CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : CodonNum = 256 & Codon = Tca

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp2	256	T256S	T436S	nonsyn	Aca	Tca	70	33	0.471429	1571-1573

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp2	256	T256S	Aca	Tca	33	70	All	0.000006
ORF1ab/nsp2	256	T256S	Aca	Tca	10	24	P.1	0.000158
ORF1ab/nsp2	256	T256S	Aca	Tca	5	15	P.2	0.000933
ORF1ab/nsp2	256	T256S	Aca	Tca	3	8		0.166667
ORF1ab/nsp2	256	T256S	Aca	Tca	4	6	B.1	0.000037
ORF1ab/nsp2	256	T256S	Aca	Tca	2	4	P.7	0.008734
ORF1ab/nsp2	256	T256S	Aca	Tca	1	2	AY.99.2	0.000092
ORF1ab/nsp2	256	T256S	Aca	Tca	1	2	B.1.1.28	0.000311
ORF1ab/nsp2	256	T256S	Aca	Tca	2	2	B.1.351	0.000059
ORF1ab/nsp2	256	T256S	Aca	Tca	1	2	P.1.2	0.001156
ORF1ab/nsp2	256	T256S	Aca	Tca	1	1	AY.58	0.000907
ORF1ab/nsp2	256	T256S	Aca	Tca	1	1	B.1.1.7	0.000001
ORF1ab/nsp2	256	T256S	Aca	Tca	1	1	B.1.221	0.000071
ORF1ab/nsp2	256	T256S	Aca	Tca	1	1	B.1.526	0.000024

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.