CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp16 : CodonNum = 33 & Codon = Cgt

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp16	33	S33R	S6831R	nonsyn	Agt	Cgt	539	511	0.948052	20755-20757

Details of the mutation no within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp16	33	S33R	Agt	Cgt	511	539	All	0.000098
ORF1ab/nsp16	33	S33R	Agt	Cgt	370	370	B.1	0.003389
ORF1ab/nsp16	33	S33R	Agt	Cgt	77	77	B.1.445	0.905882
ORF1ab/nsp16	33	S33R	Agt	Cgt	29	29	B.1.308	1
ORF1ab/nsp16	33	S33R	Agt	Cgt	20	20	B.1.310	0.952381
ORF1ab/nsp16	33	S33R	Agt	Cgt	5	5	B.1.1.519	0.000199
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	2	B.1.177	0.000013
ORF1ab/nsp16	33	S33R	Agt	Cgt	2	2	B.1.453	0.006472
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	A	0.000387
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.1.1	0.000327
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.293	0.0125
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.324	0.001605
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.390	0.010638
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.443	0.004673
ORF1ab/nsp16	33	S33R	Agt	Cgt	1	1	B.1.626	0.005714

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.