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CoV-GLUE | Mutations | Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : Mut = A226S

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORFCodonNumMutORF1abMutMutTypeRefCodonMutCodonAACountCodonCountCodonPropGenome Position
ORF1ab/nsp16226A226SA7024SnonsynGcaTca125712540.99761321334-21336
ORF1ab/nsp16226A226SA7024SnonsynGcATcC125730.0023866321334-21336

Details of the mutation A226S within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORFCodonNumMutRefCodonMutCodonCodonCountAACountLineageLineageCodonProp
ORF1ab/nsp16226A226SGcaTca12541257All0.00024
ORF1ab/nsp16226A226SGcATcC31257All0.000001
ORF1ab/nsp16226A226SGcaTca300300B.1.617.20.00113
ORF1ab/nsp16226A226SGcaTca192192B.1.2180.989691
ORF1ab/nsp16226A226SGcaTca134134AY.430.000594
ORF1ab/nsp16226A226SGcaTca8282B.1.177.70.013518
ORF1ab/nsp16226A226SGcaTca4646C.360.041894
ORF1ab/nsp16226A226SGcaTca4242AY.270.002718
ORF1ab/nsp16226A226SGcaTca4242AY.440.000256
ORF1ab/nsp16226A226SGcaTca3838AY.40.000059
ORF1ab/nsp16226A226SGcaTca3838B.1.1.5190.001509
ORF1ab/nsp16226A226SGcaTca3737AY.30.000368
ORF1ab/nsp16226A226SGcaTca2525AY.1030.000155
ORF1ab/nsp16226A226SGcaTca2222B.1.1.70.00002
ORF1ab/nsp16226A226SGcaTca1819B.10.000165
ORF1ab/nsp16226A226SGcATcC119B.10.000009
ORF1ab/nsp16226A226SGcaTca1515AY.260.000425
ORF1ab/nsp16226A226SGcaTca1515AY.390.000371
ORF1ab/nsp16226A226SGcaTca1414B.1.10.000254
ORF1ab/nsp16226A226SGcaTca1313AY.1170.001099
ORF1ab/nsp16226A226SGcaTca1313AY.370.004109
ORF1ab/nsp16226A226SGcaTca1111P.10.000173
ORF1ab/nsp16226A226SGcaTca1010AY.50.000206
ORF1ab/nsp16226A226SGcaTca88AY.1020.000212
ORF1ab/nsp16226A226SGcaTca88AY.250.000048
ORF1ab/nsp16226A226SGcaTca55AY.1190.000177
ORF1ab/nsp16226A226SGcaTca55AY.5.40.001384
ORF1ab/nsp16226A226SGcaTca55B.1.1770.000066
ORF1ab/nsp16226A226SGcaTca55B.1.20.000044
ORF1ab/nsp16226A226SGcaTca55B.1.2430.000348
ORF1ab/nsp16226A226SGcaTca44AY.60.000165
ORF1ab/nsp16226A226SGcaTca44AY.840.00175
ORF1ab/nsp16226A226SGcaTca44AY.90.00027
ORF1ab/nsp16226A226SGcaTca44B.1.360.000584
ORF1ab/nsp16226A226SGcaTca44B.1.5250.000453
ORF1ab/nsp16226A226SGcaTca33AY.10.001187
ORF1ab/nsp16226A226SGcaTca33AY.1080.003308
ORF1ab/nsp16226A226SGcaTca33AY.1160.00086
ORF1ab/nsp16226A226SGcaTca33AY.330.0002
ORF1ab/nsp16226A226SGcaTca33AY.460.000312
ORF1ab/nsp16226A226SGcaTca33B.1.1.3020.006224
ORF1ab/nsp16226A226SGcaTca23B.1.2210.000142
ORF1ab/nsp16226A226SGcATcC13B.1.2210.000071
ORF1ab/nsp16226A226SGcaTca33B.1.3980.008929
ORF1ab/nsp16226A226SGcaTca33B.1.617.10.000387
ORF1ab/nsp16226A226SGcaTca22AY.1000.000092
ORF1ab/nsp16226A226SGcaTca22AY.1130.000285
ORF1ab/nsp16226A226SGcaTca22AY.120.000632
ORF1ab/nsp16226A226SGcaTca22AY.46.50.000397
ORF1ab/nsp16226A226SGcaTca22AY.46.60.000144
ORF1ab/nsp16226A226SGcaTca22AY.470.000062
ORF1ab/nsp16226A226SGcaTca22AY.480.00093
ORF1ab/nsp16226A226SGcaTca22AY.98.10.000097
ORF1ab/nsp16226A226SGcaTca22AY.99.20.000184
ORF1ab/nsp16226A226SGcaTca22B.1.1.2200.003717
ORF1ab/nsp16226A226SGcATcC12B.1.1.4110.014706
ORF1ab/nsp16226A226SGcaTca12B.1.1.4110.014706
ORF1ab/nsp16226A226SGcaTca22B.1.6020.013072
ORF1ab/nsp16226A226SGcaTca22D.20.00015
ORF1ab/nsp16226A226SGcaTca11A0.000387
ORF1ab/nsp16226A226SGcaTca11A.20.000662
ORF1ab/nsp16226A226SGcaTca11AD.20.000219
ORF1ab/nsp16226A226SGcaTca11AY.1050.000643
ORF1ab/nsp16226A226SGcaTca11AY.1060.000335
ORF1ab/nsp16226A226SGcaTca11AY.1200.000037
ORF1ab/nsp16226A226SGcaTca11AY.200.000039
ORF1ab/nsp16226A226SGcaTca11AY.3.10.000085
ORF1ab/nsp16226A226SGcaTca11AY.360.000148
ORF1ab/nsp16226A226SGcaTca11AY.46.10.001027
ORF1ab/nsp16226A226SGcaTca11AY.550.000917
ORF1ab/nsp16226A226SGcaTca11AY.610.000105
ORF1ab/nsp16226A226SGcaTca11AY.690.000187
ORF1ab/nsp16226A226SGcaTca11AY.750.000056
ORF1ab/nsp16226A226SGcaTca11AY.890.004902
ORF1ab/nsp16226A226SGcaTca11AY.9.20.000037
ORF1ab/nsp16226A226SGcaTca11AY.980.000079
ORF1ab/nsp16226A226SGcaTca11B0.000128
ORF1ab/nsp16226A226SGcaTca11B.1.1.2220.000204
ORF1ab/nsp16226A226SGcaTca11B.1.1.3290.003846
ORF1ab/nsp16226A226SGcaTca11B.1.1.330.000421
ORF1ab/nsp16226A226SGcaTca11B.1.1.4200.001006
ORF1ab/nsp16226A226SGcaTca11B.1.1110.001175
ORF1ab/nsp16226A226SGcaTca11B.1.1600.000031
ORF1ab/nsp16226A226SGcaTca11B.1.177.200.001517
ORF1ab/nsp16226A226SGcaTca11B.1.177.40.000211
ORF1ab/nsp16226A226SGcaTca11B.1.177.790.002342
ORF1ab/nsp16226A226SGcaTca11B.1.36.240.006173
ORF1ab/nsp16226A226SGcaTca11B.1.4000.000429
ORF1ab/nsp16226A226SGcaTca11B.1.5750.000303
ORF1ab/nsp16226A226SGcaTca11B.1.5990.00365
ORF1ab/nsp16226A226SGcaTca11B.1.6210.000089
ORF1ab/nsp16226A226SGcaTca11B.580.010204
ORF1ab/nsp16226A226SGcaTca11C.2.10.006667
ORF1ab/nsp16226A226SGcaTca11R.10.00009

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

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