CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : CodonNum = 256 & Codon = acG
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp2 | 256 | T256T | T436T | syn | acA | acG | 928 | 659 | 0.710129 | 1571-1573 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 659 | 928 | All | 0.000126 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 229 | 248 | B.1.1.7 | 0.000205 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 6 | 111 | B.1.1 | 0.000109 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 58 | 74 | P.1 | 0.000914 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 34 | 42 | AY.43 | 0.000151 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 24 | 25 | AY.103 | 0.000149 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 17 | 25 | AY.4 | 0.000026 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 17 | 25 | B.1.617.2 | 0.000064 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 10 | 24 | B.1 | 0.000092 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 21 | 21 | AY.98.1 | 0.001017 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 20 | 20 | AY.25 | 0.00012 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 16 | 20 | AY.44 | 0.000097 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 15 | 16 | B.1.1.231 | 0.04644 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 14 | 14 | AY.14 | 0.001232 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 13 | 13 | AY.1 | 0.005144 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 9 | 13 | AY.46 | 0.000937 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 9 | 11 | AY.20 | 0.00035 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 5 | 11 | B.1.2 | 0.000044 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 7 | 9 | AY.5 | 0.000145 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 8 | 8 | AY.5.4 | 0.002214 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 6 | 8 | P.1.14 | 0.000287 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 6 | 7 | AY.3 | 0.00006 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 7 | 7 | B.1.234 | 0.000924 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 6 | 0.055556 | |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 6 | 6 | AY.39 | 0.000148 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 5 | 6 | B.1.177 | 0.000066 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 4 | 5 | B.1.427 | 0.000202 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 5 | Q.3 | 0.000145 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 4 | B.1.1.70 | 0.001023 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 4 | B.1.160 | 0.000094 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 4 | B.1.429 | 0.000071 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 3 | AY.100 | 0.000092 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 3 | AY.102 | 0.000027 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 3 | AY.118 | 0.000188 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 3 | B.1.1.519 | 0.000119 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 3 | 3 | B.1.258.17 | 0.000312 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 3 | B.1.526 | 0.000024 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | AY.54 | 0.000191 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 2 | AY.7.2 | 0.000559 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 2 | AY.9.1 | 0.000084 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | B.1.1.306 | 0.000877 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | B.1.1.39 | 0.001019 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | B.1.630 | 0.010471 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | B.1.637 | 0.000146 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 2 | 2 | C.36.3 | 0.001134 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.119 | 0.000035 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.41 | 0.000294 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.46.2 | 0.000635 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.48 | 0.000465 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.75 | 0.000056 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | AY.92 | 0.000287 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.186 | 0.003436 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.25 | 0.000569 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.289 | 0.002083 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.318 | 0.000302 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.445 | 0.037037 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.1.63 | 0.000386 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.160.10 | 0.008065 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.177.43 | 0.001477 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.177.81 | 0.000189 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.243 | 0.00007 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.351.2 | 0.000303 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.36.29 | 0.000517 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.361 | 0.001289 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.396 | 0.000706 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.426 | 0.001009 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.462 | 0.007246 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.590 | 0.004545 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.1.628 | 0.000352 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.6 | 0.00091 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | B.6.6 | 0.000889 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | P.1.1 | 0.000318 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | P.1.17 | 0.000162 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | Q.8 | 0.000165 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | W.4 | 0.001351 |
| ORF1ab/nsp2 | 256 | T256T | acA | acG | 1 | 1 | Z.1 | 0.00289 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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