CoV-GLUE Mutation

CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = T114M

Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):

ORF	CodonNum	Mut	ORF1abMut	MutType	RefCodon	MutCodon	AACount	CodonCount	CodonProp	Genome Position
ORF1ab/nsp15A1-B	114	T114M	T6566M	nonsyn	aCg	aTg	4203	4203	1	19960-19962

Details of the mutation T114M within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):

ORF	CodonNum	Mut	RefCodon	MutCodon	CodonCount	AACount	Lineage	LineageCodonProp
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4203	4203	All	0.000804
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1171	1171	B.1.1.7	0.001048
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	480	480	B.1.617.2	0.001807
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	276	276	AY.4	0.00043
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	257	257	AY.43	0.001139
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	125	125	B.1.243	0.008698
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	113	113	AY.9.1	0.009461
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	88	88	B.1.177.86	0.016144
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	73	73	AY.44	0.000444
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	67	67	AY.42	0.002695
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	65	65	B.1.561	0.025804
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	64	64	B.1.160	0.001996
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	64	64	B.1.628	0.022551
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	61	61	B.1.2	0.000537
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	49	49	AD.2	0.010729
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	47	47	B.1.177	0.000619
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	45	45	AY.103	0.000279
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	45	45	AY.3	0.000448
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	45	45	B.1	0.000412
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	43	43	AY.33	0.002871
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	41	41	AY.25	0.000247
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	40	40	B.1.429	0.000941
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	40	40	P.2	0.007465
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	37	37	AY.20	0.001438
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	34	34	AY.4.2	0.000737
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	30	30	P.1	0.000473
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	28	28	AY.61	0.002934
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	28	28	B.1.1	0.000508
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	27	27	B.1.1.214	0.001497
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	27	27	B.1.36.18	0.011345
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	26	26	AY.119	0.000918
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	22	22	B.1.526	0.000517
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	21	21	AY.29	0.000331
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	21	21	B.1.221	0.001492
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	20	20	B.1.427	0.00101
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	18	18	B.1.1.145	0.666667
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	17	17	AY.26	0.000481
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	16	16	AY.39	0.000395
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	15	15	B.1.637	0.001096
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	15	15	Q.8	0.002474
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	14	14	B.1.258.14	0.013725
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	14	14	B.1.438.1	0.001502
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	13	13	AY.46	0.001353
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	13	13	B.1.258	0.000865
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	13	13	P.1.7	0.004151
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	12	12	B.1.1.519	0.000477
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	11	11	AY.102	0.000292
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	9	9	A.2.5	0.004491
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	9	9	AY.27	0.000582
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.100	0.000368
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.120	0.000297
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.45	0.000973
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.46.6	0.000578
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.70	0.001668
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	AY.98	0.000632
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	B.1.1.116	0.5
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	8	8	B.1.1.284	0.000859
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	7	7	B.1.396	0.00494
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	7	7	C.37	0.000812
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	7	7	Q.3	0.001015
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	6	6	AY.23.1	0.002504
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	6	6	AY.4.5	0.000645
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	6	6	AY.47	0.000187
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	6	6	B.1.351	0.000178
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	6	6	P.1.17	0.000971
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.117	0.000423
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.16.1	0.00235
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.64	0.002976
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.75	0.00028
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.9	0.000338
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	AY.99.2	0.000461
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	B.1.177.60	0.001092
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	B.1.210	0.010661
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	B.1.596	0.000436
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	5	5	P.1.14	0.000239
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	AY.111	0.000733
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	AY.118	0.000251
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	AY.5	0.000083
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	AY.52	0.003257
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	AY.9.2	0.000147
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.1.516	0.266667
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.236	0.008214
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.241	0.003247
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.258.17	0.000416
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.36.29	0.002069
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.595	0.001044
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	4	4	B.1.602	0.026144
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.107	0.001398
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.12	0.000948
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.121	0.000406
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.3.1	0.000256
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.37	0.000948
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.46.1	0.00308
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.58	0.002722
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.75.1	0.000541
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	AY.91	0.002191
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	B.1.1.315	0.025424
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	B.1.1.70	0.001023
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	B.1.177.7	0.000495
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	B.1.564	0.001278
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	B.1.9.5	0.017045
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	3	3	Z.1	0.008671
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.101	0.000981
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.106	0.00067
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.113	0.000285
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.13	0.000322
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.16	0.000759
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.36	0.000296
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.39.1	0.000079
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.4.4	0.000818
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.41	0.000588
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.46.2	0.001271
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.55	0.001835
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.60	0.001876
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.62	0.000871
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.67	0.000929
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.68	0.000547
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.7.1	0.000225
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	AY.93	0.000546
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.1.1	0.000653
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.1.28	0.000622
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.177.12	0.000303
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.177.19	0.002861
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.177.57	0.000562
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.221.3	0.001667
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.311	0.000549
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.369	0.00057
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.408	0.00738
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.469	0.00722
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.568	0.002222
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	B.1.621	0.000177
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	D.2	0.00015
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	P.1.12	0.000968
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	P.1.15	0.000465
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	2	2	R.1	0.00018
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	A.1	0.000282
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	A.2.5.2	0.001572
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AA.7	0.009174
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.104	0.001984
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.110	0.000113
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.116	0.000287
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.14	0.000088
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.2	0.000356
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.23	0.00007
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.40	0.000964
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.49	0.003195
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.54	0.000095
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.59	0.00053
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.65	0.000533
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.89	0.004902
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AY.98.1	0.000048
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	AZ.3	0.00152
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B	0.000128
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.101	0.01
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.129	0.009174
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.191	0.004762
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.205	0.003717
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.241	0.00207
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.25	0.000569
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.263	0.001558
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.316	0.000925
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.348	0.000796
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.376	0.005952
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.383	0.0625
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.39	0.00051
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.434	0.000349
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.44	0.00241
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.464	0.001473
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.1.50	0.000679
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.111	0.001175
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.115	0.021739
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.140	0.018868
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.160.29	0.004219
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.21	0.000076
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.42	0.000894
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.46	0.000918
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.65	0.000665
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.73	0.000566
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.177.79	0.002342
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.258.7	0.001912
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.265	0.001271
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.309	0.047619
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.319	0.003049
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.35	0.008475
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.36	0.000146
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.399	0.001934
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.411	0.003704
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.498	0.020408
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.502	0.052632
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.537	0.02
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.591	0.010638
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.1.609	0.000479
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.20	0.023256
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.4	0.002208
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.40	0.000364
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.47	0.020408
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.6	0.00091
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.6.6	0.000889
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	B.60	0.015873
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	C.36.3	0.000567
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	D.3	0.005917
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	N.4	0.004255
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	N.5	0.001767
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	P.1.16	0.000374
ORF1ab/nsp15A1-B	114	T114M	aCg	aTg	1	1	Q.1	0.000126

CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk

CoV-GLUE uses sequence data from GISAID. GISAID data provided via this web application is subject to GISAID's Terms and Conditions.