CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = F499L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2499F499LF679LnonsynTttCtt4634100.8855292300-2302
ORF1ab/nsp2499F499LF679LnonsynttTttA463350.0755942300-2302
ORF1ab/nsp2499F499LF679LnonsynttTttG463130.02807782300-2302
ORF1ab/nsp2499F499LF679LnonsynTtTCtG46330.006479482300-2302
ORF1ab/nsp2499F499LF679LnonsynTtTCtA46320.004319652300-2302

Details of the mutation F499L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2499F499LTttCtt410463All0.000078
ORF1ab/nsp2499F499LttTttA35463All0.000007
ORF1ab/nsp2499F499LttTttG13463All0.000002
ORF1ab/nsp2499F499LTtTCtG3463All0.000001
ORF1ab/nsp2499F499LTtTCtA2463All0
ORF1ab/nsp2499F499LTttCtt134136B.10.001227
ORF1ab/nsp2499F499LttTttA2136B.10.000018
ORF1ab/nsp2499F499LTttCtt6666AY.46.40.010857
ORF1ab/nsp2499F499LTttCtt5959B.1.5631
ORF1ab/nsp2499F499LttTttA2541B.1.617.20.000094
ORF1ab/nsp2499F499LTttCtt1341B.1.617.20.000049
ORF1ab/nsp2499F499LTtTCtA141B.1.617.20.000004
ORF1ab/nsp2499F499LttTttG141B.1.617.20.000004
ORF1ab/nsp2499F499LTtTCtG141B.1.617.20.000004
ORF1ab/nsp2499F499LTttCtt2323AY.40.000036
ORF1ab/nsp2499F499LTttCtt2222AY.1020.000583
ORF1ab/nsp2499F499LTttCtt1111AY.30.000109
ORF1ab/nsp2499F499LTttCtt810B.1.20.00007
ORF1ab/nsp2499F499LttTttG210B.1.20.000018
ORF1ab/nsp2499F499LTttCtt69AY.440.000037
ORF1ab/nsp2499F499LttTttG39AY.440.000018
ORF1ab/nsp2499F499LTttCtt77AY.98.10.000339
ORF1ab/nsp2499F499LTttCtt67B.1.1.70.000005
ORF1ab/nsp2499F499LttTttG17B.1.1.70.000001
ORF1ab/nsp2499F499LTttCtt66B.1.3620.009245
ORF1ab/nsp2499F499LTttCtt55AY.430.000022
ORF1ab/nsp2499F499LTttCtt35AY.9.20.00011
ORF1ab/nsp2499F499LTtTCtG25AY.9.20.000073
ORF1ab/nsp2499F499LTttCtt55P.10.000079
ORF1ab/nsp2499F499LTttCtt34B.1.10.000054
ORF1ab/nsp2499F499LttTttA14B.1.10.000018
ORF1ab/nsp2499F499LTttCtt33AY.1030.000019
ORF1ab/nsp2499F499LTttCtt33AY.260.000085
ORF1ab/nsp2499F499LTttCtt33AY.750.000168
ORF1ab/nsp2499F499LttTttA33N.50.0053
ORF1ab/nsp2499F499LTttCtt22AY.230.000139
ORF1ab/nsp2499F499LTttCtt22B.1.1.2160.001781
ORF1ab/nsp2499F499LTttCtt12B.1.258.170.000104
ORF1ab/nsp2499F499LttTttG12B.1.258.170.000104
ORF1ab/nsp2499F499LTttCtt12B.1.4270.00005
ORF1ab/nsp2499F499LttTttA12B.1.4270.00005
ORF1ab/nsp2499F499LTttCtt22D.20.00015
ORF1ab/nsp2499F499LttTttG11A0.000387
ORF1ab/nsp2499F499LTttCtt11A.2.40.003367
ORF1ab/nsp2499F499LTtTCtA11A.23.10.000704
ORF1ab/nsp2499F499LttTttA11AY.1000.000046
ORF1ab/nsp2499F499LTttCtt11AY.1200.000037
ORF1ab/nsp2499F499LttTttG11AY.120.10.000321
ORF1ab/nsp2499F499LttTttA11AY.250.000006
ORF1ab/nsp2499F499LTttCtt11AY.320.000532
ORF1ab/nsp2499F499LTttCtt11AY.330.000067
ORF1ab/nsp2499F499LTttCtt11AY.340.000097
ORF1ab/nsp2499F499LTttCtt11AY.34.10.00051
ORF1ab/nsp2499F499LTttCtt11AY.420.00004
ORF1ab/nsp2499F499LttTttG11AY.460.000104
ORF1ab/nsp2499F499LTttCtt11B.1.1.1980.001468
ORF1ab/nsp2499F499LTttCtt11B.1.1.390.00051
ORF1ab/nsp2499F499LTttCtt11B.1.110.30.000718
ORF1ab/nsp2499F499LttTttG11B.1.177.230.003236
ORF1ab/nsp2499F499LttTttG11B.1.177.430.001477
ORF1ab/nsp2499F499LTttCtt11B.1.177.90.001332
ORF1ab/nsp2499F499LTttCtt11B.1.4040.001302
ORF1ab/nsp2499F499LttTttA11B.1.4290.000024
ORF1ab/nsp2499F499LTttCtt11B.1.438.10.000107
ORF1ab/nsp2499F499LTttCtt11B.1.5200.021739
ORF1ab/nsp2499F499LTttCtt11B.1.6200.000946
ORF1ab/nsp2499F499LTttCtt11C.230.005814

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.