CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = L578L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2578L578LL758LsynttGttA8875350.6031572537-2539
ORF1ab/nsp2578L578LL758LsynTtgCtg8873480.3923342537-2539
ORF1ab/nsp2578L578LL758LsynTtGCtA88740.004509582537-2539

Details of the mutation L578L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2578L578LttGttA535887All0.000102
ORF1ab/nsp2578L578LTtgCtg348887All0.000067
ORF1ab/nsp2578L578LTtGCtA4887All0.000001
ORF1ab/nsp2578L578LttGttA252252AY.60.010364
ORF1ab/nsp2578L578LttGttA139154B.1.1.70.000124
ORF1ab/nsp2578L578LTtgCtg15154B.1.1.70.000013
ORF1ab/nsp2578L578LTtgCtg150150AY.9.20.005509
ORF1ab/nsp2578L578LTtgCtg3646AY.40.000056
ORF1ab/nsp2578L578LttGttA1046AY.40.000016
ORF1ab/nsp2578L578LTtgCtg2637B.1.617.20.000098
ORF1ab/nsp2578L578LttGttA1037B.1.617.20.000038
ORF1ab/nsp2578L578LTtGCtA137B.1.617.20.000004
ORF1ab/nsp2578L578LTtgCtg2525N.20.961538
ORF1ab/nsp2578L578LttGttA1117B.1.20.000097
ORF1ab/nsp2578L578LTtgCtg617B.1.20.000053
ORF1ab/nsp2578L578LttGttA1116AY.1030.000068
ORF1ab/nsp2578L578LTtgCtg516AY.1030.000031
ORF1ab/nsp2578L578LTtgCtg816AY.430.000035
ORF1ab/nsp2578L578LttGttA816AY.430.000035
ORF1ab/nsp2578L578LTtgCtg711AY.1020.000186
ORF1ab/nsp2578L578LttGttA411AY.1020.000106
ORF1ab/nsp2578L578LttGttA1010P.1.140.000478
ORF1ab/nsp2578L578LTtgCtg69AY.250.000036
ORF1ab/nsp2578L578LttGttA39AY.250.000018
ORF1ab/nsp2578L578LttGttA48AY.390.000099
ORF1ab/nsp2578L578LTtgCtg48AY.390.000099
ORF1ab/nsp2578L578LTtgCtg77B.1.1600.000218
ORF1ab/nsp2578L578LTtgCtg47P.10.000063
ORF1ab/nsp2578L578LttGttA37P.10.000047
ORF1ab/nsp2578L578LttGttA36B.10.000027
ORF1ab/nsp2578L578LTtgCtg36B.10.000027
ORF1ab/nsp2578L578LttGttA46B.1.10.000073
ORF1ab/nsp2578L578LTtgCtg26B.1.10.000036
ORF1ab/nsp2578L578LttGttA55AY.1180.000313
ORF1ab/nsp2578L578LttGttA45AY.230.000279
ORF1ab/nsp2578L578LTtgCtg15AY.230.00007
ORF1ab/nsp2578L578LTtgCtg45B.1.1770.000053
ORF1ab/nsp2578L578LttGttA15B.1.1770.000013
ORF1ab/nsp2578L578LttGttA44AY.110.005355
ORF1ab/nsp2578L578LttGttA44AY.30.00004
ORF1ab/nsp2578L578LTtgCtg34AY.440.000018
ORF1ab/nsp2578L578LttGttA14AY.440.000006
ORF1ab/nsp2578L578LTtgCtg44AY.520.003257
ORF1ab/nsp2578L578LTtgCtg33AY.340.000291
ORF1ab/nsp2578L578LttGttA33AY.50.000062
ORF1ab/nsp2578L578LTtgCtg33B.1.1.330.001263
ORF1ab/nsp2578L578LTtgCtg23B.1.2400.000431
ORF1ab/nsp2578L578LttGttA13B.1.2400.000216
ORF1ab/nsp2578L578LTtgCtg23B.1.3510.000059
ORF1ab/nsp2578L578LttGttA13B.1.3510.00003
ORF1ab/nsp2578L578LttGttA33B.1.5680.003333
ORF1ab/nsp2578L578LttGttA33D.20.000225
ORF1ab/nsp2578L578LttGttA12AY.1010.00049
ORF1ab/nsp2578L578LTtGCtA12AY.1010.00049
ORF1ab/nsp2578L578LttGttA12AY.360.000148
ORF1ab/nsp2578L578LTtgCtg12AY.360.000148
ORF1ab/nsp2578L578LTtgCtg22AY.460.000208
ORF1ab/nsp2578L578LTtgCtg22AY.46.40.000329
ORF1ab/nsp2578L578LttGttA22B.1.5880.00182
ORF1ab/nsp2578L578LttGttA22Q.10.000253
ORF1ab/nsp2578L578LttGttA22Q.40.00091
ORF1ab/nsp2578L578LttGttA11AY.1000.000046
ORF1ab/nsp2578L578LTtgCtg11AY.1170.000085
ORF1ab/nsp2578L578LTtgCtg11AY.1200.000037
ORF1ab/nsp2578L578LttGttA11AY.120.2.10.000498
ORF1ab/nsp2578L578LttGttA11AY.140.000088
ORF1ab/nsp2578L578LttGttA11AY.170.008197
ORF1ab/nsp2578L578LttGttA11AY.200.000039
ORF1ab/nsp2578L578LTtgCtg11AY.260.000028
ORF1ab/nsp2578L578LTtgCtg11AY.3.10.000085
ORF1ab/nsp2578L578LttGttA11AY.300.000396
ORF1ab/nsp2578L578LTtgCtg11AY.310.018519
ORF1ab/nsp2578L578LttGttA11AY.39.10.00004
ORF1ab/nsp2578L578LttGttA11AY.420.00004
ORF1ab/nsp2578L578LttGttA11AY.46.60.000072
ORF1ab/nsp2578L578LttGttA11AY.470.000031
ORF1ab/nsp2578L578LTtGCtA11AY.550.000917
ORF1ab/nsp2578L578LTtgCtg11AY.570.000656
ORF1ab/nsp2578L578LTtGCtA11AY.610.000105
ORF1ab/nsp2578L578LttGttA11AY.690.000187
ORF1ab/nsp2578L578LTtgCtg11AY.710.000475
ORF1ab/nsp2578L578LTtgCtg11AY.780.001541
ORF1ab/nsp2578L578LttGttA11AY.90.000068
ORF1ab/nsp2578L578LttGttA11AY.9.10.000084
ORF1ab/nsp2578L578LttGttA11B0.000128
ORF1ab/nsp2578L578LttGttA11B.1.1.2050.003717
ORF1ab/nsp2578L578LttGttA11B.1.1.2220.000204
ORF1ab/nsp2578L578LTtgCtg11B.1.1.2630.001558
ORF1ab/nsp2578L578LttGttA11B.1.1.5190.00004
ORF1ab/nsp2578L578LttGttA11B.1.160.120.00641
ORF1ab/nsp2578L578LttGttA11B.1.177.540.000606
ORF1ab/nsp2578L578LttGttA11B.1.177.730.000566
ORF1ab/nsp2578L578LTtgCtg11B.1.1800.05
ORF1ab/nsp2578L578LTtgCtg11B.1.360.000146
ORF1ab/nsp2578L578LttGttA11B.1.36.100.004785
ORF1ab/nsp2578L578LttGttA11B.1.4290.000024
ORF1ab/nsp2578L578LTtgCtg11B.1.4670.04
ORF1ab/nsp2578L578LTtgCtg11B.1.5260.000024
ORF1ab/nsp2578L578LTtgCtg11B.1.5960.000087
ORF1ab/nsp2578L578LTtgCtg11B.1.6210.000089
ORF1ab/nsp2578L578LTtgCtg11B.1.6370.000073
ORF1ab/nsp2578L578LttGttA11B.30.000831
ORF1ab/nsp2578L578LttGttA11P.1.130.000898
ORF1ab/nsp2578L578LTtgCtg11P.60.003145
ORF1ab/nsp2578L578LttGttA11Q.80.000165

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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