CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : Mut = H225P

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp16	225	H225P	H7023P	nonsyn	cAt	cCt	9	7	0.777778	21331-21333
ORF1ab/nsp16	225	H225P	H7023P	nonsyn	cAT	cCG	9	1	0.111111	21331-21333
ORF1ab/nsp16	225	H225P	H7023P	nonsyn	cAT	cCA	9	1	0.111111	21331-21333

Details of the mutation H225P within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp16	225	H225P	cAt	cCt	7	9	All	0.000001
ORF1ab/nsp16	225	H225P	cAT	cCG	1	9	All	0
ORF1ab/nsp16	225	H225P	cAT	cCA	1	9	All	0
ORF1ab/nsp16	225	H225P	cAt	cCt	1	2	B.1	0.000009
ORF1ab/nsp16	225	H225P	cAT	cCA	1	2	B.1	0.000009
ORF1ab/nsp16	225	H225P	cAt	cCt	2	2	B.1.235	0.005038
ORF1ab/nsp16	225	H225P	cAT	cCG	1	1	AY.43	0.000004
ORF1ab/nsp16	225	H225P	cAt	cCt	1	1	B.1.1	0.000018
ORF1ab/nsp16	225	H225P	cAt	cCt	1	1	B.1.1.7	0.000001
ORF1ab/nsp16	225	H225P	cAt	cCt	1	1	B.1.596	0.000087
ORF1ab/nsp16	225	H225P	cAt	cCt	1	1	C.37	0.000116

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.