CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 70 & Codon = gaC

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp3	70	E70D	E888D	nonsyn	gaA	gaC	86	73	0.848837	2927-2929

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp3	70	E70D	gaA	gaC	73	86	All	0.000014
ORF1ab/nsp3	70	E70D	gaA	gaC	11	12	AY.23	0.000767
ORF1ab/nsp3	70	E70D	gaA	gaC	10	10	AY.4	0.000016
ORF1ab/nsp3	70	E70D	gaA	gaC	7	7	B.1.1.28	0.002179
ORF1ab/nsp3	70	E70D	gaA	gaC	4	6	B.1.1.7	0.000004
ORF1ab/nsp3	70	E70D	gaA	gaC	2	4		0.111111
ORF1ab/nsp3	70	E70D	gaA	gaC	4	4	AY.20	0.000155
ORF1ab/nsp3	70	E70D	gaA	gaC	4	4	AY.66	0.004278
ORF1ab/nsp3	70	E70D	gaA	gaC	4	4	AY.7.2	0.002237
ORF1ab/nsp3	70	E70D	gaA	gaC	4	4	AY.75	0.000224
ORF1ab/nsp3	70	E70D	gaA	gaC	4	4	B.1.617.2	0.000015
ORF1ab/nsp3	70	E70D	gaA	gaC	2	3	AY.25	0.000012
ORF1ab/nsp3	70	E70D	gaA	gaC	3	3	B.1.1.434	0.001046
ORF1ab/nsp3	70	E70D	gaA	gaC	1	2	AY.100	0.000046
ORF1ab/nsp3	70	E70D	gaA	gaC	1	2	AY.119	0.000035
ORF1ab/nsp3	70	E70D	gaA	gaC	1	2	AY.39	0.000025
ORF1ab/nsp3	70	E70D	gaA	gaC	2	2	B.1.427	0.000101
ORF1ab/nsp3	70	E70D	gaA	gaC	2	2	B.1.428	0.002041
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	AY.26	0.000028
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	AY.3	0.00001
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	AY.43	0.000004
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	AY.45	0.000122
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	B.1.1.220	0.001859
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	B.1.160	0.000031
ORF1ab/nsp3	70	E70D	gaA	gaC	1	1	B.1.429	0.000024

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.