CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 545

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3545E545GE1363GnonsyngAggGg2327232714352-4354
ORF1ab/nsp3545E545EE1363EsyngaGgaA91291214352-4354
ORF1ab/nsp3545E545AE1363AnonsyngAggCg39139114352-4354
ORF1ab/nsp3545E545DE1363DnonsyngaGgaT3343260.9760484352-4354
ORF1ab/nsp3545E545DE1363DnonsyngaGgaC33480.02395214352-4354
ORF1ab/nsp3545E545KE1363KnonsynGagAag60590.9833334352-4354
ORF1ab/nsp3545E545KE1363KnonsynGaGAaA6010.01666674352-4354
ORF1ab/nsp3545E545delE1363deldelGAG---393914352-4354
ORF1ab/nsp3545E545XE1363XnonsynGagTag202014352-4354
ORF1ab/nsp3545E545VE1363VnonsyngAggTg151514352-4354
ORF1ab/nsp3545E545QE1363QnonsynGagCag6614352-4354
ORF1ab/nsp3545E545del1E1363del1delgaGga-530.64352-4354
ORF1ab/nsp3545E545del1E1363del1delGAG-NN510.24352-4354
ORF1ab/nsp3545E545del1E1363del1delgAgg-g510.24352-4354
ORF1ab/nsp3545E545del2E1363del2delgAGg--3314352-4354
ORF1ab/nsp3545E545NE1363NnonsynGaGAaT2214352-4354
ORF1ab/nsp3545E545YE1363YnonsynGaGTaT1114352-4354

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3545E545GgAggGg23272327All0.000445
ORF1ab/nsp3545E545GgAggGg22022202B.1.1.70.001971
ORF1ab/nsp3545E545EgaGgaA912912All0.000174
ORF1ab/nsp3545E545EgaGgaA567567B.1.1.3260.998239
ORF1ab/nsp3545E545AgAggCg391391All0.000075
ORF1ab/nsp3545E545DgaGgaT326334All0.000062
ORF1ab/nsp3545E545DgaGgaC8334All0.000002
ORF1ab/nsp3545E545AgAggCg156156B.1.1.70.00014
ORF1ab/nsp3545E545EgaGgaA140140B.1.1.70.000125
ORF1ab/nsp3545E545AgAggCg9898B.1.177.160.065116
ORF1ab/nsp3545E545KGagAag5960All0.000011
ORF1ab/nsp3545E545KGaGAaA160All0
ORF1ab/nsp3545E545EgaGgaA4444B.1.5370.88
ORF1ab/nsp3545E545DgaGgaT4040B.1.1110.047004
ORF1ab/nsp3545E545delGAG---3939All0.000007
ORF1ab/nsp3545E545GgAggGg3838AY.40.000059
ORF1ab/nsp3545E545AgAggCg3535AY.40.000054
ORF1ab/nsp3545E545AgAggCg3535B.1.617.20.000132
ORF1ab/nsp3545E545EgaGgaA3333AY.390.000815
ORF1ab/nsp3545E545DgaGgaT3333B.1.4740.062738
ORF1ab/nsp3545E545GgAggGg3030AY.1200.001115
ORF1ab/nsp3545E545DgaGgaT2828AY.330.00187
ORF1ab/nsp3545E545DgaGgaT2728B.1.617.20.000102
ORF1ab/nsp3545E545DgaGgaC128B.1.617.20.000004
ORF1ab/nsp3545E545EgaGgaA2727B.1.1.4340.009411
ORF1ab/nsp3545E545DgaGgaT2626B.1.4270.001313
ORF1ab/nsp3545E545DgaGgaT2222B.10.000202
ORF1ab/nsp3545E545KGagAag2222B.1.1.70.00002
ORF1ab/nsp3545E545XGagTag2020All0.000004
ORF1ab/nsp3545E545delGAG---2020B.1.1.70.000018
ORF1ab/nsp3545E545VgAggTg1515All0.000003
ORF1ab/nsp3545E545EgaGgaA1414AY.840.006124
ORF1ab/nsp3545E545KGagAag1313B.1.5260.000306
ORF1ab/nsp3545E545AgAggCg1212AY.30.000119
ORF1ab/nsp3545E545EgaGgaA1212B.1.1.80.043011
ORF1ab/nsp3545E545DgaGgaT1111B.1.1.70.00001
ORF1ab/nsp3545E545DgaGgaT1111B.1.2430.000765
ORF1ab/nsp3545E545DgaGgaT910B.1.20.000079
ORF1ab/nsp3545E545DgaGgaC110B.1.20.000009
ORF1ab/nsp3545E545EgaGgaA99B.10.000082
ORF1ab/nsp3545E545VgAggTg99B.1.2060.007341
ORF1ab/nsp3545E545DgaGgaC58AY.1020.000133
ORF1ab/nsp3545E545DgaGgaT38AY.1020.00008
ORF1ab/nsp3545E545EgaGgaA88AY.1100.000902
ORF1ab/nsp3545E545DgaGgaT88AY.40.000012
ORF1ab/nsp3545E545DgaGgaT77AY.1030.000043
ORF1ab/nsp3545E545DgaGgaT77AY.1200.00026
ORF1ab/nsp3545E545DgaGgaT77B.1.10.000127
ORF1ab/nsp3545E545EgaGgaA77B.1.177.810.001325
ORF1ab/nsp3545E545DgaGgaT77B.1.4290.000165
ORF1ab/nsp3545E545QGagCag66All0.000001
ORF1ab/nsp3545E545AgAggCg66AY.4.20.00013
ORF1ab/nsp3545E545DgaGgaT66AY.430.000027
ORF1ab/nsp3545E545KGagAag66AY.430.000027
ORF1ab/nsp3545E545DgaGgaT66AY.440.000037
ORF1ab/nsp3545E545GgAggGg66B.1.10.000109
ORF1ab/nsp3545E545GgAggGg66B.1.1770.000079
ORF1ab/nsp3545E545AgAggCg66B.1.3490.004289
ORF1ab/nsp3545E545del1gaGga-35All0.000001
ORF1ab/nsp3545E545del1GAG-NN15All0
ORF1ab/nsp3545E545del1gAgg-g15All0
ORF1ab/nsp3545E545AgAggCg55AY.250.00003
ORF1ab/nsp3545E545KGagAag55AY.30.00005
ORF1ab/nsp3545E545delGAG---55AY.40.000008
ORF1ab/nsp3545E545XGagTag55B.10.000046
ORF1ab/nsp3545E545DgaGgaT55B.1.1770.000066
ORF1ab/nsp3545E545EgaGgaA55B.1.20.000044
ORF1ab/nsp3545E545EgaGgaA44AY.40.000006
ORF1ab/nsp3545E545AgAggCg44AY.430.000018
ORF1ab/nsp3545E545AgAggCg44AY.440.000024
ORF1ab/nsp3545E545DgaGgaT44AY.540.000381
ORF1ab/nsp3545E545DgaGgaT44AY.610.000419
ORF1ab/nsp3545E545EgaGgaA44B.1.1600.000125
ORF1ab/nsp3545E545GgAggGg44B.1.177.530.009569
ORF1ab/nsp3545E545GgAggGg44B.1.3510.000119
ORF1ab/nsp3545E545DgaGgaT44B.1.4000.001716
ORF1ab/nsp3545E545GgAggGg44B.1.617.20.000015
ORF1ab/nsp3545E545GgAggGg44Q.10.000505
ORF1ab/nsp3545E545del2gAGg--33All0.000001
ORF1ab/nsp3545E545DgaGgaT33AY.1000.000138
ORF1ab/nsp3545E545EgaGgaA33AY.1030.000019
ORF1ab/nsp3545E545DgaGgaT33AY.250.000018
ORF1ab/nsp3545E545delGAG---33AY.4.50.000322
ORF1ab/nsp3545E545XGagTag33AY.430.000013
ORF1ab/nsp3545E545GgAggGg33AY.850.001282
ORF1ab/nsp3545E545DgaGgaT33AY.99.20.000276
ORF1ab/nsp3545E545AgAggCg33AY.99.20.000276
ORF1ab/nsp3545E545AgAggCg33B.10.000027
ORF1ab/nsp3545E545GgAggGg33B.1.1.5190.000119
ORF1ab/nsp3545E545AgAggCg33B.1.1770.00004
ORF1ab/nsp3545E545delGAG---33B.1.1770.00004
ORF1ab/nsp3545E545EgaGgaA33B.1.1770.00004
ORF1ab/nsp3545E545AgAggCg33B.1.177.820.001432
ORF1ab/nsp3545E545NGaGAaT22All0
ORF1ab/nsp3545E545DgaGgaT22AY.1070.000932
ORF1ab/nsp3545E545DgaGgaT22AY.160.000759
ORF1ab/nsp3545E545KGagAag22AY.230.000139
ORF1ab/nsp3545E545GgAggGg22AY.290.000032
ORF1ab/nsp3545E545DgaGgaT22AY.30.00002
ORF1ab/nsp3545E545DgaGgaT22AY.390.000049
ORF1ab/nsp3545E545GgAggGg22AY.4.20.000043
ORF1ab/nsp3545E545KGagAag22AY.440.000012
ORF1ab/nsp3545E545GgAggGg22AY.470.000062
ORF1ab/nsp3545E545DgaGgaT22AY.470.000062
ORF1ab/nsp3545E545AgAggCg22AY.610.00021
ORF1ab/nsp3545E545DgaGgaT22AY.690.000373
ORF1ab/nsp3545E545VgAggTg22AY.980.000158
ORF1ab/nsp3545E545GgAggGg22B.10.000018
ORF1ab/nsp3545E545EgaGgaA22B.1.10.000036
ORF1ab/nsp3545E545DgaGgaT22B.1.1.3180.000604
ORF1ab/nsp3545E545GgAggGg22B.1.20.000018
ORF1ab/nsp3545E545EgaGgaA22B.1.214.20.001199
ORF1ab/nsp3545E545AgAggCg22B.1.2360.004107
ORF1ab/nsp3545E545QGagCag22B.1.2580.000133
ORF1ab/nsp3545E545AgAggCg22B.1.3510.000059
ORF1ab/nsp3545E545delGAG---22B.1.617.20.000008
ORF1ab/nsp3545E545KGagAag22B.1.617.20.000008
ORF1ab/nsp3545E545EgaGgaA22B.1.617.20.000008
ORF1ab/nsp3545E545AgAggCg22C.110.021277
ORF1ab/nsp3545E545EgaGgaA22P.1.140.000096
ORF1ab/nsp3545E545DgaGgaT22P.20.000373
ORF1ab/nsp3545E545del1GAG-NN110.055556
ORF1ab/nsp3545E545XGagTag11A0.000387
ORF1ab/nsp3545E545EgaGgaA11A.2.50.000499
ORF1ab/nsp3545E545YGaGTaT11All0
ORF1ab/nsp3545E545EgaGgaA11AY.1010.00049
ORF1ab/nsp3545E545delGAG---11AY.1030.000006
ORF1ab/nsp3545E545GgAggGg11AY.1030.000006
ORF1ab/nsp3545E545delGAG---11AY.1110.000183
ORF1ab/nsp3545E545EgaGgaA11AY.1130.000142
ORF1ab/nsp3545E545DgaGgaT11AY.1170.000085
ORF1ab/nsp3545E545DgaGgaT11AY.1180.000063
ORF1ab/nsp3545E545GgAggGg11AY.1190.000035
ORF1ab/nsp3545E545DgaGgaT11AY.16.10.00047
ORF1ab/nsp3545E545GgAggGg11AY.200.000039
ORF1ab/nsp3545E545DgaGgaT11AY.200.000039
ORF1ab/nsp3545E545EgaGgaA11AY.250.000006
ORF1ab/nsp3545E545QGagCag11AY.250.000006
ORF1ab/nsp3545E545XGagTag11AY.250.000006
ORF1ab/nsp3545E545EgaGgaA11AY.260.000028
ORF1ab/nsp3545E545AgAggCg11AY.260.000028
ORF1ab/nsp3545E545GgAggGg11AY.260.000028
ORF1ab/nsp3545E545DgaGgaT11AY.270.000065
ORF1ab/nsp3545E545EgaGgaA11AY.290.000016
ORF1ab/nsp3545E545EgaGgaA11AY.30.00001
ORF1ab/nsp3545E545QGagCag11AY.30.00001
ORF1ab/nsp3545E545NGaGAaT11AY.3.10.000085
ORF1ab/nsp3545E545AgAggCg11AY.340.000097
ORF1ab/nsp3545E545GgAggGg11AY.390.000025
ORF1ab/nsp3545E545AgAggCg11AY.39.10.00004
ORF1ab/nsp3545E545del2gAGg--11AY.40.000002
ORF1ab/nsp3545E545KGagAag11AY.4.20.000022
ORF1ab/nsp3545E545DgaGgaT11AY.4.20.000022
ORF1ab/nsp3545E545DgaGgaT11AY.400.000964
ORF1ab/nsp3545E545YGaGTaT11AY.430.000004
ORF1ab/nsp3545E545EgaGgaA11AY.440.000006
ORF1ab/nsp3545E545XGagTag11AY.440.000006
ORF1ab/nsp3545E545del1gAgg-g11AY.450.000122
ORF1ab/nsp3545E545DgaGgaT11AY.50.000021
ORF1ab/nsp3545E545XGagTag11AY.520.000814
ORF1ab/nsp3545E545DgaGgaT11AY.550.000917
ORF1ab/nsp3545E545GgAggGg11AY.60.000041
ORF1ab/nsp3545E545GgAggGg11AY.610.000105
ORF1ab/nsp3545E545DgaGgaT11AY.7.10.000113
ORF1ab/nsp3545E545XGagTag11AY.750.000056
ORF1ab/nsp3545E545EgaGgaA11AY.750.000056
ORF1ab/nsp3545E545AgAggCg11AY.840.000437
ORF1ab/nsp3545E545DgaGgaT11AY.9.2.10.001976
ORF1ab/nsp3545E545AgAggCg11AY.98.10.000048
ORF1ab/nsp3545E545DgaGgaT11AY.990.001049
ORF1ab/nsp3545E545XGagTag11B0.000128
ORF1ab/nsp3545E545DgaGgaT11B0.000128
ORF1ab/nsp3545E545XGagTag11B.1.10.000018
ORF1ab/nsp3545E545VgAggTg11B.1.10.000018
ORF1ab/nsp3545E545AgAggCg11B.1.10.000018
ORF1ab/nsp3545E545DgaGgaT11B.1.1.2220.000204
ORF1ab/nsp3545E545KGagAag11B.1.1.2530.002506
ORF1ab/nsp3545E545XGagTag11B.1.1.2580.003257
ORF1ab/nsp3545E545KGagAag11B.1.1.2970.002237
ORF1ab/nsp3545E545EgaGgaA11B.1.1.3060.000438
ORF1ab/nsp3545E545del2gAGg--11B.1.1.3110.000358
ORF1ab/nsp3545E545EgaGgaA11B.1.1.3180.000302
ORF1ab/nsp3545E545EgaGgaA11B.1.1.3400.045455
ORF1ab/nsp3545E545DgaGgaT11B.1.1.3480.000796
ORF1ab/nsp3545E545DgaGgaC11B.1.1.3770.001381
ORF1ab/nsp3545E545GgAggGg11B.1.1.3780.007299
ORF1ab/nsp3545E545DgaGgaT11B.1.1.3890.006061
ORF1ab/nsp3545E545XGagTag11B.1.1.4020.011111
ORF1ab/nsp3545E545XGagTag11B.1.1.4090.002833
ORF1ab/nsp3545E545EgaGgaA11B.1.1.4160.000905
ORF1ab/nsp3545E545delGAG---11B.1.1.5190.00004
ORF1ab/nsp3545E545DgaGgaT11B.1.1.5190.00004
ORF1ab/nsp3545E545QGagCag11B.1.1.70.000001
ORF1ab/nsp3545E545del2gAGg--11B.1.1.70.000001
ORF1ab/nsp3545E545delGAG---11B.1.1600.000031
ORF1ab/nsp3545E545KGagAag11B.1.1770.000013
ORF1ab/nsp3545E545del1gaGga-11B.1.1770.000013
ORF1ab/nsp3545E545EgaGgaA11B.1.177.160.000664
ORF1ab/nsp3545E545DgaGgaT11B.1.177.600.000218
ORF1ab/nsp3545E545del1gaGga-11B.1.177.630.002703
ORF1ab/nsp3545E545del1gaGga-11B.1.20.000009
ORF1ab/nsp3545E545KGagAag11B.1.20.000009
ORF1ab/nsp3545E545AgAggCg11B.1.20.000009
ORF1ab/nsp3545E545GgAggGg11B.1.258.170.000104
ORF1ab/nsp3545E545XGagTag11B.1.3010.005917
ORF1ab/nsp3545E545VgAggTg11B.1.3380.008621
ORF1ab/nsp3545E545delGAG---11B.1.360.000146
ORF1ab/nsp3545E545DgaGgaT11B.1.36.180.00042
ORF1ab/nsp3545E545EgaGgaA11B.1.36.80.001
ORF1ab/nsp3545E545delGAG---11B.1.4150.014286
ORF1ab/nsp3545E545AgAggCg11B.1.438.10.000107
ORF1ab/nsp3545E545AgAggCg11B.1.5260.000024
ORF1ab/nsp3545E545NGaGAaT11B.1.5260.000024
ORF1ab/nsp3545E545EgaGgaA11B.1.5260.000024
ORF1ab/nsp3545E545DgaGgaT11B.1.5330.009615
ORF1ab/nsp3545E545EgaGgaA11B.1.5640.000426
ORF1ab/nsp3545E545EgaGgaA11B.1.5960.000087
ORF1ab/nsp3545E545DgaGgaT11B.1.617.10.000129
ORF1ab/nsp3545E545KGaGAaA11B.1.617.10.000129
ORF1ab/nsp3545E545VgAggTg11B.1.6210.000089
ORF1ab/nsp3545E545EgaGgaA11B.1.6210.000089
ORF1ab/nsp3545E545XGagTag11B.1.6230.000536
ORF1ab/nsp3545E545DgaGgaT11B.1.6230.000536
ORF1ab/nsp3545E545GgAggGg11B.1.6370.000073
ORF1ab/nsp3545E545GgAggGg11B.120.00641
ORF1ab/nsp3545E545DgaGgaT11B.550.00295
ORF1ab/nsp3545E545AgAggCg11B.60.00091
ORF1ab/nsp3545E545EgaGgaA11C.140.004329
ORF1ab/nsp3545E545VgAggTg11C.360.000911
ORF1ab/nsp3545E545DgaGgaT11C.36.30.000567
ORF1ab/nsp3545E545QGagCag11D.20.000075
ORF1ab/nsp3545E545EgaGgaA11N.50.001767
ORF1ab/nsp3545E545KGagAag11P.10.000016
ORF1ab/nsp3545E545DgaGgaT11P.10.000016
ORF1ab/nsp3545E545EgaGgaA11P.10.000016
ORF1ab/nsp3545E545KGagAag11P.1.140.000048
ORF1ab/nsp3545E545EgaGgaA11P.1.150.000232
ORF1ab/nsp3545E545EgaGgaA11P.20.000187
ORF1ab/nsp3545E545DgaGgaT11Q.40.000455
ORF1ab/nsp3545E545GgAggGg11Q.70.001111
ORF1ab/nsp3545E545GgAggGg11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.