CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : Mut = A256V
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp3 | 256 | A256V | A1074V | nonsyn | gCc | gTc | 3370 | 3370 | 1 | 3485-3487 |
Details of the mutation A256V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3370 | 3370 | All | 0.000645 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1490 | 1490 | B.1.2 | 0.01312 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 727 | 727 | AY.11 | 0.973226 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 188 | 188 | AY.4 | 0.000293 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 144 | 144 | B.1.1.7 | 0.000129 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 91 | 91 | B.1.177.86 | 0.016694 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 65 | 65 | B.1.1.130 | 1 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 62 | 62 | AY.7 | 0.012152 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 44 | 44 | AY.44 | 0.000268 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 44 | 44 | B.1.621 | 0.003895 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 31 | 31 | AY.25 | 0.000186 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 31 | 31 | B.1.596 | 0.002701 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 28 | 28 | B.1 | 0.000256 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 24 | 24 | P.1 | 0.000378 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 23 | 23 | AY.26 | 0.000651 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 22 | 22 | C.37 | 0.002553 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 21 | 21 | B.1.617.2 | 0.000079 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 19 | 19 | AY.43 | 0.000084 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 19 | 19 | AY.5 | 0.000392 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 18 | 18 | B.1.340 | 0.077253 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 16 | 16 | AY.3 | 0.000159 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 15 | 15 | AY.33 | 0.001002 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 15 | 15 | AY.9 | 0.001014 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 15 | 15 | B.1.1 | 0.000272 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 14 | 14 | B.1.177 | 0.000184 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 14 | 14 | P.2 | 0.002613 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 12 | 12 | AY.39 | 0.000297 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 10 | 10 | B.1.588 | 0.009099 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 8 | 8 | AY.47 | 0.000249 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 7 | 7 | AY.103 | 0.000043 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 7 | 7 | B.1.1.420 | 0.007042 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 6 | 6 | AY.118 | 0.000376 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 5 | 5 | B.1.36 | 0.00073 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | AY.12 | 0.001264 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | AY.29 | 0.000063 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | AY.4.2 | 0.000087 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | B.1.110.3 | 0.002874 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | B.1.241 | 0.003247 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | B.1.351 | 0.000119 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | B.1.427 | 0.000202 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 4 | 4 | P.1.14 | 0.000191 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | AY.113 | 0.000427 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | AY.13 | 0.000483 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | AY.27 | 0.000194 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | AY.40 | 0.002893 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | AY.75 | 0.000168 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | B.1.1.174 | 0.010135 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | B.1.160 | 0.000094 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | B.1.240 | 0.000647 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | B.1.306 | 0.017143 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | B.10 | 0.024793 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 3 | 3 | P.1.1 | 0.000953 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | A.2.5.2 | 0.003145 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | AY.42 | 0.00008 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | AY.75.1 | 0.000361 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | B.1.1.222 | 0.000408 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | B.1.177.21 | 0.000153 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | B.1.177.58 | 0.002663 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | B.1.221 | 0.000142 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | B.1.36.8 | 0.002 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | P.1.7 | 0.000639 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 2 | 2 | R.1 | 0.00018 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | A.3 | 0.002096 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.16 | 0.00038 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.37 | 0.000316 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.4.4 | 0.000409 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.46.5 | 0.000198 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.54 | 0.000095 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.55 | 0.000917 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.58 | 0.000907 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.7.1 | 0.000113 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.79 | 0.001211 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.80 | 0.001129 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | AY.9.1 | 0.000084 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.1.189 | 0.001513 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.1.462 | 0.008621 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.1.70 | 0.000341 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.160.16 | 0.000929 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.177.46 | 0.000918 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.177.6 | 0.000977 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.177.73 | 0.000566 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.239 | 0.001221 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.36.16 | 0.001425 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.36.29 | 0.000517 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.429 | 0.000024 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.456 | 0.003268 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.470 | 0.001404 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.471 | 0.002732 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.560 | 0.00463 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.575 | 0.000303 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.606 | 0.006024 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | B.1.8 | 0.001972 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | P.1.15 | 0.000232 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | Q.1 | 0.000126 |
| ORF1ab/nsp3 | 256 | A256V | gCc | gTc | 1 | 1 | Q.2 | 0.000613 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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