CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = A274A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3274A274AA1092AsyngcTgcG7023470.4943023539-3541
ORF1ab/nsp3274A274AA1092AsyngcTgcC7023300.4700853539-3541
ORF1ab/nsp3274A274AA1092AsyngcTgcA702250.03561253539-3541

Details of the mutation A274A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3274A274AgcTgcG347702All0.000066
ORF1ab/nsp3274A274AgcTgcC330702All0.000063
ORF1ab/nsp3274A274AgcTgcA25702All0.000005
ORF1ab/nsp3274A274AgcTgcG333470B.1.1.70.000298
ORF1ab/nsp3274A274AgcTgcC134470B.1.1.70.00012
ORF1ab/nsp3274A274AgcTgcA3470B.1.1.70.000003
ORF1ab/nsp3274A274AgcTgcC4646B.1.617.20.000173
ORF1ab/nsp3274A274AgcTgcC1325AY.250.000078
ORF1ab/nsp3274A274AgcTgcA1225AY.250.000072
ORF1ab/nsp3274A274AgcTgcC2121AY.430.000093
ORF1ab/nsp3274A274AgcTgcG1219P.10.000189
ORF1ab/nsp3274A274AgcTgcC719P.10.00011
ORF1ab/nsp3274A274AgcTgcC1818AY.200.0007
ORF1ab/nsp3274A274AgcTgcC99AY.440.000055
ORF1ab/nsp3274A274AgcTgcC88AY.1030.00005
ORF1ab/nsp3274A274AgcTgcC77AY.40.000011
ORF1ab/nsp3274A274AgcTgcC55AY.30.00005
ORF1ab/nsp3274A274AgcTgcC55B.1.2430.000348
ORF1ab/nsp3274A274AgcTgcA44B.1.3510.000119
ORF1ab/nsp3274A274AgcTgcC44B.1.4290.000094
ORF1ab/nsp3274A274AgcTgcC33AY.230.000209
ORF1ab/nsp3274A274AgcTgcC33AY.390.000074
ORF1ab/nsp3274A274AgcTgcC33AY.50.000062
ORF1ab/nsp3274A274AgcTgcC33AY.99.20.000276
ORF1ab/nsp3274A274AgcTgcC33B.10.000027
ORF1ab/nsp3274A274AgcTgcC33B.1.2790.001541
ORF1ab/nsp3274A274AgcTgcC33B.1.6210.000266
ORF1ab/nsp3274A274AgcTgcC22AY.1020.000053
ORF1ab/nsp3274A274AgcTgcA22AY.330.000134
ORF1ab/nsp3274A274AgcTgcA12B.1.10.000018
ORF1ab/nsp3274A274AgcTgcC12B.1.10.000018
ORF1ab/nsp3274A274AgcTgcC22B.1.438.10.000215
ORF1ab/nsp3274A274AgcTgcC11AY.10.000396
ORF1ab/nsp3274A274AgcTgcC11AY.1170.000085
ORF1ab/nsp3274A274AgcTgcC11AY.16.10.00047
ORF1ab/nsp3274A274AgcTgcC11AY.260.000028
ORF1ab/nsp3274A274AgcTgcC11AY.4.20.000022
ORF1ab/nsp3274A274AgcTgcC11AY.4.40.000409
ORF1ab/nsp3274A274AgcTgcC11AY.4.50.000107
ORF1ab/nsp3274A274AgcTgcC11AY.400.000964
ORF1ab/nsp3274A274AgcTgcC11AY.460.000104
ORF1ab/nsp3274A274AgcTgcC11AY.46.60.000072
ORF1ab/nsp3274A274AgcTgcC11AY.470.000031
ORF1ab/nsp3274A274AgcTgcC11AY.580.000907
ORF1ab/nsp3274A274AgcTgcC11AY.690.000187
ORF1ab/nsp3274A274AgcTgcC11AY.9.10.000084
ORF1ab/nsp3274A274AgcTgcC11AY.920.000287
ORF1ab/nsp3274A274AgcTgcC11AY.98.10.000048
ORF1ab/nsp3274A274AgcTgcA11B.1.1.280.000311
ORF1ab/nsp3274A274AgcTgcC11B.1.1.5190.00004
ORF1ab/nsp3274A274AgcTgcC11B.1.1260.001276
ORF1ab/nsp3274A274AgcTgcC11B.1.1600.000031
ORF1ab/nsp3274A274AgcTgcC11B.1.1770.000013
ORF1ab/nsp3274A274AgcTgcC11B.1.177.730.000566
ORF1ab/nsp3274A274AgcTgcA11B.1.177.90.001332
ORF1ab/nsp3274A274AgcTgcC11B.1.3440.008197
ORF1ab/nsp3274A274AgcTgcA11B.1.351.30.000876
ORF1ab/nsp3274A274AgcTgcG11B.1.4620.007246
ORF1ab/nsp3274A274AgcTgcC11B.1.5170.000427
ORF1ab/nsp3274A274AgcTgcG11B.1.6090.000479
ORF1ab/nsp3274A274AgcTgcC11B.550.00295
ORF1ab/nsp3274A274AgcTgcC11D.20.000075
ORF1ab/nsp3274A274AgcTgcC11P.1.100.000269
ORF1ab/nsp3274A274AgcTgcC11P.70.004367

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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