CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp3 : CodonNum = 327

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp3327L327LL1145LsynctTctA128811080.8602483698-3700
ORF1ab/nsp3327L327LL1145LsynctTctG1288910.07065223698-3700
ORF1ab/nsp3327L327LL1145LsynctTctC1288890.06909943698-3700
ORF1ab/nsp3327L327FL1145FnonsynCttTtt57657613698-3700
ORF1ab/nsp3327L327IL1145InonsynCttAtt12312313698-3700
ORF1ab/nsp3327L327delL1145deldelCTT---10410413698-3700
ORF1ab/nsp3327L327VL1145VnonsynCttGtt303013698-3700
ORF1ab/nsp3327L327RL1145RnonsyncTtcGt970.7777783698-3700
ORF1ab/nsp3327L327RL1145RnonsyncTTcGC910.1111113698-3700
ORF1ab/nsp3327L327RL1145RnonsynCTTAGG910.1111113698-3700
ORF1ab/nsp3327L327PL1145PnonsyncTtcCt8813698-3700
ORF1ab/nsp3327L327del1L1145del1delcTtc-t760.8571433698-3700
ORF1ab/nsp3327L327del1L1145del1delCtt-tt710.1428573698-3700
ORF1ab/nsp3327L327HL1145HnonsyncTtcAt5513698-3700
ORF1ab/nsp3327L327SL1145SnonsynCTtAGt420.53698-3700
ORF1ab/nsp3327L327SL1145SnonsynCTTTCG410.253698-3700
ORF1ab/nsp3327L327SL1145SnonsynCTTTCA410.253698-3700
ORF1ab/nsp3327L327del2L1145del2delcTTc--320.6666673698-3700
ORF1ab/nsp3327L327del2L1145del2delCTt--t310.3333333698-3700
ORF1ab/nsp3327L327TL1145TnonsynCTTACA1113698-3700
ORF1ab/nsp3327L327GL1145GnonsynCTtGGt1113698-3700

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp3327L327LctTctA11081288All0.000212
ORF1ab/nsp3327L327LctTctG911288All0.000017
ORF1ab/nsp3327L327LctTctC891288All0.000017
ORF1ab/nsp3327L327FCttTtt576576All0.00011
ORF1ab/nsp3327L327LctTctA458459B.1.617.20.001725
ORF1ab/nsp3327L327LctTctG1459B.1.617.20.000004
ORF1ab/nsp3327L327LctTctA274277AY.430.001214
ORF1ab/nsp3327L327LctTctC3277AY.430.000013
ORF1ab/nsp3327L327LctTctA176201B.1.1.70.000158
ORF1ab/nsp3327L327LctTctC16201B.1.1.70.000014
ORF1ab/nsp3327L327LctTctG9201B.1.1.70.000008
ORF1ab/nsp3327L327ICttAtt123123All0.000024
ORF1ab/nsp3327L327delCTT---104104All0.00002
ORF1ab/nsp3327L327FCttTtt7878B.1.36.330.590909
ORF1ab/nsp3327L327LctTctG7375B.1.1770.000961
ORF1ab/nsp3327L327LctTctA275B.1.1770.000026
ORF1ab/nsp3327L327FCttTtt6969B.1.1.70.000062
ORF1ab/nsp3327L327ICttAtt4949AY.40.000076
ORF1ab/nsp3327L327FCttTtt4242AY.40.000065
ORF1ab/nsp3327L327FCttTtt3939P.20.007279
ORF1ab/nsp3327L327FCttTtt3131B.1.177.210.002371
ORF1ab/nsp3327L327VCttGtt3030All0.000006
ORF1ab/nsp3327L327LctTctA2829AY.440.00017
ORF1ab/nsp3327L327LctTctC129AY.440.000006
ORF1ab/nsp3327L327FCttTtt2929B.1.10.000526
ORF1ab/nsp3327L327FCttTtt2929B.1.617.20.000109
ORF1ab/nsp3327L327ICttAtt2828AY.9.10.002344
ORF1ab/nsp3327L327LctTctA2323AY.200.000894
ORF1ab/nsp3327L327FCttTtt2222B.1.5260.000517
ORF1ab/nsp3327L327FCttTtt2121AY.430.000093
ORF1ab/nsp3327L327LctTctC1419AY.1030.000087
ORF1ab/nsp3327L327LctTctA519AY.1030.000031
ORF1ab/nsp3327L327LctTctA1319AY.40.00002
ORF1ab/nsp3327L327LctTctC519AY.40.000008
ORF1ab/nsp3327L327LctTctG119AY.40.000002
ORF1ab/nsp3327L327delCTT---1919P.1.150.004414
ORF1ab/nsp3327L327VCttGtt1818AY.40.000028
ORF1ab/nsp3327L327LctTctA1617AY.390.000395
ORF1ab/nsp3327L327LctTctC117AY.390.000025
ORF1ab/nsp3327L327delCTT---1616P.10.000252
ORF1ab/nsp3327L327FCttTtt1515AY.250.00009
ORF1ab/nsp3327L327LctTctA1515AY.460.001561
ORF1ab/nsp3327L327FCttTtt1313AY.1030.000081
ORF1ab/nsp3327L327FCttTtt1313B.1.20.000114
ORF1ab/nsp3327L327FCttTtt1212Q.10.001516
ORF1ab/nsp3327L327FCttTtt1010AZ.30.015198
ORF1ab/nsp3327L327FCttTtt1010B.1.1.2220.00204
ORF1ab/nsp3327L327delCTT---1010P.1.120.00484
ORF1ab/nsp3327L327RcTtcGt79All0.000001
ORF1ab/nsp3327L327RCTTAGG19All0
ORF1ab/nsp3327L327RcTTcGC19All0
ORF1ab/nsp3327L327LctTctA89AY.1020.000212
ORF1ab/nsp3327L327LctTctC19AY.1020.000027
ORF1ab/nsp3327L327FCttTtt99B.10.000082
ORF1ab/nsp3327L327PcTtcCt88All0.000002
ORF1ab/nsp3327L327delCTT---88B.10.000073
ORF1ab/nsp3327L327LctTctC58B.10.000046
ORF1ab/nsp3327L327LctTctA38B.10.000027
ORF1ab/nsp3327L327FCttTtt88B.1.1600.00025
ORF1ab/nsp3327L327del1cTtc-t67All0.000001
ORF1ab/nsp3327L327del1Ctt-tt17All0
ORF1ab/nsp3327L327ICttAtt77AY.440.000043
ORF1ab/nsp3327L327LctTctA77AY.840.003062
ORF1ab/nsp3327L327LctTctA67AY.98.10.000291
ORF1ab/nsp3327L327LctTctC17AY.98.10.000048
ORF1ab/nsp3327L327LctTctC57B.1.1.5190.000199
ORF1ab/nsp3327L327LctTctA27B.1.1.5190.000079
ORF1ab/nsp3327L327FCttTtt77B.1.1770.000092
ORF1ab/nsp3327L327VCttGtt77B.1.617.20.000026
ORF1ab/nsp3327L327FCttTtt66AY.440.000037
ORF1ab/nsp3327L327LctTctA56AY.50.000103
ORF1ab/nsp3327L327LctTctC16AY.50.000021
ORF1ab/nsp3327L327ICttAtt66AY.640.003571
ORF1ab/nsp3327L327LctTctA56B.1.2580.000333
ORF1ab/nsp3327L327LctTctC16B.1.2580.000067
ORF1ab/nsp3327L327FCttTtt66P.10.000095
ORF1ab/nsp3327L327HcTtcAt55All0.000001
ORF1ab/nsp3327L327FCttTtt55AY.1020.000133
ORF1ab/nsp3327L327FCttTtt55AY.610.000524
ORF1ab/nsp3327L327LctTctC55B.1.1600.000156
ORF1ab/nsp3327L327ICttAtt55B.1.1770.000066
ORF1ab/nsp3327L327LctTctC55B.1.4290.000118
ORF1ab/nsp3327L327ICttAtt55B.1.617.20.000019
ORF1ab/nsp3327L327SCTtAGt24All0
ORF1ab/nsp3327L327SCTTTCG14All0
ORF1ab/nsp3327L327SCTTTCA14All0
ORF1ab/nsp3327L327FCttTtt44AY.1190.000141
ORF1ab/nsp3327L327LctTctA24AY.250.000012
ORF1ab/nsp3327L327LctTctC14AY.250.000006
ORF1ab/nsp3327L327LctTctG14AY.250.000006
ORF1ab/nsp3327L327FCttTtt44AY.4.20.000087
ORF1ab/nsp3327L327LctTctA34AY.4.20.000065
ORF1ab/nsp3327L327LctTctC14AY.4.20.000022
ORF1ab/nsp3327L327delCTT---44B.1.1.70.000004
ORF1ab/nsp3327L327delCTT---44B.1.6210.000354
ORF1ab/nsp3327L327FCttTtt44B.1.6370.000292
ORF1ab/nsp3327L327LctTctG44C.36.30.002269
ORF1ab/nsp3327L327RcTtcGt330.166667
ORF1ab/nsp3327L327del2cTTc--23All0
ORF1ab/nsp3327L327del2CTt--t13All0
ORF1ab/nsp3327L327FCttTtt33AY.200.000117
ORF1ab/nsp3327L327LctTctC33AY.30.00003
ORF1ab/nsp3327L327delCTT---33AY.430.000013
ORF1ab/nsp3327L327ICttAtt33AY.430.000013
ORF1ab/nsp3327L327ICttAtt33AY.46.20.001906
ORF1ab/nsp3327L327LctTctA33AY.560.004815
ORF1ab/nsp3327L327LctTctA33AY.920.000862
ORF1ab/nsp3327L327delCTT---33B.1.10.000054
ORF1ab/nsp3327L327FCttTtt33B.1.1.2770.002276
ORF1ab/nsp3327L327ICttAtt33B.1.1.70.000003
ORF1ab/nsp3327L327del1cTtc-t33B.1.1.70.000003
ORF1ab/nsp3327L327LctTctA33B.1.177.600.000655
ORF1ab/nsp3327L327LctTctA23B.1.20.000018
ORF1ab/nsp3327L327LctTctC13B.1.20.000009
ORF1ab/nsp3327L327FCttTtt33B.1.4290.000071
ORF1ab/nsp3327L327LctTctA33P.10.000047
ORF1ab/nsp3327L327delCTT---33P.1.140.000143
ORF1ab/nsp3327L327delCTT---220.111111
ORF1ab/nsp3327L327del2cTTc--220.111111
ORF1ab/nsp3327L327SCTtAGt220.111111
ORF1ab/nsp3327L327LctTctA22AY.1000.000092
ORF1ab/nsp3327L327FCttTtt22AY.1010.000981
ORF1ab/nsp3327L327ICttAtt22AY.1030.000012
ORF1ab/nsp3327L327LctTctA22AY.1160.000574
ORF1ab/nsp3327L327LctTctA22AY.1170.000169
ORF1ab/nsp3327L327LctTctA12AY.1190.000035
ORF1ab/nsp3327L327LctTctC12AY.1190.000035
ORF1ab/nsp3327L327VCttGtt22AY.250.000012
ORF1ab/nsp3327L327delCTT---22AY.250.000012
ORF1ab/nsp3327L327LctTctC12AY.260.000028
ORF1ab/nsp3327L327LctTctA12AY.260.000028
ORF1ab/nsp3327L327FCttTtt22AY.290.000032
ORF1ab/nsp3327L327LctTctA22AY.330.000134
ORF1ab/nsp3327L327FCttTtt22AY.330.000134
ORF1ab/nsp3327L327LctTctA22AY.34.10.00102
ORF1ab/nsp3327L327LctTctA22AY.370.000632
ORF1ab/nsp3327L327FCttTtt22AY.390.000049
ORF1ab/nsp3327L327del1cTtc-t22AY.440.000012
ORF1ab/nsp3327L327FCttTtt22AY.450.000243
ORF1ab/nsp3327L327LctTctA22AY.5.40.000553
ORF1ab/nsp3327L327LctTctA22AY.610.00021
ORF1ab/nsp3327L327LctTctC12AY.690.000187
ORF1ab/nsp3327L327LctTctA12AY.690.000187
ORF1ab/nsp3327L327LctTctC22B0.000256
ORF1ab/nsp3327L327FCttTtt22B.1.1.1250.020408
ORF1ab/nsp3327L327PcTtcCt22B.1.1.70.000002
ORF1ab/nsp3327L327LctTctC22B.1.1.700.000682
ORF1ab/nsp3327L327FCttTtt22B.1.177.350.001382
ORF1ab/nsp3327L327FCttTtt22B.1.177.420.001789
ORF1ab/nsp3327L327LctTctC12B.1.2430.00007
ORF1ab/nsp3327L327LctTctA12B.1.2430.00007
ORF1ab/nsp3327L327ICttAtt22B.1.36.70.008
ORF1ab/nsp3327L327delCTT---22B.1.5960.000174
ORF1ab/nsp3327L327LctTctA22B.1.5960.000174
ORF1ab/nsp3327L327delCTT---22B.1.617.20.000008
ORF1ab/nsp3327L327delCTT---22C.370.000232
ORF1ab/nsp3327L327delCTT---22N.60.014184
ORF1ab/nsp3327L327delCTT---22P.1.70.000639
ORF1ab/nsp3327L327LctTctA22P.20.000373
ORF1ab/nsp3327L327HcTtcAt110.055556
ORF1ab/nsp3327L327FCttTtt11AL.10.012987
ORF1ab/nsp3327L327GCTtGGt11All0
ORF1ab/nsp3327L327TCTTACA11All0
ORF1ab/nsp3327L327FCttTtt11AP.10.001502
ORF1ab/nsp3327L327PcTtcCt11AY.1030.000006
ORF1ab/nsp3327L327FCttTtt11AY.1050.000643
ORF1ab/nsp3327L327LctTctA11AY.1050.000643
ORF1ab/nsp3327L327FCttTtt11AY.1060.000335
ORF1ab/nsp3327L327FCttTtt11AY.1100.000113
ORF1ab/nsp3327L327delCTT---11AY.1130.000142
ORF1ab/nsp3327L327FCttTtt11AY.1140.000231
ORF1ab/nsp3327L327VCttGtt11AY.1180.000063
ORF1ab/nsp3327L327LctTctA11AY.1180.000063
ORF1ab/nsp3327L327delCTT---11AY.1190.000035
ORF1ab/nsp3327L327FCttTtt11AY.1200.000037
ORF1ab/nsp3327L327LctTctA11AY.1200.000037
ORF1ab/nsp3327L327FCttTtt11AY.120.10.000321
ORF1ab/nsp3327L327FCttTtt11AY.140.000088
ORF1ab/nsp3327L327ICttAtt11AY.200.000039
ORF1ab/nsp3327L327ICttAtt11AY.230.00007
ORF1ab/nsp3327L327delCTT---11AY.230.00007
ORF1ab/nsp3327L327delCTT---11AY.240.000431
ORF1ab/nsp3327L327delCTT---11AY.260.000028
ORF1ab/nsp3327L327LctTctA11AY.290.000016
ORF1ab/nsp3327L327VCttGtt11AY.290.000016
ORF1ab/nsp3327L327ICttAtt11AY.30.00001
ORF1ab/nsp3327L327LctTctA11AY.320.000532
ORF1ab/nsp3327L327LctTctC11AY.340.000097
ORF1ab/nsp3327L327FCttTtt11AY.370.000316
ORF1ab/nsp3327L327FCttTtt11AY.39.10.00004
ORF1ab/nsp3327L327HcTtcAt11AY.40.000002
ORF1ab/nsp3327L327FCttTtt11AY.4.2.10.000149
ORF1ab/nsp3327L327FCttTtt11AY.420.00004
ORF1ab/nsp3327L327delCTT---11AY.440.000006
ORF1ab/nsp3327L327RcTtcGt11AY.440.000006
ORF1ab/nsp3327L327del2CTt--t11AY.440.000006
ORF1ab/nsp3327L327FCttTtt11AY.46.30.000934
ORF1ab/nsp3327L327FCttTtt11AY.470.000031
ORF1ab/nsp3327L327FCttTtt11AY.50.000021
ORF1ab/nsp3327L327FCttTtt11AY.60.000041
ORF1ab/nsp3327L327delCTT---11AY.670.000464
ORF1ab/nsp3327L327LctTctA11AY.700.000209
ORF1ab/nsp3327L327FCttTtt11AY.750.000056
ORF1ab/nsp3327L327FCttTtt11AY.790.001211
ORF1ab/nsp3327L327delCTT---11AY.840.000437
ORF1ab/nsp3327L327FCttTtt11AY.9.10.000084
ORF1ab/nsp3327L327LctTctA11AY.9.20.000037
ORF1ab/nsp3327L327FCttTtt11AY.9.20.000037
ORF1ab/nsp3327L327ICttAtt11AY.9.20.000037
ORF1ab/nsp3327L327FCttTtt11AY.910.00073
ORF1ab/nsp3327L327LctTctA11AY.980.000079
ORF1ab/nsp3327L327TCTTACA11AY.990.001049
ORF1ab/nsp3327L327FCttTtt11AY.99.20.000092
ORF1ab/nsp3327L327LctTctA11AY.99.20.000092
ORF1ab/nsp3327L327PcTtcCt11B0.000128
ORF1ab/nsp3327L327ICttAtt11B.10.000009
ORF1ab/nsp3327L327HcTtcAt11B.10.000009
ORF1ab/nsp3327L327del1cTtc-t11B.10.000009
ORF1ab/nsp3327L327LctTctA11B.1.10.000018
ORF1ab/nsp3327L327FCttTtt11B.1.1.1530.001095
ORF1ab/nsp3327L327FCttTtt11B.1.1.1630.007634
ORF1ab/nsp3327L327LctTctA11B.1.1.1700.001247
ORF1ab/nsp3327L327LctTctC11B.1.1.2140.000055
ORF1ab/nsp3327L327LctTctC11B.1.1.2220.000204
ORF1ab/nsp3327L327FCttTtt11B.1.1.280.000311
ORF1ab/nsp3327L327delCTT---11B.1.1.3060.000438
ORF1ab/nsp3327L327FCttTtt11B.1.1.3260.001761
ORF1ab/nsp3327L327delCTT---11B.1.1.330.000421
ORF1ab/nsp3327L327LctTctC11B.1.1.330.000421
ORF1ab/nsp3327L327delCTT---11B.1.1.3480.000796
ORF1ab/nsp3327L327LctTctC11B.1.1.3480.000796
ORF1ab/nsp3327L327FCttTtt11B.1.1.3700.012658
ORF1ab/nsp3327L327FCttTtt11B.1.1.3880.045455
ORF1ab/nsp3327L327LctTctA11B.1.1.390.00051
ORF1ab/nsp3327L327FCttTtt11B.1.1.4340.000349
ORF1ab/nsp3327L327LctTctA11B.1.1.4580.041667
ORF1ab/nsp3327L327FCttTtt11B.1.1.5190.00004
ORF1ab/nsp3327L327FCttTtt11B.1.1.5230.001563
ORF1ab/nsp3327L327FCttTtt11B.1.1.630.000386
ORF1ab/nsp3327L327SCTTTCA11B.1.1.70.000001
ORF1ab/nsp3327L327GCTtGGt11B.1.1.70.000001
ORF1ab/nsp3327L327VCttGtt11B.1.1.70.000001
ORF1ab/nsp3327L327RcTtcGt11B.1.1.70.000001
ORF1ab/nsp3327L327delCTT---11B.1.110.30.000718
ORF1ab/nsp3327L327LctTctA11B.1.1590.012195
ORF1ab/nsp3327L327FCttTtt11B.1.160.200.008929
ORF1ab/nsp3327L327FCttTtt11B.1.160.330.004425
ORF1ab/nsp3327L327PcTtcCt11B.1.177.120.000152
ORF1ab/nsp3327L327LctTctA11B.1.177.170.000821
ORF1ab/nsp3327L327HcTtcAt11B.1.177.230.003236
ORF1ab/nsp3327L327LctTctA11B.1.177.40.000211
ORF1ab/nsp3327L327FCttTtt11B.1.177.530.002392
ORF1ab/nsp3327L327FCttTtt11B.1.177.600.000218
ORF1ab/nsp3327L327LctTctC11B.1.177.730.000566
ORF1ab/nsp3327L327FCttTtt11B.1.177.830.001481
ORF1ab/nsp3327L327ICttAtt11B.1.20.000009
ORF1ab/nsp3327L327delCTT---11B.1.2180.005155
ORF1ab/nsp3327L327FCttTtt11B.1.2340.000132
ORF1ab/nsp3327L327LctTctC11B.1.2340.000132
ORF1ab/nsp3327L327RcTTcGC11B.1.2340.000132
ORF1ab/nsp3327L327FCttTtt11B.1.2400.000216
ORF1ab/nsp3327L327FCttTtt11B.1.243.20.014493
ORF1ab/nsp3327L327FCttTtt11B.1.2580.000067
ORF1ab/nsp3327L327FCttTtt11B.1.258.170.000104
ORF1ab/nsp3327L327FCttTtt11B.1.3050.002151
ORF1ab/nsp3327L327FCttTtt11B.1.3240.001605
ORF1ab/nsp3327L327RcTtcGt11B.1.3320.003497
ORF1ab/nsp3327L327FCttTtt11B.1.3490.000715
ORF1ab/nsp3327L327LctTctA11B.1.3510.00003
ORF1ab/nsp3327L327FCttTtt11B.1.3510.00003
ORF1ab/nsp3327L327RCTTAGG11B.1.3510.00003
ORF1ab/nsp3327L327LctTctC11B.1.351.20.000303
ORF1ab/nsp3327L327delCTT---11B.1.360.000146
ORF1ab/nsp3327L327HcTtcAt11B.1.3670.000792
ORF1ab/nsp3327L327ICttAtt11B.1.3710.001122
ORF1ab/nsp3327L327LctTctC11B.1.4270.00005
ORF1ab/nsp3327L327delCTT---11B.1.4290.000024
ORF1ab/nsp3327L327ICttAtt11B.1.438.10.000107
ORF1ab/nsp3327L327FCttTtt11B.1.438.10.000107
ORF1ab/nsp3327L327LctTctG11B.1.438.10.000107
ORF1ab/nsp3327L327delCTT---11B.1.438.10.000107
ORF1ab/nsp3327L327FCttTtt11B.1.4800.002488
ORF1ab/nsp3327L327FCttTtt11B.1.5240.001406
ORF1ab/nsp3327L327FCttTtt11B.1.5250.000113
ORF1ab/nsp3327L327LctTctC11B.1.5680.001111
ORF1ab/nsp3327L327LctTctC11B.1.5870.001898
ORF1ab/nsp3327L327FCttTtt11B.1.5900.004545
ORF1ab/nsp3327L327SCTTTCG11B.1.617.20.000004
ORF1ab/nsp3327L327FCttTtt11B.1.6210.000089
ORF1ab/nsp3327L327LctTctA11B.1.6210.000089
ORF1ab/nsp3327L327delCTT---11B.1.6270.00202
ORF1ab/nsp3327L327FCttTtt11B.1.6320.006711
ORF1ab/nsp3327L327RcTtcGt11B.1.6370.000073
ORF1ab/nsp3327L327ICttAtt11B.1.6370.000073
ORF1ab/nsp3327L327LctTctG11B.1.6370.000073
ORF1ab/nsp3327L327delCTT---11B.570.015152
ORF1ab/nsp3327L327FCttTtt11C.36.3.10.002717
ORF1ab/nsp3327L327FCttTtt11C.370.000116
ORF1ab/nsp3327L327FCttTtt11C.80.004464
ORF1ab/nsp3327L327PcTtcCt11D.20.000075
ORF1ab/nsp3327L327LctTctA11D.20.000075
ORF1ab/nsp3327L327ICttAtt11P.10.000016
ORF1ab/nsp3327L327del1Ctt-tt11P.10.000016
ORF1ab/nsp3327L327delCTT---11P.1.10.000318
ORF1ab/nsp3327L327delCTT---11P.1.130.000898
ORF1ab/nsp3327L327FCttTtt11P.1.140.000048
ORF1ab/nsp3327L327FCttTtt11P.1.150.000232
ORF1ab/nsp3327L327PcTtcCt11P.1.150.000232
ORF1ab/nsp3327L327PcTtcCt11R.10.00009
ORF1ab/nsp3327L327FCttTtt11R.10.00009