CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : Mut = I237I
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp16 | 237 | I237I | I7035I | syn | atT | atA | 3332 | 1777 | 0.533313 | 21367-21369 |
| ORF1ab/nsp16 | 237 | I237I | I7035I | syn | atT | atC | 3332 | 1555 | 0.466687 | 21367-21369 |
Details of the mutation I237I within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1777 | 3332 | All | 0.00034 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1555 | 3332 | All | 0.000297 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1029 | 1029 | AY.23 | 0.071772 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 927 | 927 | B.1.1.333 | 0.997847 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 785 | 829 | B.1.1.7 | 0.000703 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 44 | 829 | B.1.1.7 | 0.000039 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 108 | 109 | D.2 | 0.008104 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 109 | D.2 | 0.000075 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 59 | 59 | B.1.222 | 0.099831 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 55 | 57 | AY.103 | 0.000341 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 2 | 57 | AY.103 | 0.000012 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 34 | 35 | AY.4 | 0.000053 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 35 | AY.4 | 0.000002 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 19 | 29 | P.1.14 | 0.000908 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 10 | 29 | P.1.14 | 0.000478 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 24 | 24 | AY.3 | 0.000239 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 23 | 24 | Q.8 | 0.003793 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 24 | Q.8 | 0.000165 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 20 | 21 | AY.43 | 0.000089 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 21 | AY.43 | 0.000004 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 17 | 18 | B.1.617.2 | 0.000064 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 18 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 15 | 15 | B.1.621.1 | 0.007587 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 12 | 13 | AY.25 | 0.000072 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 13 | AY.25 | 0.000006 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 10 | 10 | AY.116 | 0.002868 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 10 | 10 | AY.24 | 0.00431 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 8 | 10 | B.1.1 | 0.000145 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 10 | B.1.1 | 0.000036 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 8 | 10 | P.1 | 0.000126 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 2 | 10 | P.1 | 0.000032 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 7 | 7 | AY.44 | 0.000043 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 7 | 7 | B.1 | 0.000064 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 4 | 6 | B.1.2 | 0.000035 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 2 | 6 | B.1.2 | 0.000018 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 5 | 5 | AY.106 | 0.001674 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 4 | 4 | AY.4.2 | 0.000087 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 3 | 3 | AY.20 | 0.000117 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 3 | 3 | AY.33 | 0.0002 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 3 | 3 | B.1.177 | 0.00004 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.113 | 0.000285 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.119 | 0.000071 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 2 | AY.39 | 0.000025 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 2 | AY.39 | 0.000025 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.4.3 | 0.001684 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.45 | 0.000243 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.5.4 | 0.000553 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.69 | 0.000373 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.9.2 | 0.000073 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | AY.92 | 0.000575 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | B.1.1.39 | 0.001019 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | B.1.1.70 | 0.000682 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | B.1.411 | 0.007407 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 2 | P.1.15 | 0.000232 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 2 | P.1.15 | 0.000232 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 2 | 2 | P.1.2 | 0.002312 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 2 | 2 | P.2 | 0.000373 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | AP.1 | 0.001502 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.13 | 0.000161 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.21 | 0.001898 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.32 | 0.000532 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.34.1 | 0.00051 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | AY.36 | 0.000148 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.46 | 0.000104 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.73 | 0.000665 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | AY.80 | 0.001129 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.1.220 | 0.001859 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.1.241 | 0.00207 |
| ORF1ab/nsp16 | 237 | I237I | atT | atA | 1 | 1 | B.1.1.28 | 0.000311 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.1.31 | 0.066667 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.1.411 | 0.014706 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.177.48 | 0.003125 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.221.3 | 0.000833 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.329 | 0.000608 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.36 | 0.000146 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.400 | 0.000429 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.521 | 0.004975 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | C.37 | 0.000116 |
| ORF1ab/nsp16 | 237 | I237I | atT | atC | 1 | 1 | P.1.12 | 0.000484 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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