CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 497

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3497K497KK1315KsynaaAaaG44444414208-4210
ORF1ab/nsp3497K497RK1315RnonsynaAaaGa2092080.9952154208-4210
ORF1ab/nsp3497K497RK1315RnonsynaAAaGG20910.004784694208-4210
ORF1ab/nsp3497K497TK1315TnonsynaAaaCa1371350.9854014208-4210
ORF1ab/nsp3497K497TK1315TnonsynaAAaCC13720.01459854208-4210
ORF1ab/nsp3497K497QK1315QnonsynAaaCaa484814208-4210
ORF1ab/nsp3497K497IK1315InonsynaAaaTa313114208-4210
ORF1ab/nsp3497K497EK1315EnonsynAaaGaa313114208-4210
ORF1ab/nsp3497K497delK1315deldelAAA---242414208-4210
ORF1ab/nsp3497K497NK1315NnonsynaaAaaC22140.6363644208-4210
ORF1ab/nsp3497K497NK1315NnonsynaaAaaT2280.3636364208-4210
ORF1ab/nsp3497K497del1K1315del1delAaa-aa6614208-4210
ORF1ab/nsp3497K497SK1315SnonsynaAAaGC3314208-4210
ORF1ab/nsp3497K497del2K1315del2delAAa--a2214208-4210
ORF1ab/nsp3497K497MK1315MnonsynaAAaTG1114208-4210
ORF1ab/nsp3497K497LK1315LnonsynAAaCTa1114208-4210
ORF1ab/nsp3497K497XK1315XnonsynAaaTaa1114208-4210

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3497K497KaaAaaG444444All0.000085
ORF1ab/nsp3497K497KaaAaaG279279AY.290.004401
ORF1ab/nsp3497K497RaAaaGa208209All0.00004
ORF1ab/nsp3497K497RaAAaGG1209All0
ORF1ab/nsp3497K497TaAaaCa135137All0.000026
ORF1ab/nsp3497K497TaAAaCC2137All0
ORF1ab/nsp3497K497RaAaaGa9696B.1.1.70.000086
ORF1ab/nsp3497K497TaAaaCa7575B.1.1.70.000067
ORF1ab/nsp3497K497QAaaCaa4848All0.000009
ORF1ab/nsp3497K497EAaaGaa3131All0.000006
ORF1ab/nsp3497K497IaAaaTa3131All0.000006
ORF1ab/nsp3497K497TaAaaCa2828B.10.000256
ORF1ab/nsp3497K497IaAaaTa2626B.1.1.70.000023
ORF1ab/nsp3497K497KaaAaaG2525AY.200.000972
ORF1ab/nsp3497K497KaaAaaG2525B.1.1.70.000022
ORF1ab/nsp3497K497delAAA---2424All0.000005
ORF1ab/nsp3497K497NaaAaaC1422All0.000003
ORF1ab/nsp3497K497NaaAaaT822All0.000002
ORF1ab/nsp3497K497QAaaCaa1717B.1.1.70.000015
ORF1ab/nsp3497K497TaAaaCa1717B.1.4290.0004
ORF1ab/nsp3497K497QAaaCaa1616B.1.1.130.571429
ORF1ab/nsp3497K497KaaAaaG1515AY.40.000023
ORF1ab/nsp3497K497EAaaGaa1515B.1.1.70.000013
ORF1ab/nsp3497K497RaAaaGa1010AY.1200.000372
ORF1ab/nsp3497K497RaAaaGa1010AY.290.000158
ORF1ab/nsp3497K497RaAaaGa1010AY.40.000016
ORF1ab/nsp3497K497RaAaaGa910B.10.000082
ORF1ab/nsp3497K497RaAAaGG110B.10.000009
ORF1ab/nsp3497K497RaAaaGa1010P.10.000158
ORF1ab/nsp3497K497KaaAaaG1010R.10.0009
ORF1ab/nsp3497K497KaaAaaG99AY.1160.002581
ORF1ab/nsp3497K497RaAaaGa99AY.440.000055
ORF1ab/nsp3497K497KaaAaaG99AY.440.000055
ORF1ab/nsp3497K497RaAaaGa99B.1.2210.000639
ORF1ab/nsp3497K497KaaAaaG88AY.430.000035
ORF1ab/nsp3497K497NaaAaaC57B.1.1.70.000004
ORF1ab/nsp3497K497NaaAaaT27B.1.1.70.000002
ORF1ab/nsp3497K497del1Aaa-aa66All0.000001
ORF1ab/nsp3497K497KaaAaaG55AY.470.000156
ORF1ab/nsp3497K497KaaAaaG55B.1.617.20.000019
ORF1ab/nsp3497K497TaAaaCa55Q.80.000825
ORF1ab/nsp3497K497RaAaaGa44AY.1110.000733
ORF1ab/nsp3497K497RaAaaGa44AY.250.000024
ORF1ab/nsp3497K497KaaAaaG44AY.29.10.000882
ORF1ab/nsp3497K497KaaAaaG44B.10.000037
ORF1ab/nsp3497K497KaaAaaG44B.1.1770.000053
ORF1ab/nsp3497K497RaAaaGa44B.1.3490.002859
ORF1ab/nsp3497K497SaAAaGC33All0.000001
ORF1ab/nsp3497K497RaAaaGa33AY.1030.000019
ORF1ab/nsp3497K497TaAaaCa33AY.200.000117
ORF1ab/nsp3497K497RaAaaGa33AY.30.00003
ORF1ab/nsp3497K497EAaaGaa33AY.40.000005
ORF1ab/nsp3497K497delAAA---33AY.430.000013
ORF1ab/nsp3497K497delAAA---33B.10.000027
ORF1ab/nsp3497K497delAAA---33B.1.1.70.000003
ORF1ab/nsp3497K497KaaAaaG33B.1.20.000026
ORF1ab/nsp3497K497QAaaCaa33B.1.4290.000071
ORF1ab/nsp3497K497RaAaaGa33B.1.617.20.000011
ORF1ab/nsp3497K497KaaAaaG220.111111
ORF1ab/nsp3497K497SaAAaGC220.111111
ORF1ab/nsp3497K497TaAAaCC220.111111
ORF1ab/nsp3497K497IaAaaTa220.111111
ORF1ab/nsp3497K497NaaAaaC220.111111
ORF1ab/nsp3497K497del2AAa--a22All0
ORF1ab/nsp3497K497RaAaaGa22AY.1020.000053
ORF1ab/nsp3497K497KaaAaaG22AY.1030.000012
ORF1ab/nsp3497K497KaaAaaG22AY.1090.001479
ORF1ab/nsp3497K497KaaAaaG22AY.250.000012
ORF1ab/nsp3497K497KaaAaaG22AY.30.00002
ORF1ab/nsp3497K497EAaaGaa22AY.430.000009
ORF1ab/nsp3497K497NaaAaaT12AY.430.000004
ORF1ab/nsp3497K497NaaAaaC12AY.430.000004
ORF1ab/nsp3497K497KaaAaaG22AY.460.000208
ORF1ab/nsp3497K497RaAaaGa22AY.470.000062
ORF1ab/nsp3497K497RaAaaGa22B.1.10.000036
ORF1ab/nsp3497K497KaaAaaG22B.1.10.000036
ORF1ab/nsp3497K497NaaAaaC12B.1.10.000018
ORF1ab/nsp3497K497NaaAaaT12B.1.10.000018
ORF1ab/nsp3497K497EAaaGaa22B.1.20.000018
ORF1ab/nsp3497K497TaAaaCa22B.1.20.000018
ORF1ab/nsp3497K497RaAaaGa22B.1.36.350.005208
ORF1ab/nsp3497K497KaaAaaG22B.1.4290.000047
ORF1ab/nsp3497K497KaaAaaG22B.1.5960.000174
ORF1ab/nsp3497K497QAaaCaa22B.1.617.20.000008
ORF1ab/nsp3497K497KaaAaaG22C.370.000232
ORF1ab/nsp3497K497RaAaaGa11A.2.50.000499
ORF1ab/nsp3497K497QAaaCaa11AA.70.009174
ORF1ab/nsp3497K497MaAAaTG11All0
ORF1ab/nsp3497K497LAAaCTa11All0
ORF1ab/nsp3497K497XAaaTaa11All0
ORF1ab/nsp3497K497KaaAaaG11AY.10.000396
ORF1ab/nsp3497K497del1Aaa-aa11AY.1000.000046
ORF1ab/nsp3497K497KaaAaaG11AY.1000.000046
ORF1ab/nsp3497K497delAAA---11AY.1030.000006
ORF1ab/nsp3497K497QAaaCaa11AY.1030.000006
ORF1ab/nsp3497K497KaaAaaG11AY.1110.000183
ORF1ab/nsp3497K497KaaAaaG11AY.1200.000037
ORF1ab/nsp3497K497KaaAaaG11AY.16.10.00047
ORF1ab/nsp3497K497delAAA---11AY.250.000006
ORF1ab/nsp3497K497EAaaGaa11AY.250.000006
ORF1ab/nsp3497K497QAaaCaa11AY.250.000006
ORF1ab/nsp3497K497RaAaaGa11AY.340.000097
ORF1ab/nsp3497K497EAaaGaa11AY.390.000025
ORF1ab/nsp3497K497NaaAaaT11AY.40.000002
ORF1ab/nsp3497K497QAaaCaa11AY.40.000002
ORF1ab/nsp3497K497EAaaGaa11AY.4.20.000022
ORF1ab/nsp3497K497delAAA---11AY.4.50.000107
ORF1ab/nsp3497K497QAaaCaa11AY.440.000006
ORF1ab/nsp3497K497MaAAaTG11AY.440.000006
ORF1ab/nsp3497K497del1Aaa-aa11AY.440.000006
ORF1ab/nsp3497K497NaaAaaT11AY.440.000006
ORF1ab/nsp3497K497KaaAaaG11AY.450.000122
ORF1ab/nsp3497K497QAaaCaa11AY.46.20.000635
ORF1ab/nsp3497K497KaaAaaG11AY.50.000021
ORF1ab/nsp3497K497NaaAaaT11AY.5.30.000337
ORF1ab/nsp3497K497KaaAaaG11AY.540.000095
ORF1ab/nsp3497K497RaAaaGa11AY.740.000116
ORF1ab/nsp3497K497delAAA---11AY.810.001992
ORF1ab/nsp3497K497TaAaaCa11AY.880.000884
ORF1ab/nsp3497K497EAaaGaa11AY.98.10.000048
ORF1ab/nsp3497K497delAAA---11AY.990.001049
ORF1ab/nsp3497K497IaAaaTa11B.10.000009
ORF1ab/nsp3497K497del1Aaa-aa11B.10.000009
ORF1ab/nsp3497K497EAaaGaa11B.10.000009
ORF1ab/nsp3497K497delAAA---11B.1.10.000018
ORF1ab/nsp3497K497KaaAaaG11B.1.1.100.001115
ORF1ab/nsp3497K497KaaAaaG11B.1.1.1410.002012
ORF1ab/nsp3497K497IaAaaTa11B.1.1.1530.001095
ORF1ab/nsp3497K497delAAA---11B.1.1.2160.00089
ORF1ab/nsp3497K497LAAaCTa11B.1.1.260.005236
ORF1ab/nsp3497K497KaaAaaG11B.1.1.3010.001179
ORF1ab/nsp3497K497RaAaaGa11B.1.1.3160.000925
ORF1ab/nsp3497K497KaaAaaG11B.1.1.3170.000412
ORF1ab/nsp3497K497delAAA---11B.1.1.5190.00004
ORF1ab/nsp3497K497KaaAaaG11B.1.1.5190.00004
ORF1ab/nsp3497K497del1Aaa-aa11B.1.1.70.000001
ORF1ab/nsp3497K497del2AAa--a11B.1.1.70.000001
ORF1ab/nsp3497K497EAaaGaa11B.1.1600.000031
ORF1ab/nsp3497K497QAaaCaa11B.1.1600.000031
ORF1ab/nsp3497K497TaAaaCa11B.1.1770.000013
ORF1ab/nsp3497K497EAaaGaa11B.1.1770.000013
ORF1ab/nsp3497K497QAaaCaa11B.1.177.210.000076
ORF1ab/nsp3497K497del1Aaa-aa11B.1.177.230.003236
ORF1ab/nsp3497K497KaaAaaG11B.1.177.320.00135
ORF1ab/nsp3497K497RaAaaGa11B.1.177.440.000519
ORF1ab/nsp3497K497NaaAaaC11B.1.177.450.000381
ORF1ab/nsp3497K497KaaAaaG11B.1.177.580.001332
ORF1ab/nsp3497K497KaaAaaG11B.1.177.70.000165
ORF1ab/nsp3497K497EAaaGaa11B.1.177.70.000165
ORF1ab/nsp3497K497delAAA---11B.1.177.860.000183
ORF1ab/nsp3497K497XAaaTaa11B.1.20.000009
ORF1ab/nsp3497K497NaaAaaC11B.1.20.000009
ORF1ab/nsp3497K497QAaaCaa11B.1.2210.000071
ORF1ab/nsp3497K497KaaAaaG11B.1.2400.000216
ORF1ab/nsp3497K497NaaAaaC11B.1.2580.000067
ORF1ab/nsp3497K497RaAaaGa11B.1.2580.000067
ORF1ab/nsp3497K497SaAAaGC11B.1.2580.000067
ORF1ab/nsp3497K497delAAA---11B.1.258.160.001637
ORF1ab/nsp3497K497RaAaaGa11B.1.3510.00003
ORF1ab/nsp3497K497delAAA---11B.1.360.000146
ORF1ab/nsp3497K497RaAaaGa11B.1.36.310.001751
ORF1ab/nsp3497K497RaAaaGa11B.1.4000.000429
ORF1ab/nsp3497K497RaAaaGa11B.1.4700.001404
ORF1ab/nsp3497K497RaAaaGa11B.1.5180.011765
ORF1ab/nsp3497K497NaaAaaC11B.1.5230.002451
ORF1ab/nsp3497K497EAaaGaa11B.1.5250.000113
ORF1ab/nsp3497K497RaAaaGa11B.1.5260.000024
ORF1ab/nsp3497K497RaAaaGa11B.1.5450.014493
ORF1ab/nsp3497K497TaAaaCa11B.1.617.20.000004
ORF1ab/nsp3497K497IaAaaTa11B.1.617.20.000004
ORF1ab/nsp3497K497NaaAaaC11B.1.617.20.000004
ORF1ab/nsp3497K497del2AAa--a11B.1.617.20.000004
ORF1ab/nsp3497K497del1Aaa-aa11B.1.617.30.002985
ORF1ab/nsp3497K497delAAA---11B.570.015152
ORF1ab/nsp3497K497RaAaaGa11C.260.007353
ORF1ab/nsp3497K497NaaAaaT11C.370.000116
ORF1ab/nsp3497K497delAAA---11P.10.000016
ORF1ab/nsp3497K497QAaaCaa11P.10.000016
ORF1ab/nsp3497K497KaaAaaG11P.1.10.000318
ORF1ab/nsp3497K497TaAaaCa11P.1.140.000048
ORF1ab/nsp3497K497KaaAaaG11P.1.40.000977
ORF1ab/nsp3497K497TaAaaCa11P.20.000187
ORF1ab/nsp3497K497RaAaaGa11Q.10.000126
ORF1ab/nsp3497K497delAAA---11R.10.00009
ORF1ab/nsp3497K497RaAaaGa11R.10.00009
ORF1ab/nsp3497K497delAAA---11U.30.003861

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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