.00044
ORF1ab/nsp3274A274VgCtgTt55P.10.000079
ORF1ab/nsp3274A274VgCtgTt44AY.50.000083
ORF1ab/nsp3274A274VgCtgTt44AY.740.000463
ORF1ab/nsp3274A274VgCtgTt44B.1.2060.003263
ORF1ab/nsp3274A274VgCtgTt44B.1.5250.000453
ORF1ab/nsp3274A274VgCtgTt33AY.230.000209
ORF1ab/nsp3274A274VgCtgTt33AY.290.000047
ORF1ab/nsp3274A274VgCtgTt33AY.4.50.000322
ORF1ab/nsp3274A274VgCtgTt33AY.9.10.000251
ORF1ab/nsp3274A274VgCtgTt33P.1.140.000143
ORF1ab/nsp3274A274VgCtgTt22AY.1020.000053
ORF1ab/nsp3274A274VgCtgTt22AY.1190.000071
ORF1ab/nsp3274A274VgCtgTt22AY.330.000134
ORF1ab/nsp3274A274VgCtgTt22AY.420.00008
ORF1ab/nsp3274A274VgCtgTt22AY.450.000243
ORF1ab/nsp3274A274VgCtgTt22AY.460.000208
ORF1ab/nsp3274A274VgCtgTt22AY.540.000191
ORF1ab/nsp3274A274VgCtgTt22B.1.1.2650.006309
ORF1ab/nsp3274A274VgCtgTt22B.1.1.5190.000079
ORF1ab/nsp3274A274VgCtgTt22B.1.1.700.000682
ORF1ab/nsp3274A274VgCtgTt12B.1.360.000146
ORF1ab/nsp3274A274VgCTgTC12B.1.360.000146
ORF1ab/nsp3274A274VgCtgTt22B.1.5640.000852
ORF1ab/nsp3274A274VgCtgTt22B.1.6090.000959
ORF1ab/nsp3274A274VgCtgTt11A.2.20.001689
ORF1ab/nsp3274A274VgCtgTt11AY.1000.000046
ORF1ab/nsp3274A274VgCtgTt11AY.1060.000335
ORF1ab/nsp3274A274VgCtgTt11AY.1150.005208
ORF1ab/nsp3274A274VgCtgTt11AY.130.000161
ORF1ab/nsp3274A274VgCtgTt11AY.16.10.00047
ORF1ab/nsp3274A274VgCtgTt11AY.250.000006
ORF1ab/nsp3274A274VgCtgTt11AY.4.20.000022
ORF1ab/nsp3274A274VgCtgTt11AY.610.000105
ORF1ab/nsp3274A274VgCtgTt11AY.620.000436
ORF1ab/nsp3274A274VgCtgTt11AY.630.000387
ORF1ab/nsp3274A274VgCtgTt11AY.670.000464
ORF1ab/nsp3274A274VgCtgTt11AY.700.000209
ORF1ab/nsp3274A274VgCtgTt11AY.760.004831
ORF1ab/nsp3274A274VgCtgTt11AY.930.000273
ORF1ab/nsp3274A274VgCtgTt11AY.960.002075
ORF1ab/nsp3274A274VgCtgTt11AY.980.000079
ORF1ab/nsp3274A274VgCtgTt11AY.98.10.000048
ORF1ab/nsp3274A274VgCtgTt11AY.99.20.000092
ORF1ab/nsp3274A274VgCtgTt11B.1.1.2290.005747
ORF1ab/nsp3274A274VgCtgTt11B.1.1.260.005236
ORF1ab/nsp3274A274VgCtgTt11B.1.1.2800.003086
ORF1ab/nsp3274A274VgCtgTt11B.1.1.2840.000107
ORF1ab/nsp3274A274VgCtgTt11B.1.1.3480.000796
ORF1ab/nsp3274A274VgCtgTt11B.1.1.3680.003086
ORF1ab/nsp3274A274VgCtgTt11B.1.1.3690.000446
ORF1ab/nsp3274A274VgCtgTt11B.1.1.4320.001266
ORF1ab/nsp3274A274VgCtgTt11B.1.1.4340.000349
ORF1ab/nsp3274A274VgCtgTt11B.1.1.950.019608
ORF1ab/nsp3274A274VgCtgTt11B.1.1570.002985
ORF1ab/nsp3274A274VgCtgTt11B.1.177.860.000183
ORF1ab/nsp3274A274VgCtgTt11B.1.2400.000216
ORF1ab/nsp3274A274VgCtgTt11B.1.3240.001605
ORF1ab/nsp3274A274VgCtgTt11B.1.351.10.038462
ORF1ab/nsp3274A274VgCtgTt11B.1.3960.000706
ORF1ab/nsp3274A274VgCtgTt11B.1.4280.00102
ORF1ab/nsp3274A274VgCtgTt11B.1.4560.003268
ORF1ab/nsp3274A274VgCtgTt11B.1.5240.001406
ORF1ab/nsp3274A274VgCtgTt11B.1.5950.000261
ORF1ab/nsp3274A274VgCtgTt11B.1.617.10.000129
ORF1ab/nsp3274A274VgCtgTt11B.1.6360.006711
ORF1ab/nsp3274A274VgCtgTt11B.400.000364
ORF1ab/nsp3274A274VgCtgTt11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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