CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 463

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3463K463QK1281QnonsynAaaCaa1332133214106-4108
ORF1ab/nsp3463K463KK1281KsynaaAaaG35335314106-4108
ORF1ab/nsp3463K463TK1281TnonsynaAaaCa11511514106-4108
ORF1ab/nsp3463K463EK1281EnonsynAaaGaa959514106-4108
ORF1ab/nsp3463K463RK1281RnonsynaAaaGa909014106-4108
ORF1ab/nsp3463K463NK1281NnonsynaaAaaC88540.6136364106-4108
ORF1ab/nsp3463K463NK1281NnonsynaaAaaT88340.3863644106-4108
ORF1ab/nsp3463K463delK1281deldelAAA---242414106-4108
ORF1ab/nsp3463K463del1K1281del1delAaa-aa1090.94106-4108
ORF1ab/nsp3463K463del1K1281del1delaaAaa-1010.14106-4108
ORF1ab/nsp3463K463IK1281InonsynaAaaTa3314106-4108
ORF1ab/nsp3463K463del2K1281del2delAAa--a1114106-4108
ORF1ab/nsp3463K463XK1281XnonsynAaaTaa1114106-4108
ORF1ab/nsp3463K463GK1281GnonsynAAaGGa1114106-4108
ORF1ab/nsp3463K463AK1281AnonsynAAaGCa1114106-4108

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3463K463QAaaCaa13321332All0.000255
ORF1ab/nsp3463K463QAaaCaa12621262B.1.5260.029663
ORF1ab/nsp3463K463KaaAaaG353353All0.000068
ORF1ab/nsp3463K463KaaAaaG169169B.1.1.2430.689796
ORF1ab/nsp3463K463TaAaaCa115115All0.000022
ORF1ab/nsp3463K463EAaaGaa9595All0.000018
ORF1ab/nsp3463K463RaAaaGa9090All0.000017
ORF1ab/nsp3463K463NaaAaaC5488All0.00001
ORF1ab/nsp3463K463NaaAaaT3488All0.000007
ORF1ab/nsp3463K463TaAaaCa8888AY.440.000536
ORF1ab/nsp3463K463KaaAaaG4545AY.840.019685
ORF1ab/nsp3463K463KaaAaaG2626AY.40.00004
ORF1ab/nsp3463K463delAAA---2424All0.000005
ORF1ab/nsp3463K463KaaAaaG2323B.1.1.70.000021
ORF1ab/nsp3463K463NaaAaaT2222P.1.120.010649
ORF1ab/nsp3463K463NaaAaaC2121B.1.1.70.000019
ORF1ab/nsp3463K463EAaaGaa1919B.1.1160.22093
ORF1ab/nsp3463K463QAaaCaa1818AY.30.000179
ORF1ab/nsp3463K463RaAaaGa1818B.1.1.70.000016
ORF1ab/nsp3463K463KaaAaaG1616AY.440.000097
ORF1ab/nsp3463K463EAaaGaa1515AY.750.00084
ORF1ab/nsp3463K463RaAaaGa1313AY.1130.001851
ORF1ab/nsp3463K463TaAaaCa1111B.1.617.20.000041
ORF1ab/nsp3463K463del1Aaa-aa910All0.000002
ORF1ab/nsp3463K463del1aaAaa-110All0
ORF1ab/nsp3463K463EAaaGaa1010B.1.2400.002156
ORF1ab/nsp3463K463EAaaGaa99AY.90.000608
ORF1ab/nsp3463K463RaAaaGa99B.1.1770.000119
ORF1ab/nsp3463K463KaaAaaG99B.1.3510.000268
ORF1ab/nsp3463K463RaAaaGa88AY.30.00008
ORF1ab/nsp3463K463QAaaCaa88B.1.20.00007
ORF1ab/nsp3463K463KaaAaaG77AE.80.003423
ORF1ab/nsp3463K463QAaaCaa77AY.250.000042
ORF1ab/nsp3463K463delAAA---77B.1.1.70.000006
ORF1ab/nsp3463K463QAaaCaa66AY.200.000233
ORF1ab/nsp3463K463TaAaaCa66B.1.4330.019169
ORF1ab/nsp3463K463QAaaCaa55AY.1020.000133
ORF1ab/nsp3463K463KaaAaaG55AY.430.000022
ORF1ab/nsp3463K463EAaaGaa55B.10.000046
ORF1ab/nsp3463K463RaAaaGa55B.1.5260.000118
ORF1ab/nsp3463K463KaaAaaG55B.1.617.20.000019
ORF1ab/nsp3463K463KaaAaaG55B.1.6210.000443
ORF1ab/nsp3463K463KaaAaaG55P.10.000079
ORF1ab/nsp3463K463QAaaCaa44AY.430.000018
ORF1ab/nsp3463K463KaaAaaG44AY.98.10.000194
ORF1ab/nsp3463K463RaAaaGa44B.10.000037
ORF1ab/nsp3463K463QAaaCaa44B.10.000037
ORF1ab/nsp3463K463RaAaaGa44B.1.1.2280.012195
ORF1ab/nsp3463K463EAaaGaa44B.1.1.70.000004
ORF1ab/nsp3463K463NaaAaaC44B.1.3510.000119
ORF1ab/nsp3463K463NaaAaaT44B.1.4290.000094
ORF1ab/nsp3463K463NaaAaaC44C.160.004242
ORF1ab/nsp3463K463IaAaaTa33All0.000001
ORF1ab/nsp3463K463RaAaaGa33AY.440.000018
ORF1ab/nsp3463K463RaAaaGa33AY.9.10.000251
ORF1ab/nsp3463K463del1Aaa-aa33B.10.000027
ORF1ab/nsp3463K463delAAA---33B.10.000027
ORF1ab/nsp3463K463KaaAaaG33B.1.10.000054
ORF1ab/nsp3463K463NaaAaaT33B.1.1.5190.000119
ORF1ab/nsp3463K463QAaaCaa33B.1.1.70.000003
ORF1ab/nsp3463K463TaAaaCa33B.1.1.70.000003
ORF1ab/nsp3463K463KaaAaaG33B.1.416.10.004687
ORF1ab/nsp3463K463KaaAaaG33B.1.780.025641
ORF1ab/nsp3463K463EAaaGaa33P.10.000047
ORF1ab/nsp3463K463QAaaCaa33P.1.70.000958
ORF1ab/nsp3463K463RaAaaGa22AY.1030.000012
ORF1ab/nsp3463K463TaAaaCa22AY.1030.000012
ORF1ab/nsp3463K463KaaAaaG22AY.250.000012
ORF1ab/nsp3463K463RaAaaGa22AY.250.000012
ORF1ab/nsp3463K463KaaAaaG22AY.260.000057
ORF1ab/nsp3463K463NaaAaaC22AY.290.000032
ORF1ab/nsp3463K463TaAaaCa22AY.390.000049
ORF1ab/nsp3463K463NaaAaaC22AY.40.000003
ORF1ab/nsp3463K463EAaaGaa22AY.40.000003
ORF1ab/nsp3463K463RaAaaGa22AY.430.000009
ORF1ab/nsp3463K463QAaaCaa22AY.440.000012
ORF1ab/nsp3463K463EAaaGaa22AY.440.000012
ORF1ab/nsp3463K463NaaAaaC22AY.450.000243
ORF1ab/nsp3463K463NaaAaaC22AY.470.000062
ORF1ab/nsp3463K463EAaaGaa22B.1.10.000036
ORF1ab/nsp3463K463EAaaGaa22B.1.1.2220.000408
ORF1ab/nsp3463K463QAaaCaa22B.1.1.3120.003824
ORF1ab/nsp3463K463KaaAaaG22B.1.1.330.000842
ORF1ab/nsp3463K463RaAaaGa22B.1.1.630.000772
ORF1ab/nsp3463K463EAaaGaa22B.1.1600.000062
ORF1ab/nsp3463K463NaaAaaC22B.1.1600.000062
ORF1ab/nsp3463K463EAaaGaa22B.1.20.000018
ORF1ab/nsp3463K463IaAaaTa22B.1.2240.05
ORF1ab/nsp3463K463EAaaGaa22B.1.4280.002041
ORF1ab/nsp3463K463EAaaGaa22B.1.4410.019231
ORF1ab/nsp3463K463RaAaaGa22B.1.617.10.000258
ORF1ab/nsp3463K463NaaAaaC12B.1.617.20.000004
ORF1ab/nsp3463K463NaaAaaT12B.1.617.20.000004
ORF1ab/nsp3463K463del1Aaa-aa22B.1.6270.00404
ORF1ab/nsp3463K463NaaAaaC22R.20.028986
ORF1ab/nsp3463K463GAAaGGa110.055556
ORF1ab/nsp3463K463RaAaaGa110.055556
ORF1ab/nsp3463K463EAaaGaa110.055556
ORF1ab/nsp3463K463GAAaGGa11All0
ORF1ab/nsp3463K463del2AAa--a11All0
ORF1ab/nsp3463K463XAaaTaa11All0
ORF1ab/nsp3463K463AAAaGCa11All0
ORF1ab/nsp3463K463KaaAaaG11AY.1000.000046
ORF1ab/nsp3463K463EAaaGaa11AY.1020.000027
ORF1ab/nsp3463K463KaaAaaG11AY.1030.000006
ORF1ab/nsp3463K463RaAaaGa11AY.1060.000335
ORF1ab/nsp3463K463EAaaGaa11AY.116.10.000311
ORF1ab/nsp3463K463QAaaCaa11AY.1180.000063
ORF1ab/nsp3463K463KaaAaaG11AY.1200.000037
ORF1ab/nsp3463K463delAAA---11AY.1200.000037
ORF1ab/nsp3463K463NaaAaaT11AY.160.00038
ORF1ab/nsp3463K463EAaaGaa11AY.250.000006
ORF1ab/nsp3463K463NaaAaaT11AY.250.000006
ORF1ab/nsp3463K463TaAaaCa11AY.30.00001
ORF1ab/nsp3463K463KaaAaaG11AY.30.00001
ORF1ab/nsp3463K463NaaAaaC11AY.30.00001
ORF1ab/nsp3463K463KaaAaaG11AY.330.000067
ORF1ab/nsp3463K463EAaaGaa11AY.390.000025
ORF1ab/nsp3463K463QAaaCaa11AY.39.10.00004
ORF1ab/nsp3463K463del1Aaa-aa11AY.40.000002
ORF1ab/nsp3463K463QAaaCaa11AY.40.000002
ORF1ab/nsp3463K463RaAaaGa11AY.40.000002
ORF1ab/nsp3463K463del1aaAaa-11AY.4.50.000107
ORF1ab/nsp3463K463EAaaGaa11AY.430.000004
ORF1ab/nsp3463K463NaaAaaC11AY.430.000004
ORF1ab/nsp3463K463delAAA---11AY.430.000004
ORF1ab/nsp3463K463delAAA---11AY.46.60.000072
ORF1ab/nsp3463K463KaaAaaG11AY.470.000031
ORF1ab/nsp3463K463KaaAaaG11AY.510.000909
ORF1ab/nsp3463K463KaaAaaG11AY.520.000814
ORF1ab/nsp3463K463TaAaaCa11AY.550.000917
ORF1ab/nsp3463K463NaaAaaC11AY.60.000041
ORF1ab/nsp3463K463KaaAaaG11AY.610.000105
ORF1ab/nsp3463K463RaAaaGa11AY.610.000105
ORF1ab/nsp3463K463KaaAaaG11AY.650.000533
ORF1ab/nsp3463K463delAAA---11AY.670.000464
ORF1ab/nsp3463K463RaAaaGa11AY.90.000068
ORF1ab/nsp3463K463EAaaGaa11AY.9.20.000037
ORF1ab/nsp3463K463TaAaaCa11B.10.000009
ORF1ab/nsp3463K463NaaAaaC11B.10.000009
ORF1ab/nsp3463K463AAAaGCa11B.10.000009
ORF1ab/nsp3463K463KaaAaaG11B.1.1.1740.003378
ORF1ab/nsp3463K463KaaAaaG11B.1.1.1920.002309
ORF1ab/nsp3463K463RaAaaGa11B.1.1.2160.00089
ORF1ab/nsp3463K463KaaAaaG11B.1.1.2800.003086
ORF1ab/nsp3463K463KaaAaaG11B.1.1.3090.005848
ORF1ab/nsp3463K463RaAaaGa11B.1.1.3170.000412
ORF1ab/nsp3463K463EAaaGaa11B.1.1.3180.000302
ORF1ab/nsp3463K463NaaAaaC11B.1.1.370.000193
ORF1ab/nsp3463K463EAaaGaa11B.1.1.3720.000689
ORF1ab/nsp3463K463KaaAaaG11B.1.1.3980.003226
ORF1ab/nsp3463K463QAaaCaa11B.1.1.4200.001006
ORF1ab/nsp3463K463delAAA---11B.1.1.5190.00004
ORF1ab/nsp3463K463IaAaaTa11B.1.1.70.000001
ORF1ab/nsp3463K463NaaAaaC11B.1.1.700.000341
ORF1ab/nsp3463K463KaaAaaG11B.1.1280.000635
ORF1ab/nsp3463K463delAAA---11B.1.177.160.000664
ORF1ab/nsp3463K463KaaAaaG11B.1.177.230.003236
ORF1ab/nsp3463K463delAAA---11B.1.177.40.000211
ORF1ab/nsp3463K463EAaaGaa11B.1.177.70.000165
ORF1ab/nsp3463K463NaaAaaC11B.1.177.70.000165
ORF1ab/nsp3463K463NaaAaaC11B.1.177.80.000752
ORF1ab/nsp3463K463RaAaaGa11B.1.177.810.000189
ORF1ab/nsp3463K463del2AAa--a11B.1.177.860.000183
ORF1ab/nsp3463K463QAaaCaa11B.1.177.870.000728
ORF1ab/nsp3463K463del1Aaa-aa11B.1.20.000009
ORF1ab/nsp3463K463delAAA---11B.1.2210.000071
ORF1ab/nsp3463K463RaAaaGa11B.1.2320.000537
ORF1ab/nsp3463K463QAaaCaa11B.1.2430.00007
ORF1ab/nsp3463K463RaAaaGa11B.1.258.170.000104
ORF1ab/nsp3463K463EAaaGaa11B.1.3510.00003
ORF1ab/nsp3463K463RaAaaGa11B.1.3510.00003
ORF1ab/nsp3463K463RaAaaGa11B.1.360.000146
ORF1ab/nsp3463K463KaaAaaG11B.1.360.000146
ORF1ab/nsp3463K463delAAA---11B.1.360.000146
ORF1ab/nsp3463K463delAAA---11B.1.4290.000024
ORF1ab/nsp3463K463del1Aaa-aa11B.1.4320.011236
ORF1ab/nsp3463K463NaaAaaC11B.1.438.10.000107
ORF1ab/nsp3463K463KaaAaaG11B.1.4700.001404
ORF1ab/nsp3463K463QAaaCaa11B.1.5300.007143
ORF1ab/nsp3463K463EAaaGaa11B.1.5950.000261
ORF1ab/nsp3463K463NaaAaaC11B.1.5960.000087
ORF1ab/nsp3463K463RaAaaGa11B.1.617.20.000004
ORF1ab/nsp3463K463del1Aaa-aa11B.1.617.20.000004
ORF1ab/nsp3463K463EAaaGaa11B.1.617.20.000004
ORF1ab/nsp3463K463NaaAaaC11B.1.6370.000073
ORF1ab/nsp3463K463delAAA---11B.570.015152
ORF1ab/nsp3463K463XAaaTaa11D.20.000075
ORF1ab/nsp3463K463NaaAaaT11D.20.000075
ORF1ab/nsp3463K463delAAA---11P.10.000016
ORF1ab/nsp3463K463EAaaGaa11P.1.130.000898
ORF1ab/nsp3463K463NaaAaaC11P.1.140.000048
ORF1ab/nsp3463K463NaaAaaT11P.1.150.000232
ORF1ab/nsp3463K463QAaaCaa11Q.80.000165
ORF1ab/nsp3463K463delAAA---11R.10.00009
ORF1ab/nsp3463K463delAAA---11U.30.003861

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.