CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = I251L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2251I251LI431LnonsynAtaTta66340.5151521556-1558
ORF1ab/nsp2251I251LI431LnonsynAtaCta66300.4545451556-1558
ORF1ab/nsp2251I251LI431LnonsynAtACtT6610.01515151556-1558
ORF1ab/nsp2251I251LI431LnonsynAtATtG6610.01515151556-1558

Details of the mutation I251L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2251I251LAtaTta3466All0.000007
ORF1ab/nsp2251I251LAtaCta3066All0.000006
ORF1ab/nsp2251I251LAtATtG166All0
ORF1ab/nsp2251I251LAtACtT166All0
ORF1ab/nsp2251I251LAtaCta1313AY.360.001927
ORF1ab/nsp2251I251LAtaTta99A.23.10.006338
ORF1ab/nsp2251I251LAtaCta77B.1.1.1380.042424
ORF1ab/nsp2251I251LAtaCta350.166667
ORF1ab/nsp2251I251LAtaTta250.111111
ORF1ab/nsp2251I251LAtaTta35AY.40.000005
ORF1ab/nsp2251I251LAtaCta25AY.40.000003
ORF1ab/nsp2251I251LAtaTta45B.1.1.70.000004
ORF1ab/nsp2251I251LAtACtT15B.1.1.70.000001
ORF1ab/nsp2251I251LAtaTta55P.10.000079
ORF1ab/nsp2251I251LAtaTta34B.10.000027
ORF1ab/nsp2251I251LAtaCta14B.10.000009
ORF1ab/nsp2251I251LAtaTta22B.1.5820.000981
ORF1ab/nsp2251I251LAtaTta22P.20.000373
ORF1ab/nsp2251I251LAtaCta11AY.16.10.00047
ORF1ab/nsp2251I251LAtaCta11AY.430.000004
ORF1ab/nsp2251I251LAtATtG11AY.440.000006
ORF1ab/nsp2251I251LAtaCta11B.1.1670.007812
ORF1ab/nsp2251I251LAtaCta11B.1.1770.000013
ORF1ab/nsp2251I251LAtaTta11B.1.20.000009
ORF1ab/nsp2251I251LAtaTta11B.1.3510.00003
ORF1ab/nsp2251I251LAtaTta11B.1.36.10.00114
ORF1ab/nsp2251I251LAtaTta11P.70.004367

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.