CoV-GLUE | Mutations | Mutation
CoV-GLUE Mutation: ORF = ORF1ab/nsp15A1-B : Mut = T105T
Details of the codons used for the mutation across all lineages (CodonProp is the proportion each codon is used for this AA mutation):
| ORF | CodonNum | Mut | ORF1abMut | MutType | RefCodon | MutCodon | AACount | CodonCount | CodonProp | Genome Position |
| ORF1ab/nsp15A1-B | 105 | T105T | T6557T | syn | acT | acC | 666 | 392 | 0.588589 | 19933-19935 |
| ORF1ab/nsp15A1-B | 105 | T105T | T6557T | syn | acT | acA | 666 | 249 | 0.373874 | 19933-19935 |
| ORF1ab/nsp15A1-B | 105 | T105T | T6557T | syn | acT | acG | 666 | 25 | 0.0375375 | 19933-19935 |
Details of the mutation T105T within lineages (LineageCodonProp is the proportion the codon is observed at, at this particular site, on each lineage):
| ORF | CodonNum | Mut | RefCodon | MutCodon | CodonCount | AACount | Lineage | LineageCodonProp |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 392 | 666 | All | 0.000075 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 249 | 666 | All | 0.000048 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 25 | 666 | All | 0.000005 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 156 | 212 | B.1.1.7 | 0.00014 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 55 | 212 | B.1.1.7 | 0.000049 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 212 | B.1.1.7 | 0.000001 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 65 | 65 | AY.103 | 0.000404 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 56 | 59 | B.1.2 | 0.000493 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 3 | 59 | B.1.2 | 0.000026 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 29 | 41 | B.1.617.2 | 0.000109 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 11 | 41 | B.1.617.2 | 0.000041 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 41 | B.1.617.2 | 0.000004 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 32 | 37 | AY.4 | 0.00005 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 3 | 37 | AY.4 | 0.000005 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 2 | 37 | AY.4 | 0.000003 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 13 | 25 | AY.43 | 0.000058 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 9 | 25 | AY.43 | 0.00004 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 3 | 25 | AY.43 | 0.000013 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 13 | 16 | AY.3 | 0.000129 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 3 | 16 | AY.3 | 0.00003 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 11 | 15 | AY.102 | 0.000292 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 4 | 15 | AY.102 | 0.000106 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 15 | 15 | AY.46 | 0.001561 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 13 | 13 | M.3 | 1 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 9 | 11 | AY.44 | 0.000055 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 2 | 11 | AY.44 | 0.000012 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 8 | 8 | B.1.1.318 | 0.002414 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 7 | 7 | AY.75 | 0.000392 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 6 | 7 | B.1 | 0.000055 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 7 | B.1 | 0.000009 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 7 | 7 | B.1.258.14 | 0.006863 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 6 | 6 | AY.25 | 0.000036 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 6 | 6 | AY.46.4 | 0.000987 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 6 | 6 | M.2 | 0.5 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 5 | 5 | AY.100 | 0.00023 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 5 | B.1.177 | 0.000026 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 2 | 5 | B.1.177 | 0.000026 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 5 | B.1.177 | 0.000013 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 4 | 5 | B.1.351 | 0.000119 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 5 | B.1.351 | 0.00003 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 4 | 5 | C.37 | 0.000464 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 5 | C.37 | 0.000116 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 4 | 4 | AY.117 | 0.000338 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 4 | 4 | AY.33 | 0.000267 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 3 | 4 | AY.39 | 0.000074 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 4 | AY.39 | 0.000025 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 3 | 3 | AY.108 | 0.003308 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 3 | 3 | AY.42 | 0.000121 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 3 | B.1.1 | 0.000036 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 3 | B.1.1 | 0.000018 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 3 | 3 | B.1.234 | 0.000396 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 3 | 3 | B.1.427 | 0.000151 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 2 | 3 | B.1.429 | 0.000047 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 3 | B.1.429 | 0.000024 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 3 | 3 | B.1.525 | 0.000339 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 3 | B.1.596 | 0.000174 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 3 | B.1.596 | 0.000087 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 2 | AY.119 | 0.000035 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 2 | AY.119 | 0.000035 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 2 | AY.120 | 0.000074 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 2 | 2 | AY.20 | 0.000078 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 2 | 2 | AY.4.2 | 0.000043 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 2 | AY.61 | 0.00021 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 2 | AY.9.2 | 0.000037 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 2 | AY.9.2 | 0.000037 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 2 | AY.98 | 0.000158 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 2 | B.1.243 | 0.00007 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 2 | B.1.243 | 0.00007 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 2 | 2 | P.1 | 0.000032 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.2 | 0.000356 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.23 | 0.00007 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | AY.27 | 0.000065 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.34 | 0.000097 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.4.5 | 0.000107 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | AY.46.6 | 0.000072 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | AY.5 | 0.000021 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | AY.65 | 0.000533 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.70 | 0.000209 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.71 | 0.000475 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.74 | 0.000116 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | AY.84 | 0.000437 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.93 | 0.000273 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | AY.98.1 | 0.000048 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B | 0.000128 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.1.306 | 0.000438 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.1.397 | 0.002252 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.1.50 | 0.000679 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | B.1.1.519 | 0.00004 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.177.16 | 0.000664 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.177.65 | 0.000665 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | B.1.258 | 0.000067 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.258.17 | 0.000104 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | B.1.311 | 0.000275 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | B.1.36.22 | 0.001208 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | B.1.466.2 | 0.000391 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.526 | 0.000024 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acA | 1 | 1 | B.1.595 | 0.000261 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acG | 1 | 1 | B.1.617.1 | 0.000129 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.621 | 0.000089 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | B.1.637 | 0.000073 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | C.16 | 0.00106 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | D.2 | 0.000075 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | P.1.14 | 0.000048 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | P.1.16 | 0.000374 |
| ORF1ab/nsp15A1-B | 105 | T105T | acT | acC | 1 | 1 | P.1.7 | 0.000319 |
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CoV-GLUE is still in development. CoV-GLUE was originally developed as part of COG-UK by Josh Singer using the GLUE framework at the MRC-University of Glasgow Centre for Virus Research (CVR). In 2021 it was redeveloped by Richard Orton to scale to the millions of genome sequences available. We acknowledge support from the MRC (MC_UU_12014/12), WT (220977/Z/20/Z) and UKRI G2P (MR/W005611/1). Please contact Richard Orton with any queries: Richard.Orton@glasgow.ac.uk
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