CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = K489N

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2489K489NK669NnonsynaaGaaT847566330.7826552270-2272
ORF1ab/nsp2489K489NK669NnonsynaaGaaC847518420.2173452270-2272

Details of the mutation K489N within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2489K489NaaGaaT66338475All0.001269
ORF1ab/nsp2489K489NaaGaaC18428475All0.000352
ORF1ab/nsp2489K489NaaGaaT27492750AY.410.808054
ORF1ab/nsp2489K489NaaGaaC12750AY.410.000294
ORF1ab/nsp2489K489NaaGaaC16381638AY.10.648199
ORF1ab/nsp2489K489NaaGaaT9721013B.1.617.20.00366
ORF1ab/nsp2489K489NaaGaaC411013B.1.617.20.000154
ORF1ab/nsp2489K489NaaGaaT583592B.1.1.70.000522
ORF1ab/nsp2489K489NaaGaaC9592B.1.1.70.000008
ORF1ab/nsp2489K489NaaGaaT538538AY.1110.098535
ORF1ab/nsp2489K489NaaGaaT377379AY.430.00167
ORF1ab/nsp2489K489NaaGaaC2379AY.430.000009
ORF1ab/nsp2489K489NaaGaaT200205AY.250.001203
ORF1ab/nsp2489K489NaaGaaC5205AY.250.00003
ORF1ab/nsp2489K489NaaGaaT171173AY.1020.004534
ORF1ab/nsp2489K489NaaGaaC2173AY.1020.000053
ORF1ab/nsp2489K489NaaGaaT119120AY.440.000724
ORF1ab/nsp2489K489NaaGaaC1120AY.440.000006
ORF1ab/nsp2489K489NaaGaaT98100AY.40.000153
ORF1ab/nsp2489K489NaaGaaC2100AY.40.000003
ORF1ab/nsp2489K489NaaGaaT9092AY.1030.000559
ORF1ab/nsp2489K489NaaGaaC292AY.1030.000012
ORF1ab/nsp2489K489NaaGaaT6868B.1.1770.000895
ORF1ab/nsp2489K489NaaGaaT5656B.1.1.1760.024605
ORF1ab/nsp2489K489NaaGaaT5252B.1.2580.00346
ORF1ab/nsp2489K489NaaGaaC3439AY.1170.002874
ORF1ab/nsp2489K489NaaGaaT539AY.1170.000423
ORF1ab/nsp2489K489NaaGaaC3737AY.690.006907
ORF1ab/nsp2489K489NaaGaaT2432AY.390.000593
ORF1ab/nsp2489K489NaaGaaC832AY.390.000198
ORF1ab/nsp2489K489NaaGaaT2425AY.840.010499
ORF1ab/nsp2489K489NaaGaaC125AY.840.000437
ORF1ab/nsp2489K489NaaGaaT2525P.10.000394
ORF1ab/nsp2489K489NaaGaaT2323B.1.20.000203
ORF1ab/nsp2489K489NaaGaaT2021B.10.000183
ORF1ab/nsp2489K489NaaGaaC121B.10.000009
ORF1ab/nsp2489K489NaaGaaT1418AY.460.001457
ORF1ab/nsp2489K489NaaGaaC418AY.460.000416
ORF1ab/nsp2489K489NaaGaaC1016AY.330.000668
ORF1ab/nsp2489K489NaaGaaT616AY.330.000401
ORF1ab/nsp2489K489NaaGaaT1616P.1.140.000765
ORF1ab/nsp2489K489NaaGaaT1313AY.60.000535
ORF1ab/nsp2489K489NaaGaaT1313B.1.1.5190.000516
ORF1ab/nsp2489K489NaaGaaT1313B.1.2410.010552
ORF1ab/nsp2489K489NaaGaaT1212AY.200.000466
ORF1ab/nsp2489K489NaaGaaT1011AY.50.000206
ORF1ab/nsp2489K489NaaGaaC111AY.50.000021
ORF1ab/nsp2489K489NaaGaaT1111Q.10.00139
ORF1ab/nsp2489K489NaaGaaT810AY.920.002298
ORF1ab/nsp2489K489NaaGaaC210AY.920.000575
ORF1ab/nsp2489K489NaaGaaT1010AY.98.10.000484
ORF1ab/nsp2489K489NaaGaaT1010B.1.258.120.07874
ORF1ab/nsp2489K489NaaGaaT99AY.340.000873
ORF1ab/nsp2489K489NaaGaaT99AY.830.015517
ORF1ab/nsp2489K489NaaGaaT99AY.880.007958
ORF1ab/nsp2489K489NaaGaaT89D.20.0006
ORF1ab/nsp2489K489NaaGaaC19D.20.000075
ORF1ab/nsp2489K489NaaGaaT99R.10.00081
ORF1ab/nsp2489K489NaaGaaC48AY.1180.000251
ORF1ab/nsp2489K489NaaGaaT48AY.1180.000251
ORF1ab/nsp2489K489NaaGaaT88B.1.617.30.023881
ORF1ab/nsp2489K489NaaGaaT77AY.1000.000322
ORF1ab/nsp2489K489NaaGaaT77AY.30.00007
ORF1ab/nsp2489K489NaaGaaT77AY.5.40.001937
ORF1ab/nsp2489K489NaaGaaT77Q.80.001154
ORF1ab/nsp2489K489NaaGaaT66AY.1190.000212
ORF1ab/nsp2489K489NaaGaaT56AY.230.000349
ORF1ab/nsp2489K489NaaGaaC16AY.230.00007
ORF1ab/nsp2489K489NaaGaaT66AY.290.000095
ORF1ab/nsp2489K489NaaGaaT46AY.450.000487
ORF1ab/nsp2489K489NaaGaaC26AY.450.000243
ORF1ab/nsp2489K489NaaGaaT66B.1.360.000875
ORF1ab/nsp2489K489NaaGaaT55A.2.50.002495
ORF1ab/nsp2489K489NaaGaaT55AY.380.002496
ORF1ab/nsp2489K489NaaGaaT55AY.46.10.005133
ORF1ab/nsp2489K489NaaGaaC45AY.620.001743
ORF1ab/nsp2489K489NaaGaaT15AY.620.000436
ORF1ab/nsp2489K489NaaGaaT35AY.750.000168
ORF1ab/nsp2489K489NaaGaaC25AY.750.000112
ORF1ab/nsp2489K489NaaGaaT55B.1.10.000091
ORF1ab/nsp2489K489NaaGaaT55B.1.3510.000149
ORF1ab/nsp2489K489NaaGaaT35B.1.5260.000071
ORF1ab/nsp2489K489NaaGaaC25B.1.5260.000047
ORF1ab/nsp2489K489NaaGaaT34AY.1130.000427
ORF1ab/nsp2489K489NaaGaaC14AY.1130.000142
ORF1ab/nsp2489K489NaaGaaT44AY.1160.001147
ORF1ab/nsp2489K489NaaGaaT34AY.120.000948
ORF1ab/nsp2489K489NaaGaaC14AY.120.000316
ORF1ab/nsp2489K489NaaGaaT34AY.1200.000112
ORF1ab/nsp2489K489NaaGaaC14AY.1200.000037
ORF1ab/nsp2489K489NaaGaaT24AY.260.000057
ORF1ab/nsp2489K489NaaGaaC24AY.260.000057
ORF1ab/nsp2489K489NaaGaaT34AY.34.10.00153
ORF1ab/nsp2489K489NaaGaaC14AY.34.10.00051
ORF1ab/nsp2489K489NaaGaaT44AY.360.000593
ORF1ab/nsp2489K489NaaGaaT34AY.5.30.001012
ORF1ab/nsp2489K489NaaGaaC14AY.5.30.000337
ORF1ab/nsp2489K489NaaGaaT34AY.540.000286
ORF1ab/nsp2489K489NaaGaaC14AY.540.000095
ORF1ab/nsp2489K489NaaGaaT34AY.670.001393
ORF1ab/nsp2489K489NaaGaaC14AY.670.000464
ORF1ab/nsp2489K489NaaGaaT44AY.740.000463
ORF1ab/nsp2489K489NaaGaaT44AY.770.00451
ORF1ab/nsp2489K489NaaGaaT44AY.890.019608
ORF1ab/nsp2489K489NaaGaaT44AY.99.20.000369
ORF1ab/nsp2489K489NaaGaaT44B.1.5960.000349
ORF1ab/nsp2489K489NaaGaaT33AY.1210.000406
ORF1ab/nsp2489K489NaaGaaT33AY.610.000314
ORF1ab/nsp2489K489NaaGaaT33B.1.1.2140.000166
ORF1ab/nsp2489K489NaaGaaT33B.1.1.2840.000322
ORF1ab/nsp2489K489NaaGaaT33B.1.1.3110.001074
ORF1ab/nsp2489K489NaaGaaT33B.1.36.180.001261
ORF1ab/nsp2489K489NaaGaaT33B.1.3670.002377
ORF1ab/nsp2489K489NaaGaaT33B.1.4090.002344
ORF1ab/nsp2489K489NaaGaaT33B.1.5700.008824
ORF1ab/nsp2489K489NaaGaaT33C.20.048387
ORF1ab/nsp2489K489NaaGaaT33P.1.170.000485
ORF1ab/nsp2489K489NaaGaaT33P.1.70.000958
ORF1ab/nsp2489K489NaaGaaT22AY.1080.002205
ORF1ab/nsp2489K489NaaGaaT22AY.120.20.002571
ORF1ab/nsp2489K489NaaGaaT12AY.130.000161
ORF1ab/nsp2489K489NaaGaaC12AY.130.000161
ORF1ab/nsp2489K489NaaGaaT22AY.3.10.000171
ORF1ab/nsp2489K489NaaGaaT22AY.420.00008
ORF1ab/nsp2489K489NaaGaaT22AY.46.40.000329
ORF1ab/nsp2489K489NaaGaaC12AY.470.000031
ORF1ab/nsp2489K489NaaGaaT12AY.470.000031
ORF1ab/nsp2489K489NaaGaaT22AY.590.001059
ORF1ab/nsp2489K489NaaGaaT22AY.650.001066
ORF1ab/nsp2489K489NaaGaaC12AY.730.000665
ORF1ab/nsp2489K489NaaGaaT12AY.730.000665
ORF1ab/nsp2489K489NaaGaaT22AY.9.20.000073
ORF1ab/nsp2489K489NaaGaaT22AZ.20.001642
ORF1ab/nsp2489K489NaaGaaT22B.1.1.2220.000408
ORF1ab/nsp2489K489NaaGaaT22B.1.1.3750.02381
ORF1ab/nsp2489K489NaaGaaT22B.1.1.390.001019
ORF1ab/nsp2489K489NaaGaaT22B.1.2400.000431
ORF1ab/nsp2489K489NaaGaaT22B.1.3690.00057
ORF1ab/nsp2489K489NaaGaaT22B.1.5650.001621
ORF1ab/nsp2489K489NaaGaaT22B.1.5750.000607
ORF1ab/nsp2489K489NaaGaaT22B.1.6210.000177
ORF1ab/nsp2489K489NaaGaaT22B.1.6370.000146
ORF1ab/nsp2489K489NaaGaaT22C.370.000232
ORF1ab/nsp2489K489NaaGaaT22P.20.000373
ORF1ab/nsp2489K489NaaGaaT110.055556
ORF1ab/nsp2489K489NaaGaaT11AD.20.000219
ORF1ab/nsp2489K489NaaGaaC11AY.1050.000643
ORF1ab/nsp2489K489NaaGaaC11AY.160.00038
ORF1ab/nsp2489K489NaaGaaT11AY.16.10.00047
ORF1ab/nsp2489K489NaaGaaC11AY.190.00114
ORF1ab/nsp2489K489NaaGaaC11AY.220.002092
ORF1ab/nsp2489K489NaaGaaT11AY.240.000431
ORF1ab/nsp2489K489NaaGaaT11AY.4.20.000022
ORF1ab/nsp2489K489NaaGaaC11AY.4.50.000107
ORF1ab/nsp2489K489NaaGaaT11AY.46.20.000635
ORF1ab/nsp2489K489NaaGaaC11AY.510.000909
ORF1ab/nsp2489K489NaaGaaC11AY.560.001605
ORF1ab/nsp2489K489NaaGaaT11AY.600.000938
ORF1ab/nsp2489K489NaaGaaT11AY.680.000274
ORF1ab/nsp2489K489NaaGaaT11AY.700.000209
ORF1ab/nsp2489K489NaaGaaT11AY.75.10.00018
ORF1ab/nsp2489K489NaaGaaC11AY.780.001541
ORF1ab/nsp2489K489NaaGaaC11AY.820.001357
ORF1ab/nsp2489K489NaaGaaC11AY.850.000427
ORF1ab/nsp2489K489NaaGaaC11AY.870.000833
ORF1ab/nsp2489K489NaaGaaT11AY.950.000761
ORF1ab/nsp2489K489NaaGaaC11AY.980.000079
ORF1ab/nsp2489K489NaaGaaT11B0.000128
ORF1ab/nsp2489K489NaaGaaT11B.1.1.2550.00303
ORF1ab/nsp2489K489NaaGaaT11B.1.1.3040.002809
ORF1ab/nsp2489K489NaaGaaT11B.1.1.3520.03125
ORF1ab/nsp2489K489NaaGaaT11B.1.110.30.000718
ORF1ab/nsp2489K489NaaGaaT11B.1.1600.000031
ORF1ab/nsp2489K489NaaGaaT11B.1.177.330.001645
ORF1ab/nsp2489K489NaaGaaT11B.1.177.570.000281
ORF1ab/nsp2489K489NaaGaaT11B.1.177.810.000189
ORF1ab/nsp2489K489NaaGaaC11B.1.2210.000071
ORF1ab/nsp2489K489NaaGaaT11B.1.2320.000537
ORF1ab/nsp2489K489NaaGaaT11B.1.2340.000132
ORF1ab/nsp2489K489NaaGaaT11B.1.36.290.000517
ORF1ab/nsp2489K489NaaGaaT11B.1.4280.00102
ORF1ab/nsp2489K489NaaGaaT11B.1.4970.000315
ORF1ab/nsp2489K489NaaGaaT11B.1.5230.002451
ORF1ab/nsp2489K489NaaGaaT11B.1.6090.000479
ORF1ab/nsp2489K489NaaGaaT11B.1.6250.002353
ORF1ab/nsp2489K489NaaGaaT11C.360.000911
ORF1ab/nsp2489K489NaaGaaT11C.60.037037

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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