CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 70 & Codon = gaT

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp3	70	E70D	E888D	nonsyn	gaA	gaT	86	13	0.151163	2927-2929

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp3	70	E70D	gaA	gaT	13	86	All	0.000002
ORF1ab/nsp3	70	E70D	gaA	gaT	1	12	AY.23	0.00007
ORF1ab/nsp3	70	E70D	gaA	gaT	2	6	B.1.1.7	0.000002
ORF1ab/nsp3	70	E70D	gaA	gaT	2	4		0.111111
ORF1ab/nsp3	70	E70D	gaA	gaT	1	3	AY.25	0.000006
ORF1ab/nsp3	70	E70D	gaA	gaT	1	2	AY.100	0.000046
ORF1ab/nsp3	70	E70D	gaA	gaT	1	2	AY.119	0.000035
ORF1ab/nsp3	70	E70D	gaA	gaT	1	2	AY.39	0.000025
ORF1ab/nsp3	70	E70D	gaA	gaT	2	2	P.1	0.000032
ORF1ab/nsp3	70	E70D	gaA	gaT	1	1	B.1.243	0.00007
ORF1ab/nsp3	70	E70D	gaA	gaT	1	1	D.2	0.000075

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.