CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 977 & Codon = Caa

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp3	977	K977Q	K1795Q	nonsyn	Aaa	Caa	115003	115002	0.999991	5648-5650

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp3	977	K977Q	Aaa	Caa	115002	115003	All	0.021995
ORF1ab/nsp3	977	K977Q	Aaa	Caa	63187	63187	P.1	0.995447
ORF1ab/nsp3	977	K977Q	Aaa	Caa	20812	20812	P.1.14	0.994837
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6167	6167	P.1.17	0.997574
ORF1ab/nsp3	977	K977Q	Aaa	Caa	4275	4275	P.1.15	0.993262
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3702	3702	P.1.10	0.997575
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3123	3123	P.1.7	0.997126
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3014	3014	P.1.1	0.957433
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2631	2631	P.1.16	0.984287
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1959	1959	P.1.12	0.948209
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1100	1100	P.1.13	0.98832
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1028	1028	P.1.17.1	0.899388
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1024	1024	P.1.4	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	862	862	P.1.2	0.996532
ORF1ab/nsp3	977	K977Q	Aaa	Caa	514	514	P.1.6	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	209	209	P.1.8	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	208	208	P.1.9	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	188	188	B.1.630	0.984293
ORF1ab/nsp3	977	K977Q	Aaa	Caa	152	152	B.1.1.7	0.000136
ORF1ab/nsp3	977	K977Q	Aaa	Caa	121	122	B.1	0.001108
ORF1ab/nsp3	977	K977Q	Aaa	Caa	114	114	P.1.10.1	0.926829
ORF1ab/nsp3	977	K977Q	Aaa	Caa	98	98	P.1.11	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	82	82	B.1.1	0.001488
ORF1ab/nsp3	977	K977Q	Aaa	Caa	72	72	AY.9.2	0.002645
ORF1ab/nsp3	977	K977Q	Aaa	Caa	45	45	B.1.241	0.036526
ORF1ab/nsp3	977	K977Q	Aaa	Caa	29	29	C.37	0.003366
ORF1ab/nsp3	977	K977Q	Aaa	Caa	29	29	P.1.3	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	24	24	P.1.10.2	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	21	21	B.1.1.528	0.100962
ORF1ab/nsp3	977	K977Q	Aaa	Caa	16	16	B.1.617.2	0.00006
ORF1ab/nsp3	977	K977Q	Aaa	Caa	13	13	P.1.5	1
ORF1ab/nsp3	977	K977Q	Aaa	Caa	10	10	A.2.5	0.00499
ORF1ab/nsp3	977	K977Q	Aaa	Caa	9	9	B.1.1.28	0.002801
ORF1ab/nsp3	977	K977Q	Aaa	Caa	8	8	AY.26	0.000226
ORF1ab/nsp3	977	K977Q	Aaa	Caa	8	8	C.37.1	0.020942
ORF1ab/nsp3	977	K977Q	Aaa	Caa	7	7	AY.43	0.000031
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6	6	AY.25	0.000036
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6	6	AY.4	0.000009
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6	6	AY.44	0.000037
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6	6	B.1.177	0.000079
ORF1ab/nsp3	977	K977Q	Aaa	Caa	6	6	B.1.416	0.007614
ORF1ab/nsp3	977	K977Q	Aaa	Caa	5	5	B.1.429	0.000118
ORF1ab/nsp3	977	K977Q	Aaa	Caa	5	5	B.1.526	0.000118
ORF1ab/nsp3	977	K977Q	Aaa	Caa	5	5	B.1.621	0.000443
ORF1ab/nsp3	977	K977Q	Aaa	Caa	4	4	B	0.000511
ORF1ab/nsp3	977	K977Q	Aaa	Caa	4	4	B.1.1.507	0.034783
ORF1ab/nsp3	977	K977Q	Aaa	Caa	4	4	B.1.637	0.000292
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	AY.23	0.000209
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	AY.61	0.000314
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	AY.75.1	0.000541
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	AY.99.2	0.000276
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	B.1.1.372	0.002066
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	B.1.177.7	0.000495
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	B.1.2	0.000026
ORF1ab/nsp3	977	K977Q	Aaa	Caa	3	3	B.1.596	0.000261
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	AY.3	0.00002
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	AY.39	0.000049
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	AY.47	0.000062
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	AY.62	0.000871
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.1.220	0.003717
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.1.409	0.005666
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.1.519	0.000079
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.1.54	0.006042
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.177.73	0.001133
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.311	0.000549
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.349	0.00143
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.623	0.001073
ORF1ab/nsp3	977	K977Q	Aaa	Caa	2	2	B.1.636	0.013423
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	A.2.2	0.001689
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.100	0.000046
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.102	0.000027
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.103	0.000006
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.119	0.000035
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.120.2	0.001285
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.2	0.000356
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.34	0.000097
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.42	0.00004
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.45	0.000122
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.46.6	0.000072
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.71	0.000475
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.74	0.000116
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.75	0.000056
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	AY.84	0.000437
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.1.121	0.002427
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.1.198	0.001468
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.1.241	0.00207
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.170	0.00431
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.177.86	0.000183
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.179	0.003759
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.214	0.003663
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.221	0.000071
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.332	0.003497
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.351	0.00003
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.369	0.000285
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.375	0.00082
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.415	0.014286
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.503	0.002488
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.533	0.009615
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.582	0.000491
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.620	0.000946
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	B.1.93	0.000934
ORF1ab/nsp3	977	K977Q	Aaa	Caa	1	1	C.35	0.000774

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.