CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = V381A

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2381V381AV561AnonsyngTtgCt12948129400.9993821946-1948
ORF1ab/nsp2381V381AV561AnonsyngTTgCA1294840.0003089281946-1948
ORF1ab/nsp2381V381AV561AnonsyngTTgCG1294830.0002316961946-1948
ORF1ab/nsp2381V381AV561AnonsyngTTgCC1294810.0000772321946-1948

Details of the mutation V381A within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2381V381AgTtgCt1294012948All0.002475
ORF1ab/nsp2381V381AgTTgCA412948All0.000001
ORF1ab/nsp2381V381AgTTgCG312948All0.000001
ORF1ab/nsp2381V381AgTTgCC112948All0
ORF1ab/nsp2381V381AgTtgCt37393739B.1.360.545521
ORF1ab/nsp2381V381AgTtgCt23552355B.1.36.180.989496
ORF1ab/nsp2381V381AgTtgCt19671967B.1.36.170.971838
ORF1ab/nsp2381V381AgTtgCt16541654B.1.36.360.995786
ORF1ab/nsp2381V381AgTtgCt794794B.1.36.270.606107
ORF1ab/nsp2381V381AgTtgCt603603B.1.36.380.990148
ORF1ab/nsp2381V381AgTtgCt428428B.1.36.390.949002
ORF1ab/nsp2381V381AgTtgCt359359B.1.36.370.997222
ORF1ab/nsp2381V381AgTtgCt305310B.10.002794
ORF1ab/nsp2381V381AgTTgCA3310B.10.000027
ORF1ab/nsp2381V381AgTTgCC1310B.10.000009
ORF1ab/nsp2381V381AgTTgCG1310B.10.000009
ORF1ab/nsp2381V381AgTtgCt173173B.1.36.280.994253
ORF1ab/nsp2381V381AgTtgCt9090B.1.36.20.967742
ORF1ab/nsp2381V381AgTtgCt8686B.1.36.220.103865
ORF1ab/nsp2381V381AgTtgCt4747B.1.36.80.047
ORF1ab/nsp2381V381AgTtgCt4747B.1.4560.153595
ORF1ab/nsp2381V381AgTtgCt2525B.1.36.100.119617
ORF1ab/nsp2381V381AgTtgCt2323B.1.10.000417
ORF1ab/nsp2381V381AgTtgCt1616B.1.2600.053512
ORF1ab/nsp2381V381AgTtgCt1414B.1.4250.041916
ORF1ab/nsp2381V381AgTtgCt1414B.1.4620.101449
ORF1ab/nsp2381V381AgTtgCt1313B.1.36.160.018519
ORF1ab/nsp2381V381AgTtgCt1212B.1.1.390.006116
ORF1ab/nsp2381V381AgTtgCt1010B.1.617.20.000038
ORF1ab/nsp2381V381AgTtgCt99B0.00115
ORF1ab/nsp2381V381AgTtgCt89B.1.1.70.000007
ORF1ab/nsp2381V381AgTTgCG19B.1.1.70.000001
ORF1ab/nsp2381V381AgTtgCt79B.1.1770.000092
ORF1ab/nsp2381V381AgTTgCG19B.1.1770.000013
ORF1ab/nsp2381V381AgTTgCA19B.1.1770.000013
ORF1ab/nsp2381V381AgTtgCt77B.1.1.5260.024823
ORF1ab/nsp2381V381AgTtgCt77B.1.36.310.012259
ORF1ab/nsp2381V381AgTtgCt66AY.30.00006
ORF1ab/nsp2381V381AgTtgCt66B.1.36.240.037037
ORF1ab/nsp2381V381AgTtgCt66B.1.4680.034286
ORF1ab/nsp2381V381AgTtgCt55AY.40.000008
ORF1ab/nsp2381V381AgTtgCt55B.1.20.000044
ORF1ab/nsp2381V381AgTtgCt55B.1.3510.000149
ORF1ab/nsp2381V381AgTtgCt55B.1.36.350.013021
ORF1ab/nsp2381V381AgTtgCt44AY.420.000161
ORF1ab/nsp2381V381AgTtgCt44AY.80.002424
ORF1ab/nsp2381V381AgTtgCt44B.1.4590.016327
ORF1ab/nsp2381V381AgTtgCt33AY.440.000018
ORF1ab/nsp2381V381AgTtgCt33B.1.2430.000209
ORF1ab/nsp2381V381AgTtgCt33B.1.5330.028846
ORF1ab/nsp2381V381AgTtgCt22AY.430.000009
ORF1ab/nsp2381V381AgTtgCt22AY.750.000112
ORF1ab/nsp2381V381AgTtgCt22AY.9.20.000073
ORF1ab/nsp2381V381AgTtgCt22B.1.1.5190.000079
ORF1ab/nsp2381V381AgTtgCt22B.1.36.190.018519
ORF1ab/nsp2381V381AgTtgCt22B.1.36.70.008
ORF1ab/nsp2381V381AgTtgCt22B.1.4530.006472
ORF1ab/nsp2381V381AgTtgCt22B.1.4700.002809
ORF1ab/nsp2381V381AgTtgCt22B.1.4740.003802
ORF1ab/nsp2381V381AgTtgCt22B.1.4800.004975
ORF1ab/nsp2381V381AgTtgCt22P.1.100.000539
ORF1ab/nsp2381V381AgTtgCt11AU.20.002421
ORF1ab/nsp2381V381AgTtgCt11AY.390.000025
ORF1ab/nsp2381V381AgTtgCt11AY.4.20.000022
ORF1ab/nsp2381V381AgTtgCt11AY.650.000533
ORF1ab/nsp2381V381AgTtgCt11AY.820.001357
ORF1ab/nsp2381V381AgTtgCt11AY.90.000068
ORF1ab/nsp2381V381AgTtgCt11B.1.1.1890.001513
ORF1ab/nsp2381V381AgTtgCt11B.1.1.280.000311
ORF1ab/nsp2381V381AgTtgCt11B.1.1.2910.000742
ORF1ab/nsp2381V381AgTtgCt11B.1.1.3060.000438
ORF1ab/nsp2381V381AgTtgCt11B.1.1.3490.010309
ORF1ab/nsp2381V381AgTtgCt11B.1.1180.006711
ORF1ab/nsp2381V381AgTtgCt11B.1.1390.000733
ORF1ab/nsp2381V381AgTtgCt11B.1.1600.000031
ORF1ab/nsp2381V381AgTtgCt11B.1.1640.014925
ORF1ab/nsp2381V381AgTtgCt11B.1.177.40.000211
ORF1ab/nsp2381V381AgTtgCt11B.1.177.560.000668
ORF1ab/nsp2381V381AgTtgCt11B.1.177.70.000165
ORF1ab/nsp2381V381AgTtgCt11B.1.177.860.000183
ORF1ab/nsp2381V381AgTtgCt11B.1.2100.002132
ORF1ab/nsp2381V381AgTtgCt11B.1.2210.000071
ORF1ab/nsp2381V381AgTtgCt11B.1.2790.000514
ORF1ab/nsp2381V381AgTtgCt11B.1.3110.000275
ORF1ab/nsp2381V381AgTtgCt11B.1.3360.002439
ORF1ab/nsp2381V381AgTtgCt11B.1.36.10.00114
ORF1ab/nsp2381V381AgTtgCt11B.1.36.290.000517
ORF1ab/nsp2381V381AgTtgCt11B.1.36.330.007576
ORF1ab/nsp2381V381AgTtgCt11B.1.36.340.021277
ORF1ab/nsp2381V381AgTtgCt11B.1.36.90.003215
ORF1ab/nsp2381V381AgTtgCt11B.1.3710.001122
ORF1ab/nsp2381V381AgTtgCt11B.1.3960.000706
ORF1ab/nsp2381V381AgTtgCt11B.1.4220.000812
ORF1ab/nsp2381V381AgTtgCt11B.1.438.10.000107
ORF1ab/nsp2381V381AgTtgCt11B.1.4420.035714
ORF1ab/nsp2381V381AgTtgCt11B.1.4630.008065
ORF1ab/nsp2381V381AgTtgCt11B.1.4650.003802
ORF1ab/nsp2381V381AgTtgCt11B.1.4690.00361
ORF1ab/nsp2381V381AgTtgCt11B.1.5230.002451
ORF1ab/nsp2381V381AgTtgCt11B.1.5260.000024
ORF1ab/nsp2381V381AgTtgCt11B.1.5960.000087
ORF1ab/nsp2381V381AgTtgCt11B.1.6290.013333
ORF1ab/nsp2381V381AgTtgCt11B.1.6370.000073
ORF1ab/nsp2381V381AgTtgCt11B.4.10.018868
ORF1ab/nsp2381V381AgTtgCt11C.370.000116
ORF1ab/nsp2381V381AgTtgCt11D.20.000075
ORF1ab/nsp2381V381AgTtgCt11P.10.000016
ORF1ab/nsp2381V381AgTtgCt11P.1.140.000048

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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