CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : Mut = S33K

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp16	33	S33K	S6831K	nonsyn	aGT	aAA	26	26	1	20755-20757

Details of the mutation S33K within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp16	33	S33K	aGT	aAA	26	26	All	0.000005
ORF1ab/nsp16	33	S33K	aGT	aAA	19	19	B.1.429	0.000447
ORF1ab/nsp16	33	S33K	aGT	aAA	4	4	B.1.1.7	0.000004
ORF1ab/nsp16	33	S33K	aGT	aAA	1	1		0.055556
ORF1ab/nsp16	33	S33K	aGT	aAA	1	1	AY.113	0.000142
ORF1ab/nsp16	33	S33K	aGT	aAA	1	1	B.1.427	0.00005

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.