CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : Mut = Q28K
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp16 | 28 | Q28K | Q6826K | nonsyn | Caa | Aaa | 1025 | 1024 | 0.999024 | 20740-20742 |
| ORF1ab/nsp16 | 28 | Q28K | Q6826K | nonsyn | CaA | AaG | 1025 | 1 | 0.00097561 | 20740-20742 |
Details of the mutation Q28K within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1024 | 1025 | All | 0.000196 |
| ORF1ab/nsp16 | 28 | Q28K | CaA | AaG | 1 | 1025 | All | 0 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 111 | 111 | AY.4 | 0.000173 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 100 | 100 | B.1.190 | 1 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 93 | 93 | B.1.617.2 | 0.00035 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 69 | 69 | AY.119 | 0.002436 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 58 | 58 | B.1.177 | 0.000764 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 56 | 56 | AY.44 | 0.000341 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 54 | 55 | B.1.1.7 | 0.000048 |
| ORF1ab/nsp16 | 28 | Q28K | CaA | AaG | 1 | 55 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 54 | 54 | AY.98.1 | 0.002615 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 49 | 49 | AY.43 | 0.000217 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 28 | 28 | B.1.427 | 0.001414 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 24 | 24 | AY.29 | 0.000379 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 24 | 24 | AY.3 | 0.000239 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 24 | 24 | B.1.240 | 0.005174 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 21 | 21 | AY.61 | 0.0022 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 18 | 18 | AY.103 | 0.000112 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 17 | 17 | AY.25 | 0.000102 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 17 | 17 | B.1.177.42 | 0.015206 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 14 | 14 | AY.5 | 0.000289 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 13 | 13 | B.1 | 0.000119 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 11 | 11 | AY.75 | 0.000616 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 10 | 10 | B.1.1 | 0.000181 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 8 | 8 | B.1.2 | 0.00007 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 7 | 7 | B.1.280 | 0.05 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 7 | 7 | P.1 | 0.00011 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 6 | 6 | AY.4.2 | 0.00013 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 6 | 6 | P.1.12 | 0.002904 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 5 | 5 | AY.12 | 0.00158 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 4 | 4 | AY.116 | 0.001147 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 4 | 4 | AY.6 | 0.000165 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 4 | 4 | AY.75.1 | 0.000721 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 4 | 4 | B.1.1.318 | 0.001207 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.120 | 0.000112 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.16.1 | 0.00141 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.47 | 0.000093 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.55 | 0.002752 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.58 | 0.002722 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.9.1 | 0.000251 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | AY.99.2 | 0.000276 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 3 | 3 | B.1.617.1 | 0.000387 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | A.2.5 | 0.000998 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.102 | 0.000053 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.121 | 0.000271 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.13 | 0.000322 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.23 | 0.000139 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.46 | 0.000208 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | AY.86 | 0.00166 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.177.74 | 0.030303 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.214.1 | 0.04 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.243 | 0.000139 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.258 | 0.000133 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.320 | 0.002491 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.351 | 0.000059 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | B.1.36.29 | 0.001035 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 2 | 2 | P.1.9 | 0.009615 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | 0.055556 | |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | A | 0.000387 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | A.2.5.3 | 0.010309 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.113 | 0.000142 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.14 | 0.000088 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.24 | 0.000431 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.33 | 0.000067 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.4.4 | 0.000409 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.45 | 0.000122 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.46.4 | 0.000165 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.5.3 | 0.000337 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.51 | 0.000909 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.59 | 0.00053 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.67 | 0.000464 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.68 | 0.000274 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.72 | 0.001361 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.81 | 0.001992 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.9.2 | 0.000037 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.214 | 0.000055 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.279 | 0.001121 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.284 | 0.000107 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.416 | 0.000905 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.517 | 0.006803 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.177.11 | 0.001698 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.177.65 | 0.000665 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.177.75 | 0.001041 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.177.86 | 0.000183 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.232 | 0.000537 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.270 | 0.005618 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.306 | 0.005714 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.36.18 | 0.00042 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.369 | 0.000285 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.371 | 0.001122 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | B.1.609 | 0.000479 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | C.36.3 | 0.000567 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | P.7 | 0.004367 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | Q.8 | 0.000165 |
| ORF1ab/nsp16 | 28 | Q28K | Caa | Aaa | 1 | 1 | Z.1 | 0.00289 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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