CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = V577F

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2577V577FV757FnonsynGtcTtc170116960.9970612534-2536
ORF1ab/nsp2577V577FV757FnonsynGtCTtT170150.002939452534-2536

Details of the mutation V577F within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2577V577FGtcTtc16961701All0.000324
ORF1ab/nsp2577V577FGtCTtT51701All0.000001
ORF1ab/nsp2577V577FGtcTtc604604B.1.20.005318
ORF1ab/nsp2577V577FGtcTtc305306P.60.959119
ORF1ab/nsp2577V577FGtCTtT1306P.60.003145
ORF1ab/nsp2577V577FGtcTtc129129B.1.4080.476015
ORF1ab/nsp2577V577FGtcTtc8282AY.40.000128
ORF1ab/nsp2577V577FGtcTtc5959P.10.000929
ORF1ab/nsp2577V577FGtcTtc5353B.1.1.70.000047
ORF1ab/nsp2577V577FGtcTtc4040AY.430.000177
ORF1ab/nsp2577V577FGtcTtc3636B.1.617.20.000136
ORF1ab/nsp2577V577FGtcTtc3232B.10.000293
ORF1ab/nsp2577V577FGtcTtc2323B.1.1.2040.069909
ORF1ab/nsp2577V577FGtcTtc2222AY.290.000347
ORF1ab/nsp2577V577FGtcTtc1717AY.440.000103
ORF1ab/nsp2577V577FGtcTtc1616B.1.10.00029
ORF1ab/nsp2577V577FGtcTtc1515B.1.1.5190.000596
ORF1ab/nsp2577V577FGtcTtc1515B.1.1770.000198
ORF1ab/nsp2577V577FGtcTtc1414B.1.1.4340.00488
ORF1ab/nsp2577V577FGtcTtc1414P.1.17.10.012248
ORF1ab/nsp2577V577FGtcTtc1313AY.1030.000081
ORF1ab/nsp2577V577FGtcTtc1212B.1.2430.000835
ORF1ab/nsp2577V577FGtcTtc1111AY.250.000066
ORF1ab/nsp2577V577FGtcTtc1111P.1.10.003494
ORF1ab/nsp2577V577FGtcTtc1010B.1.1.280.003112
ORF1ab/nsp2577V577FGtcTtc77B.1.6210.00062
ORF1ab/nsp2577V577FGtcTtc66AY.1020.000159
ORF1ab/nsp2577V577FGtcTtc66AY.700.001251
ORF1ab/nsp2577V577FGtcTtc55AY.200.000194
ORF1ab/nsp2577V577FGtcTtc55AY.260.000142
ORF1ab/nsp2577V577FGtcTtc55AY.390.000124
ORF1ab/nsp2577V577FGtcTtc55AY.450.000608
ORF1ab/nsp2577V577FGtcTtc55AY.9.10.000419
ORF1ab/nsp2577V577FGtCTtT45AY.98.10.000194
ORF1ab/nsp2577V577FGtcTtc15AY.98.10.000048
ORF1ab/nsp2577V577FGtcTtc55B.1.360.00073
ORF1ab/nsp2577V577FGtcTtc55B.1.5250.000566
ORF1ab/nsp2577V577FGtcTtc44AY.1160.001147
ORF1ab/nsp2577V577FGtcTtc44AY.46.30.003735
ORF1ab/nsp2577V577FGtcTtc33AY.1000.000138
ORF1ab/nsp2577V577FGtcTtc33AY.230.000209
ORF1ab/nsp2577V577FGtcTtc33AY.30.00003
ORF1ab/nsp2577V577FGtcTtc33AY.460.000312
ORF1ab/nsp2577V577FGtcTtc33AY.46.60.000217
ORF1ab/nsp2577V577FGtcTtc33AY.9.20.00011
ORF1ab/nsp2577V577FGtcTtc33B.1.1.2140.000166
ORF1ab/nsp2577V577FGtcTtc33B.1.1.3170.001235
ORF1ab/nsp2577V577FGtcTtc33B.1.1990.012397
ORF1ab/nsp2577V577FGtcTtc33D.20.000225
ORF1ab/nsp2577V577FGtcTtc33P.1.140.000143
ORF1ab/nsp2577V577FGtcTtc22AY.1200.000074
ORF1ab/nsp2577V577FGtcTtc22AY.39.10.000079
ORF1ab/nsp2577V577FGtcTtc22AY.4.50.000215
ORF1ab/nsp2577V577FGtcTtc22AY.99.20.000184
ORF1ab/nsp2577V577FGtcTtc22B.1.1.3060.000877
ORF1ab/nsp2577V577FGtcTtc22B.1.160.70.004158
ORF1ab/nsp2577V577FGtcTtc22B.1.2340.000264
ORF1ab/nsp2577V577FGtcTtc22B.1.2400.000431
ORF1ab/nsp2577V577FGtcTtc22B.1.5260.000047
ORF1ab/nsp2577V577FGtcTtc22P.1.70.000639
ORF1ab/nsp2577V577FGtcTtc22P.70.008734
ORF1ab/nsp2577V577FGtcTtc11A.10.000282
ORF1ab/nsp2577V577FGtcTtc11A.160.016129
ORF1ab/nsp2577V577FGtcTtc11AJ.10.045455
ORF1ab/nsp2577V577FGtcTtc11AY.1080.001103
ORF1ab/nsp2577V577FGtcTtc11AY.1130.000142
ORF1ab/nsp2577V577FGtcTtc11AY.1140.000231
ORF1ab/nsp2577V577FGtcTtc11AY.120.20.001285
ORF1ab/nsp2577V577FGtcTtc11AY.130.000161
ORF1ab/nsp2577V577FGtcTtc11AY.160.00038
ORF1ab/nsp2577V577FGtcTtc11AY.330.000067
ORF1ab/nsp2577V577FGtcTtc11AY.340.000097
ORF1ab/nsp2577V577FGtcTtc11AY.34.10.00051
ORF1ab/nsp2577V577FGtcTtc11AY.420.00004
ORF1ab/nsp2577V577FGtcTtc11AY.46.40.000165
ORF1ab/nsp2577V577FGtcTtc11AY.7.10.000113
ORF1ab/nsp2577V577FGtcTtc11AY.740.000116
ORF1ab/nsp2577V577FGtcTtc11AY.750.000056
ORF1ab/nsp2577V577FGtcTtc11AY.90.000068
ORF1ab/nsp2577V577FGtcTtc11AY.910.00073
ORF1ab/nsp2577V577FGtcTtc11B0.000128
ORF1ab/nsp2577V577FGtcTtc11B.1.1.1130.006993
ORF1ab/nsp2577V577FGtcTtc11B.1.1.2310.003096
ORF1ab/nsp2577V577FGtcTtc11B.1.1.3480.000796
ORF1ab/nsp2577V577FGtcTtc11B.1.1.4580.041667
ORF1ab/nsp2577V577FGtcTtc11B.1.1.460.004367
ORF1ab/nsp2577V577FGtcTtc11B.1.1110.001175
ORF1ab/nsp2577V577FGtcTtc11B.1.130.002375
ORF1ab/nsp2577V577FGtcTtc11B.1.1470.000756
ORF1ab/nsp2577V577FGtcTtc11B.1.1600.000031
ORF1ab/nsp2577V577FGtcTtc11B.1.177.200.001517
ORF1ab/nsp2577V577FGtcTtc11B.1.177.570.000281
ORF1ab/nsp2577V577FGtcTtc11B.1.177.70.000165
ORF1ab/nsp2577V577FGtcTtc11B.1.2100.002132
ORF1ab/nsp2577V577FGtcTtc11B.1.3490.000715
ORF1ab/nsp2577V577FGtcTtc11B.1.36.350.002604
ORF1ab/nsp2577V577FGtcTtc11B.1.36.360.000602
ORF1ab/nsp2577V577FGtcTtc11B.1.36.390.002217
ORF1ab/nsp2577V577FGtcTtc11B.1.3960.000706
ORF1ab/nsp2577V577FGtcTtc11B.1.4290.000024
ORF1ab/nsp2577V577FGtcTtc11B.1.5170.000427
ORF1ab/nsp2577V577FGtcTtc11B.1.5950.000261
ORF1ab/nsp2577V577FGtcTtc11B.1.5960.000087
ORF1ab/nsp2577V577FGtcTtc11B.1.6090.000479
ORF1ab/nsp2577V577FGtcTtc11C.180.002591
ORF1ab/nsp2577V577FGtcTtc11P.30.001595

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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