CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp2 : CodonNum = 218 & Codon = cAt
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp2 | 218 | R218H | R398H | nonsyn | cGt | cAt | 580 | 577 | 0.994828 | 1457-1459 |
Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 577 | 580 | All | 0.00011 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 95 | 96 | B.1.1.7 | 0.000085 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 95 | 95 | AY.4 | 0.000148 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 58 | 58 | B.1.429 | 0.001365 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 49 | 49 | B.1.2 | 0.000431 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 34 | 34 | AY.43 | 0.000151 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 26 | 26 | B.1.617.2 | 0.000098 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 21 | 21 | AY.3 | 0.000209 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 17 | 17 | AY.44 | 0.000103 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 11 | 11 | AY.103 | 0.000068 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 9 | 9 | AY.20 | 0.00035 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 8 | 8 | AY.23 | 0.000558 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 8 | 8 | AY.54 | 0.000763 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 7 | 7 | AY.42 | 0.000282 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 7 | 7 | B.1 | 0.000064 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 6 | 6 | B.1.177.44 | 0.003114 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 6 | 6 | B.1.221 | 0.000426 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | AY.102 | 0.000133 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | AY.25 | 0.00003 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | AY.9 | 0.000338 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | AY.9.1 | 0.000419 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | B.1.427 | 0.000252 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 5 | 5 | P.1.15 | 0.001162 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 4 | 0.111111 | |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 4 | 4 | AY.5 | 0.000083 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 4 | 4 | B.1.396 | 0.002823 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | AY.26 | 0.000085 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | AY.45 | 0.000365 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | AY.75 | 0.000168 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | AY.99.2 | 0.000276 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.1 | 0.000054 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.258 | 0.0002 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.346 | 0.003932 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.351 | 0.000089 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.526 | 0.000071 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 3 | 3 | B.1.567 | 0.01 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 2 | AY.100 | 0.000092 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 2 | AY.113 | 0.000285 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 2 | AY.46.4 | 0.000329 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 2 | B.1.1.214 | 0.000111 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 2 | 2 | B.1.177 | 0.000026 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.105 | 0.000643 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.114 | 0.000231 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.116 | 0.000287 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.117 | 0.000085 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.16.1 | 0.00047 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.3.1 | 0.000085 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.39 | 0.000025 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.50 | 0.000799 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.6 | 0.000041 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.61 | 0.000105 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.62 | 0.000436 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.75.1 | 0.00018 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.1.1 | 0.000327 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.1.420 | 0.001006 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.1.486 | 0.001577 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.1.8 | 0.003584 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.128 | 0.000635 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.160.31 | 0.008065 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.177.16 | 0.000664 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.177.30 | 0.002513 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.177.57 | 0.000281 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.177.72 | 0.00339 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.234 | 0.000132 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.248 | 0.029412 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.426 | 0.001009 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | B.1.561 | 0.000397 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | C.36 | 0.000911 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | P.1 | 0.000016 |
| ORF1ab/nsp2 | 218 | R218H | cGt | cAt | 1 | 1 | P.2 | 0.000187 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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