CoV-GLUEGenomeCountriesLineagesMutationsInsertionsDeletionsUpdated:

CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = F356L

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp2356F356LF536LnonsynTttCtt252421540.8534071871-1873
ORF1ab/nsp2356F356LF536LnonsynttTttA25243350.1327261871-1873
ORF1ab/nsp2356F356LF536LnonsynttTttG2524350.01386691871-1873

Details of the mutation F356L within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp2356F356LTttCtt21542524All0.000412
ORF1ab/nsp2356F356LttTttA3352524All0.000064
ORF1ab/nsp2356F356LttTttG352524All0.000007
ORF1ab/nsp2356F356LTttCtt11061106AY.910.807889
ORF1ab/nsp2356F356LTttCtt574578AY.40.000893
ORF1ab/nsp2356F356LttTttG3578AY.40.000005
ORF1ab/nsp2356F356LttTttA1578AY.40.000002
ORF1ab/nsp2356F356LttTttA288288AY.750.016134
ORF1ab/nsp2356F356LTttCtt243243AY.91.10.987805
ORF1ab/nsp2356F356LTttCtt3341B.1.617.20.000124
ORF1ab/nsp2356F356LttTttG441B.1.617.20.000015
ORF1ab/nsp2356F356LttTttA441B.1.617.20.000015
ORF1ab/nsp2356F356LTttCtt3235B.1.1.70.000029
ORF1ab/nsp2356F356LttTttA335B.1.1.70.000003
ORF1ab/nsp2356F356LTttCtt2222AY.1020.000583
ORF1ab/nsp2356F356LTttCtt2020AY.390.000494
ORF1ab/nsp2356F356LttTttA613AY.1030.000037
ORF1ab/nsp2356F356LTttCtt413AY.1030.000025
ORF1ab/nsp2356F356LttTttG313AY.1030.000019
ORF1ab/nsp2356F356LttTttA1113B.1.6090.005273
ORF1ab/nsp2356F356LttTttG213B.1.6090.000959
ORF1ab/nsp2356F356LttTttA1012B.1.10.000181
ORF1ab/nsp2356F356LTttCtt212B.1.10.000036
ORF1ab/nsp2356F356LTttCtt1111B.1.1.2140.00061
ORF1ab/nsp2356F356LTttCtt1111B.1.2580.000732
ORF1ab/nsp2356F356LttTttA99R.10.00081
ORF1ab/nsp2356F356LTttCtt88AY.5.30.002699
ORF1ab/nsp2356F356LTttCtt77AY.50.000145
ORF1ab/nsp2356F356LttTttG47B.10.000037
ORF1ab/nsp2356F356LTttCtt37B.10.000027
ORF1ab/nsp2356F356LttTttG66AY.1210.000812
ORF1ab/nsp2356F356LTttCtt55AY.430.000022
ORF1ab/nsp2356F356LTttCtt45AY.440.000024
ORF1ab/nsp2356F356LttTttA15AY.440.000006
ORF1ab/nsp2356F356LTttCtt55AY.550.004587
ORF1ab/nsp2356F356LTttCtt44AY.30.00004
ORF1ab/nsp2356F356LTttCtt44AY.450.000487
ORF1ab/nsp2356F356LttTttG44B.1.1.2070.004728
ORF1ab/nsp2356F356LTttCtt34P.10.000047
ORF1ab/nsp2356F356LttTttG14P.10.000016
ORF1ab/nsp2356F356LTttCtt33AY.290.000047
ORF1ab/nsp2356F356LTttCtt33AY.420.000121
ORF1ab/nsp2356F356LTttCtt33B.1.2430.000209
ORF1ab/nsp2356F356LttTttG22A0.000774
ORF1ab/nsp2356F356LTttCtt22AY.160.000759
ORF1ab/nsp2356F356LTttCtt22AY.250.000012
ORF1ab/nsp2356F356LTttCtt22AY.4.30.001684
ORF1ab/nsp2356F356LTttCtt22AY.580.001815
ORF1ab/nsp2356F356LTttCtt22AY.610.00021
ORF1ab/nsp2356F356LTttCtt22AY.840.000875
ORF1ab/nsp2356F356LTttCtt22B.1.160.250.022222
ORF1ab/nsp2356F356LTttCtt22B.1.177.160.001329
ORF1ab/nsp2356F356LttTttG12B.1.20.000009
ORF1ab/nsp2356F356LTttCtt12B.1.20.000009
ORF1ab/nsp2356F356LttTttG11AY.10.000396
ORF1ab/nsp2356F356LTttCtt11AY.1000.000046
ORF1ab/nsp2356F356LTttCtt11AY.1050.000643
ORF1ab/nsp2356F356LTttCtt11AY.1180.000063
ORF1ab/nsp2356F356LTttCtt11AY.140.000088
ORF1ab/nsp2356F356LTttCtt11AY.170.008197
ORF1ab/nsp2356F356LTttCtt11AY.39.10.00004
ORF1ab/nsp2356F356LTttCtt11AY.480.000465
ORF1ab/nsp2356F356LttTttA11AY.520.000814
ORF1ab/nsp2356F356LTttCtt11AY.620.000436
ORF1ab/nsp2356F356LTttCtt11AY.75.10.00018
ORF1ab/nsp2356F356LTttCtt11AY.780.001541
ORF1ab/nsp2356F356LTttCtt11AY.850.000427
ORF1ab/nsp2356F356LTttCtt11AY.920.000287
ORF1ab/nsp2356F356LTttCtt11AY.950.000761
ORF1ab/nsp2356F356LTttCtt11AY.960.002075
ORF1ab/nsp2356F356LttTttG11AY.980.000079
ORF1ab/nsp2356F356LttTttG11B.1.1.2220.000204
ORF1ab/nsp2356F356LTttCtt11B.1.1.280.000311
ORF1ab/nsp2356F356LTttCtt11B.1.1.2840.000107
ORF1ab/nsp2356F356LttTttG11B.1.1.4020.011111
ORF1ab/nsp2356F356LTttCtt11B.1.1.4090.002833
ORF1ab/nsp2356F356LTttCtt11B.1.1600.000031
ORF1ab/nsp2356F356LTttCtt11B.1.160.260.002421
ORF1ab/nsp2356F356LTttCtt11B.1.214.20.0006
ORF1ab/nsp2356F356LTttCtt11B.1.2410.000812
ORF1ab/nsp2356F356LTttCtt11B.1.258.170.000104
ORF1ab/nsp2356F356LTttCtt11B.1.3510.00003
ORF1ab/nsp2356F356LTttCtt11B.1.36.170.000494
ORF1ab/nsp2356F356LTttCtt11B.1.4290.000024
ORF1ab/nsp2356F356LTttCtt11B.1.4560.003268
ORF1ab/nsp2356F356LttTttG11B.1.5090.000866
ORF1ab/nsp2356F356LttTttA11B.1.6280.000352
ORF1ab/nsp2356F356LTttCtt11B.60.00091

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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