CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : Mut = E442X

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp2	442	E442X	E622X	nonsyn	Gaa	Taa	13	11	0.846154	2129-2131
ORF1ab/nsp2	442	E442X	E622X	nonsyn	GAa	TGa	13	2	0.153846	2129-2131

Details of the mutation E442X within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp2	442	E442X	Gaa	Taa	11	13	All	0.000002
ORF1ab/nsp2	442	E442X	GAa	TGa	2	13	All	0
ORF1ab/nsp2	442	E442X	Gaa	Taa	2	3		0.111111
ORF1ab/nsp2	442	E442X	GAa	TGa	1	3		0.055556
ORF1ab/nsp2	442	E442X	Gaa	Taa	3	3	B.1	0.000027
ORF1ab/nsp2	442	E442X	GAa	TGa	1	2	B.1.1	0.000018
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	2	B.1.1	0.000018
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	1	AY.26	0.000028
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	1	AY.92	0.000287
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	1	B	0.000128
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	1	B.41	0.008
ORF1ab/nsp2	442	E442X	Gaa	Taa	1	1	B.6.6	0.000889

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.