CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = P106L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2106P106LP286LnonsyncCacTa159115860.9968571121-1123
ORF1ab/nsp2106P106LP286LnonsynCCaTTa159130.001885611121-1123
ORF1ab/nsp2106P106LP286LnonsyncCAcTT159120.001257071121-1123

Details of the mutation P106L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2106P106LcCacTa15861591All0.000303
ORF1ab/nsp2106P106LCCaTTa31591All0.000001
ORF1ab/nsp2106P106LcCAcTT21591All0
ORF1ab/nsp2106P106LcCacTa599599A.270.991722
ORF1ab/nsp2106P106LcCacTa463463B.1.36.211
ORF1ab/nsp2106P106LcCacTa7272AY.40.000112
ORF1ab/nsp2106P106LcCacTa5858B.1.1.70.000052
ORF1ab/nsp2106P106LcCacTa3232AY.99.20.002949
ORF1ab/nsp2106P106LcCacTa2828AY.250.000168
ORF1ab/nsp2106P106LcCacTa2728B.1.617.20.000102
ORF1ab/nsp2106P106LCCaTTa128B.1.617.20.000004
ORF1ab/nsp2106P106LcCacTa2323AY.98.10.001114
ORF1ab/nsp2106P106LcCacTa2222B.1.4290.000518
ORF1ab/nsp2106P106LcCacTa2121B.10.000192
ORF1ab/nsp2106P106LcCacTa1414AY.200.000544
ORF1ab/nsp2106P106LcCacTa1314AY.440.000079
ORF1ab/nsp2106P106LcCAcTT114AY.440.000006
ORF1ab/nsp2106P106LcCacTa1414B.1.1770.000184
ORF1ab/nsp2106P106LcCacTa1313A0.005031
ORF1ab/nsp2106P106LcCacTa1212AY.430.000053
ORF1ab/nsp2106P106LcCacTa1010B.1.1.5170.068027
ORF1ab/nsp2106P106LcCacTa1010B.1.1.5190.000397
ORF1ab/nsp2106P106LcCacTa99AZ.10.007806
ORF1ab/nsp2106P106LcCacTa88B0.001022
ORF1ab/nsp2106P106LcCacTa88C.1.20.034043
ORF1ab/nsp2106P106LcCacTa88P.10.000126
ORF1ab/nsp2106P106LcCacTa77AY.390.000173
ORF1ab/nsp2106P106LcCacTa77AY.640.004167
ORF1ab/nsp2106P106LcCacTa77B.1.20.000062
ORF1ab/nsp2106P106LcCacTa77B.1.6210.00062
ORF1ab/nsp2106P106LcCacTa55AY.30.00005
ORF1ab/nsp2106P106LcCacTa55B.1.5580.022831
ORF1ab/nsp2106P106LcCacTa44AY.1030.000025
ORF1ab/nsp2106P106LcCacTa44B.1.1600.000125
ORF1ab/nsp2106P106LcCacTa33A.290.015957
ORF1ab/nsp2106P106LcCacTa33AY.1190.000106
ORF1ab/nsp2106P106LcCacTa33AY.300.001187
ORF1ab/nsp2106P106LcCacTa33B.1.10.000054
ORF1ab/nsp2106P106LcCacTa33B.1.2210.000213
ORF1ab/nsp2106P106LcCacTa33B.1.3960.002117
ORF1ab/nsp2106P106LcCacTa33B.1.4200.03125
ORF1ab/nsp2106P106LCCaTTa220.111111
ORF1ab/nsp2106P106LcCacTa22AY.1020.000053
ORF1ab/nsp2106P106LcCacTa22AY.260.000057
ORF1ab/nsp2106P106LcCacTa22AY.39.10.000079
ORF1ab/nsp2106P106LcCacTa22AY.4.50.000215
ORF1ab/nsp2106P106LcCacTa22AY.420.00008
ORF1ab/nsp2106P106LcCacTa22AY.5.30.000675
ORF1ab/nsp2106P106LcCacTa22B.1.1.1410.004024
ORF1ab/nsp2106P106LcCacTa22B.1.1.2140.000111
ORF1ab/nsp2106P106LcCacTa22B.1.2320.001075
ORF1ab/nsp2106P106LcCacTa22B.1.2580.000133
ORF1ab/nsp2106P106LcCacTa22B.1.3670.001585
ORF1ab/nsp2106P106LcCacTa22B.1.5260.000047
ORF1ab/nsp2106P106LcCacTa22C.360.001821
ORF1ab/nsp2106P106LcCacTa22C.36.3.10.005435
ORF1ab/nsp2106P106LcCacTa11A.10.000282
ORF1ab/nsp2106P106LcCacTa11A.20.000662
ORF1ab/nsp2106P106LcCacTa11AY.10.000396
ORF1ab/nsp2106P106LcCacTa11AY.1200.000037
ORF1ab/nsp2106P106LcCacTa11AY.1210.000135
ORF1ab/nsp2106P106LcCacTa11AY.130.000161
ORF1ab/nsp2106P106LcCacTa11AY.450.000122
ORF1ab/nsp2106P106LcCacTa11AY.460.000104
ORF1ab/nsp2106P106LcCacTa11AY.540.000095
ORF1ab/nsp2106P106LcCAcTT11AY.990.001049
ORF1ab/nsp2106P106LcCacTa11B.1.1.1610.003534
ORF1ab/nsp2106P106LcCacTa11B.1.1.250.000569
ORF1ab/nsp2106P106LcCacTa11B.1.1.2860.002899
ORF1ab/nsp2106P106LcCacTa11B.1.1.3010.001179
ORF1ab/nsp2106P106LcCacTa11B.1.1.3170.000412
ORF1ab/nsp2106P106LcCacTa11B.1.160.330.004425
ORF1ab/nsp2106P106LcCacTa11B.1.2650.001271
ORF1ab/nsp2106P106LcCacTa11B.1.2800.007143
ORF1ab/nsp2106P106LcCacTa11B.1.3510.00003
ORF1ab/nsp2106P106LcCacTa11B.1.3690.000285
ORF1ab/nsp2106P106LcCacTa11B.1.4270.00005
ORF1ab/nsp2106P106LcCacTa11B.1.5640.000426
ORF1ab/nsp2106P106LcCacTa11B.1.5960.000087
ORF1ab/nsp2106P106LcCacTa11B.550.00295
ORF1ab/nsp2106P106LcCacTa11B.60.00091
ORF1ab/nsp2106P106LcCacTa11C.10.002392
ORF1ab/nsp2106P106LcCacTa11C.140.004329
ORF1ab/nsp2106P106LcCacTa11C.60.037037

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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