CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = V313V
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 313 | V313V | V6765V | syn | gtA | gtG | 356 | 320 | 0.898876 | 20557-20559 |
| ORF1ab/nsp15A1-B | 313 | V313V | V6765V | syn | gtA | gtT | 356 | 19 | 0.0533708 | 20557-20559 |
| ORF1ab/nsp15A1-B | 313 | V313V | V6765V | syn | gtA | gtC | 356 | 17 | 0.0477528 | 20557-20559 |
Details of the mutation V313V within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 320 | 356 | All | 0.000061 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 19 | 356 | All | 0.000004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 17 | 356 | All | 0.000003 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 59 | 60 | AY.4 | 0.000092 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 60 | AY.4 | 0.000002 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 57 | 57 | B.1.36.23 | 0.934426 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 35 | 36 | AY.43 | 0.000155 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 36 | AY.43 | 0.000004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 17 | 31 | B.1.1.7 | 0.000015 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 9 | 31 | B.1.1.7 | 0.000008 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 5 | 31 | B.1.1.7 | 0.000004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 18 | 18 | B.1.617.2 | 0.000068 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 13 | 13 | AY.87 | 0.010824 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 12 | 12 | AY.3 | 0.000119 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 6 | 10 | P.1 | 0.000095 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 10 | P.1 | 0.000063 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 7 | 7 | AY.44 | 0.000043 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 7 | 7 | B.1.526 | 0.000165 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 6 | 6 | AY.103 | 0.000037 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 5 | 5 | AY.54 | 0.000477 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 3 | 5 | B.1.2 | 0.000026 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 5 | B.1.2 | 0.000018 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | AY.102 | 0.000106 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | AY.120 | 0.000149 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | AY.4.2 | 0.000087 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | B.1 | 0.000037 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | B.1.1.333 | 0.004306 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | B.1.509 | 0.003463 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 4 | 4 | B.1.617.1 | 0.000516 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 3 | 3 | AY.32 | 0.001597 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 3 | 3 | AY.39 | 0.000074 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 3 | 3 | AY.61 | 0.000314 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 3 | B.1.36 | 0.000292 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 3 | B.1.36 | 0.000146 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 3 | 3 | D.2 | 0.000225 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | AY.24 | 0.000862 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 2 | AY.33 | 0.000067 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 2 | AY.33 | 0.000067 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | AY.45 | 0.000243 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | AY.99.2 | 0.000184 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 2 | 2 | B.1.1.26 | 0.010471 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | B.1.1.306 | 0.000877 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 2 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 2 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | B.1.429 | 0.000047 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | B.1.568 | 0.002222 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 2 | 2 | B.1.628 | 0.000705 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 1 | A.2.4 | 0.003367 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.100 | 0.000046 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.2 | 0.000356 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.25 | 0.000006 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.26 | 0.000028 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.29 | 0.000016 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 1 | AY.30 | 0.000396 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.39.1 | 0.00004 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 1 | AY.48 | 0.000465 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | AY.98 | 0.000079 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.160 | 0.000031 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 1 | B.1.177.4 | 0.000211 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.240 | 0.000216 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.320 | 0.001245 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.351 | 0.00003 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.36.39 | 0.002217 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtT | 1 | 1 | B.1.462 | 0.007246 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtC | 1 | 1 | B.1.497 | 0.000315 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.525 | 0.000113 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.582 | 0.000491 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | B.1.596 | 0.000087 |
| ORF1ab/nsp15A1-B | 313 | V313V | gtA | gtG | 1 | 1 | R.1 | 0.00009 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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